UBE2V2 and SHPRH

Number of citations of the paper that reports this interaction (PubMedID 17108083)
33

Data Source:
BioGRID (pull down)

		UBE2V2	SHPRH
Description		ubiquitin conjugating enzyme E2 V2	SNF2 histone linker PHD RING helicase
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Ubiquitin Conjugating Enzyme Complex UBC13-MMS2 Complex Extracellular Exosome	Nucleosome Nucleus Nucleoplasm
	Molecular Function	Protein Binding	Nucleotide Binding DNA Binding Helicase Activity Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Zinc Ion Binding Transferase Activity Hydrolase Activity Ubiquitin Protein Ligase Binding Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Protein Polyubiquitination DNA Double-strand Break Processing Regulation Of DNA Repair Postreplication Repair Protein Ubiquitination Error-free Postreplication DNA Repair Protein K63-linked Ubiquitination Positive Regulation Of Protein K63-linked Ubiquitination Positive Regulation Of Double-strand Break Repair	Protein Polyubiquitination DNA Repair Nucleosome Assembly DNA Damage Response Protein Ubiquitination
Pathways		Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Nonhomologous End-Joining (NHEJ) Processing of DNA double-strand break ends Formation of Incision Complex in GG-NER G2/M DNA damage checkpoint E3 ubiquitin ligases ubiquitinate target proteins Antigen processing: Ubiquitination & Proteasome degradation	E3 ubiquitin ligases ubiquitinate target proteins
Drugs
Diseases
GWAS		Height ( 31562340)
Interacting Genes		32 interacting genes: BCL10 DZIP3 EGFR HLTF IGSF21 LRIF1 MALT1 MKRN3 MOB4 MUL1 RC3H1 RC3H2 RFFL RNF111 RNF144A RNF2 RNF8 SHPRH SIAH1 SIAH2 STUB1 SUV39H2 TP53 TRAF2 TRIM5 TRIM54 TRIM63 UBC UBE2N UBE3B XIAP ZNRF1	12 interacting genes: BORCS6 EDARADD FBXW7 FDFT1 H3C1 H4C1 LPP RAD18 UBE2D1 UBE2N UBE2V2 YWHAG
Entrez ID		7336	257218
HPRD ID		04300	10476
Ensembl ID		ENSG00000169139	ENSG00000146414
Uniprot IDs		A0M8W4 Q15819	B3KX98 Q149N8
PDB IDs		1J74 1J7D 1ZGU 3VON 4NR3 4NRG 4NRI 4ONL 4ONM 4ONN 4ORH 5AIT 7BBD 7BBF 8WR5 9BIV	2M85 4QN1
Enriched GO Terms of Interacting Partners?		Ubiquitin Protein Ligase Activity Protein Ubiquitination Protein Modification By Small Protein Conjugation Ubiquitin-protein Transferase Activity Protein Polyubiquitination Post-translational Protein Modification Transferase Activity Protein Modification Process Zinc Ion Binding Ubiquitin Protein Ligase Binding Proteolysis Involved In Protein Catabolic Process Modification-dependent Protein Catabolic Process Protein Metabolic Process Ubiquitin-dependent Protein Catabolic Process Macromolecule Catabolic Process Proteolysis Metal Ion Binding Positive Regulation Of Post-translational Protein Modification Protein K63-linked Ubiquitination Macromolecule Metabolic Process Catabolic Process Regulation Of Post-translational Protein Modification Positive Regulation Of Protein Modification Process Positive Regulation Of Protein Ubiquitination Ubiquitin Ligase Complex Activation Of Immune Response Regulation Of Protein Ubiquitination Regulation Of Intracellular Signal Transduction Regulation Of Protein Modification Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Immune Response-activating Signaling Pathway Positive Regulation Of Immune Response Positive Regulation Of Signal Transduction Positive Regulation Of Intracellular Signal Transduction Regulation Of Immune Response Immune Response-regulating Signaling Pathway Regulation Of Signal Transduction Positive Regulation Of Cell Communication Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Signaling Regulation Of Canonical NF-kappaB Signal Transduction T Cell Receptor Signaling Pathway Immune System Process Polkadots Immune Response-activating Cell Surface Receptor Signaling Pathway Antigen Receptor-mediated Signaling Pathway Positive Regulation Of Immune System Process T Cell Proliferation Immune Response-regulating Cell Surface Receptor Signaling Pathway	Regulation Of Protein Polyubiquitination Positive Regulation Of Post-translational Protein Modification Positive Regulation Of Protein Polyubiquitination Positive Regulation Of Protein Ubiquitination Protein Ubiquitination Postreplication Repair UBC13-MMS2 Complex Ubiquitin Conjugating Enzyme Complex Protein Modification By Small Protein Conjugation Regulation Of Protein Ubiquitination Post-translational Protein Modification TORC1 Signaling Negative Regulation Of TORC1 Signaling Positive Regulation Of Protein K63-linked Ubiquitination Ubiquitin-protein Transferase Activator Activity Regulation Of Post-translational Protein Modification TOR Signaling Protein Polyubiquitination Negative Regulation Of TOR Signaling Regulation Of TORC1 Signaling Regulation Of Protein K63-linked Ubiquitination Regulation Of Protein Modification Process Positive Regulation Of Protein Modification Process Protein-containing Complex Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process DNA Double-strand Break Processing Positive Regulation Of Protein Metabolic Process Regulation Of TOR Signaling Ubiquitin Conjugating Enzyme Activity Proteasomal Protein Catabolic Process DNA Repair Protein Modification Process Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Squalene Synthase [NAD(P)H] Activity Protein Catabolic Process Cellular Response To Nutrient Levels Protein Monoubiquitination Rad6-Rad18 Complex SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Chromosome Ubiquitin Protein Ligase Binding Protein K63-linked Ubiquitination DNA Metabolic Process Error-free Postreplication DNA Repair Negative Regulation Of Intracellular Signal Transduction Chromosome Organization Structural Constituent Of Chromatin DNA Damage Response
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