UBE2V2 and HLTF

Number of citations of the paper that reports this interaction (PubMedID 22904075)
36

Data Source:
BioGRID (pull down, affinity chromatography technology, affinity chromatography technology, pull down)

		UBE2V2	HLTF
Description		ubiquitin conjugating enzyme E2 V2	helicase like transcription factor
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Ubiquitin Conjugating Enzyme Complex UBC13-MMS2 Complex Extracellular Exosome	Nucleus Nucleoplasm Nucleolus Cytoplasm Plasma Membrane Membrane Nuclear Matrix Nuclear Replication Fork RNA Polymerase II Transcription Regulator Complex
	Molecular Function	Protein Binding	Nucleotide Binding Nucleic Acid Binding DNA Binding Single-stranded DNA Binding RNA Binding Catalytic Activity Helicase Activity Protein Binding ATP Binding ATP-dependent Activity, Acting On DNA Zinc Ion Binding DNA Translocase Activity Transferase Activity Hydrolase Activity Hydrolase Activity, Acting On Acid Anhydrides, In Phosphorus-containing Anhydrides Ubiquitin Protein Ligase Binding Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Protein Polyubiquitination DNA Double-strand Break Processing Regulation Of DNA Repair Postreplication Repair Protein Ubiquitination Error-free Postreplication DNA Repair Protein K63-linked Ubiquitination Positive Regulation Of Protein K63-linked Ubiquitination Positive Regulation Of Double-strand Break Repair	Protein Polyubiquitination DNA Repair Chromatin Organization DNA Damage Response Protein Ubiquitination MRNA Transcription By RNA Polymerase II Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Neurogenesis Replication Fork Reversal
Pathways		Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Nonhomologous End-Joining (NHEJ) Processing of DNA double-strand break ends Formation of Incision Complex in GG-NER G2/M DNA damage checkpoint E3 ubiquitin ligases ubiquitinate target proteins Antigen processing: Ubiquitination & Proteasome degradation	E3 ubiquitin ligases ubiquitinate target proteins
Drugs
Diseases
GWAS		Height ( 31562340)
Interacting Genes		32 interacting genes: BCL10 DZIP3 EGFR HLTF IGSF21 LRIF1 MALT1 MKRN3 MOB4 MUL1 RC3H1 RC3H2 RFFL RNF111 RNF144A RNF2 RNF8 SHPRH SIAH1 SIAH2 STUB1 SUV39H2 TP53 TRAF2 TRIM5 TRIM54 TRIM63 UBC UBE2N UBE3B XIAP ZNRF1	14 interacting genes: CDK9 CEBPA DCAF1 EEF1G EWSR1 HSPA8 SP1 SP3 SULT1C2 UBC UBE2A UBE2V2 UBE2Z WBP4
Entrez ID		7336	6596
HPRD ID		04300	04461
Ensembl ID		ENSG00000169139	ENSG00000071794
Uniprot IDs		A0M8W4 Q15819	A0A0C4DGA6 A8K5B6 Q05BZ6 Q14527
PDB IDs		1J74 1J7D 1ZGU 3VON 4NR3 4NRG 4NRI 4ONL 4ONM 4ONN 4ORH 5AIT 7BBD 7BBF 8WR5 9BIV	2MZN 4HRE 4HRH 4S0N 4XZF 4XZG 5BNH 5K5F 6KCS
Enriched GO Terms of Interacting Partners?		Ubiquitin Protein Ligase Activity Protein Ubiquitination Protein Modification By Small Protein Conjugation Ubiquitin-protein Transferase Activity Protein Polyubiquitination Post-translational Protein Modification Transferase Activity Protein Modification Process Zinc Ion Binding Ubiquitin Protein Ligase Binding Proteolysis Involved In Protein Catabolic Process Modification-dependent Protein Catabolic Process Protein Metabolic Process Ubiquitin-dependent Protein Catabolic Process Macromolecule Catabolic Process Proteolysis Metal Ion Binding Positive Regulation Of Post-translational Protein Modification Protein K63-linked Ubiquitination Macromolecule Metabolic Process Catabolic Process Regulation Of Post-translational Protein Modification Positive Regulation Of Protein Modification Process Positive Regulation Of Protein Ubiquitination Ubiquitin Ligase Complex Activation Of Immune Response Regulation Of Protein Ubiquitination Regulation Of Intracellular Signal Transduction Regulation Of Protein Modification Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Immune Response-activating Signaling Pathway Positive Regulation Of Immune Response Positive Regulation Of Signal Transduction Positive Regulation Of Intracellular Signal Transduction Regulation Of Immune Response Immune Response-regulating Signaling Pathway Regulation Of Signal Transduction Positive Regulation Of Cell Communication Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Signaling Regulation Of Canonical NF-kappaB Signal Transduction T Cell Receptor Signaling Pathway Immune System Process Polkadots Immune Response-activating Cell Surface Receptor Signaling Pathway Antigen Receptor-mediated Signaling Pathway Positive Regulation Of Immune System Process T Cell Proliferation Immune Response-regulating Cell Surface Receptor Signaling Pathway	Nucleoplasm Nucleus Host-mediated Perturbation Of Viral Transcription Host-mediated Activation Of Viral Transcription Granulocyte Differentiation Embryonic Placenta Development Protein Ubiquitination Protein Modification By Small Protein Conjugation Host-mediated Activation Of Viral Process Post-translational Protein Modification Postreplication Repair Ubiquitin Conjugating Enzyme Activity Nucleic Acid Metabolic Process RNA Polymerase II-specific DNA-binding Transcription Factor Binding Protein Metabolic Process RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Chaperone-mediated Autophagy Translocation Complex Disassembly Positive Regulation Of Hydrogen Sulfide Biosynthetic Process Protein-DNA Complex Cellular Response To Wortmannin Histone H2AT120 Kinase Activity Cell Competition In A Multicellular Organism Cellular Response To Stress Macromolecule Metabolic Process Modification-dependent Protein Catabolic Process Macromolecule Catabolic Process Protein Modification Process Transcription Cis-regulatory Region Binding Transcription Repressor Complex P-TEFb Complex Response To Vitamin B2 C/EBP Complex Lumenal Side Of Lysosomal Membrane Response To Wortmannin Cholesterol Sulfotransferase Activity Error-free Postreplication DNA Repair Host-mediated Perturbation Of Viral Process Ubiquitin Protein Ligase Binding Proteolysis Involved In Protein Catabolic Process Nucleobase-containing Compound Metabolic Process Mononuclear Cell Differentiation DNA Metabolic Process Positive Regulation Of Protein Localization To Chromatin CHOP-C/EBP Complex Regulation Of Protein Import UBC13-MMS2 Complex Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process ATP Binding Regulation Of Nucleobase-containing Compound Metabolic Process
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