UBE2V2 and UBE3B

Number of citations of the paper that reports this interaction (PubMedID 37783786)
0

Data Source:
BioGRID (pull down)

		UBE2V2	UBE3B
Description		ubiquitin conjugating enzyme E2 V2	ubiquitin protein ligase E3B
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Ubiquitin Conjugating Enzyme Complex UBC13-MMS2 Complex Extracellular Exosome	Mitochondrion Postsynaptic Density Synapse Postsynapse Glutamatergic Synapse
	Molecular Function	Protein Binding	Ubiquitin-protein Transferase Activity Protein Binding Transferase Activity Ubiquitin Protein Ligase Activity
	Biological Process	Protein Polyubiquitination DNA Double-strand Break Processing Regulation Of DNA Repair Postreplication Repair Protein Ubiquitination Error-free Postreplication DNA Repair Protein K63-linked Ubiquitination Positive Regulation Of Protein K63-linked Ubiquitination Positive Regulation Of Double-strand Break Repair	Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Regulation Of Postsynapse Assembly
Pathways		Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Nonhomologous End-Joining (NHEJ) Processing of DNA double-strand break ends Formation of Incision Complex in GG-NER G2/M DNA damage checkpoint E3 ubiquitin ligases ubiquitinate target proteins Antigen processing: Ubiquitination & Proteasome degradation	Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Height ( 31562340)	Coronary artery disease ( 32469254) Fish- and plant-related diet ( 32066663) HDL cholesterol ( 20864672) HDL cholesterol levels ( 30698716) HDL cholesterol levels in current drinkers ( 30698716) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) High density lipoprotein cholesterol levels ( 33339817) Mean corpuscular hemoglobin ( 32888494) Non-oily fish consumption ( 32066663) Oily fish consumption ( 32066663) Polymyositis ( 26362759) Pork consumption ( 32066663) PR interval ( 32439900) Total cholesterol levels ( 30275531 33339817)
Interacting Genes		32 interacting genes: BCL10 DZIP3 EGFR HLTF IGSF21 LRIF1 MALT1 MKRN3 MOB4 MUL1 RC3H1 RC3H2 RFFL RNF111 RNF144A RNF2 RNF8 SHPRH SIAH1 SIAH2 STUB1 SUV39H2 TP53 TRAF2 TRIM5 TRIM54 TRIM63 UBC UBE2N UBE3B XIAP ZNRF1	8 interacting genes: CDC34 EPAS1 HIF1A HRAS MYC UBE2N UBE2V1 UBE2V2
Entrez ID		7336	89910
HPRD ID		04300	06993
Ensembl ID		ENSG00000169139	ENSG00000151148
Uniprot IDs		A0M8W4 Q15819	Q7Z3V4
PDB IDs		1J74 1J7D 1ZGU 3VON 4NR3 4NRG 4NRI 4ONL 4ONM 4ONN 4ORH 5AIT 7BBD 7BBF 8WR5 9BIV
Enriched GO Terms of Interacting Partners?		Ubiquitin Protein Ligase Activity Protein Ubiquitination Protein Modification By Small Protein Conjugation Ubiquitin-protein Transferase Activity Protein Polyubiquitination Post-translational Protein Modification Transferase Activity Protein Modification Process Zinc Ion Binding Ubiquitin Protein Ligase Binding Proteolysis Involved In Protein Catabolic Process Modification-dependent Protein Catabolic Process Protein Metabolic Process Ubiquitin-dependent Protein Catabolic Process Macromolecule Catabolic Process Proteolysis Metal Ion Binding Positive Regulation Of Post-translational Protein Modification Protein K63-linked Ubiquitination Macromolecule Metabolic Process Catabolic Process Regulation Of Post-translational Protein Modification Positive Regulation Of Protein Modification Process Positive Regulation Of Protein Ubiquitination Ubiquitin Ligase Complex Activation Of Immune Response Regulation Of Protein Ubiquitination Regulation Of Intracellular Signal Transduction Regulation Of Protein Modification Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Immune Response-activating Signaling Pathway Positive Regulation Of Immune Response Positive Regulation Of Signal Transduction Positive Regulation Of Intracellular Signal Transduction Regulation Of Immune Response Immune Response-regulating Signaling Pathway Regulation Of Signal Transduction Positive Regulation Of Cell Communication Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Signaling Regulation Of Canonical NF-kappaB Signal Transduction T Cell Receptor Signaling Pathway Immune System Process Polkadots Immune Response-activating Cell Surface Receptor Signaling Pathway Antigen Receptor-mediated Signaling Pathway Positive Regulation Of Immune System Process T Cell Proliferation Immune Response-regulating Cell Surface Receptor Signaling Pathway	UBC13-MMS2 Complex Ubiquitin Conjugating Enzyme Complex Positive Regulation Of Protein K63-linked Ubiquitination Regulation Of Post-translational Protein Modification Regulation Of Protein K63-linked Ubiquitination Positive Regulation Of Protein Polyubiquitination Error-free Postreplication DNA Repair Regulation Of Protein Polyubiquitination Ubiquitin Conjugating Enzyme Activity Postreplication Repair Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of MiRNA Metabolic Process Regulation Of Protein Modification Process Protein K63-linked Ubiquitination Protein Polyubiquitination Cis-regulatory Region Sequence-specific DNA Binding Nucleoplasm Regulation Of MiRNA Metabolic Process Intracellular Oxygen Homeostasis Positive Regulation Of Protein Ubiquitination Cellular Response To Stress Positive Regulation Of Post-translational Protein Modification Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Regulation Of Protein Neddylation Positive Regulation Of Macromolecule Metabolic Process Cellular Response To Oxygen Levels Response To Stress Regulation Of DNA Metabolic Process Epithelial Cell Maturation DNA Double-strand Break Processing Nucleic Acid Metabolic Process Embryonic Placenta Development Regulation Of Cellular Response To Stress Protein Dimerization Activity Regulation Of Protein Ubiquitination Positive Regulation Of Epithelial Cell Proliferation Positive Regulation Of Metabolic Process Protein Ubiquitination Regulation Of DNA Repair Regulation Of Nucleobase-containing Compound Metabolic Process Protein Modification By Small Protein Conjugation DNA Metabolic Process Nucleobase-containing Compound Metabolic Process Transcription Coactivator Binding Regulation Of Protein Metabolic Process Protein-containing Complex Positive Regulation Of DNA Metabolic Process DNA Damage Response Response To Hypoxia
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