MPP7 and DLGAP4

Number of citations of the paper that reports this interaction (PubMedID 33961781)
97

Data Source:
BioGRID (two hybrid, affinity chromatography technology)

		MPP7	DLGAP4
Description		MAGUK p55 scaffold protein 7	DLG associated protein 4
Image			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Plasma Membrane Cell-cell Junction Adherens Junction Bicellular Tight Junction Cell Cortex Membrane Lateral Plasma Membrane Cell Junction Anchoring Junction MPP7-DLG1-LIN7 Complex	Plasma Membrane Membrane Neuromuscular Junction Synapse Glutamatergic Synapse Cholinergic Synapse Postsynaptic Specialization
	Molecular Function	Protein Binding Protein Domain Specific Binding Signaling Adaptor Activity Cadherin Binding Molecular Adaptor Activity	Protein Binding Molecular Adaptor Activity
	Biological Process	Establishment Of Cell Polarity Positive Regulation Of Protein-containing Complex Assembly Bicellular Tight Junction Assembly Protein Localization To Adherens Junction	Signaling Modulation Of Chemical Synaptic Transmission Regulation Of Synapse Maturation Modification Of Postsynaptic Structure
Pathways		RAC1 GTPase cycle RAC2 GTPase cycle RHOQ GTPase cycle RHOG GTPase cycle RHOJ GTPase cycle RAC3 GTPase cycle	Neurexins and neuroligins Neurexins and neuroligins
Drugs
Diseases
GWAS		Achilles tendon injury ( 33606446) Blood protein levels ( 30072576) Bone mineral density ( 24249740) Bone mineral density (paediatric, skull) ( 24945404) Diverticular disease ( 30177863) Femur bone mineral density x serum urate levels interaction ( 34046847) Glaucoma (primary open-angle) ( 27001270) Heel bone mineral density ( 28869591 30598549) Hippocampal volume ( 21116278) Lumbar spine bone mineral density ( 22504420 29499414) Macular thickness ( 30535121) Obesity-related traits ( 23251661) Psychosis and Alzheimer's disease ( 22005930)	Low density lipoprotein cholesterol levels ( 32154731) Neuroblastoma or malignant cutaneous melanoma ( 31605138)
Interacting Genes		7 interacting genes: DLGAP4 HSBP1 LIN7A LIN7B LIN7C MYSM1 TRIM5	32 interacting genes: ABI2 ALDH16A1 ATPAF2 BIN1 DLG1 DLG3 DLG4 EXOC4 FHL3 FHL5 FKBP6 FYN GRIN1 GRIN2D MAGEA6 MPP7 MTUS2 NCK1 NCK2 NHERF1 NHERF2 PALS1 PLP2 PPP1R1B SH3GL2 SH3RF1 SHANK2 SHANK3 SORBS2 SYNGAP1 UBASH3A UBC
Entrez ID		143098	22839
HPRD ID		14733	16826
Ensembl ID		ENSG00000150054	ENSG00000080845
Uniprot IDs		Q5T2T1	A0A0B4J2C2 Q9Y2H0
PDB IDs		3LRA 3O46
Enriched GO Terms of Interacting Partners?		MPP7-DLG1-LIN7 Complex Regulation Of Synaptic Assembly At Neuromuscular Junction Synaptic Vesicle Transport L27 Domain Binding Neurotransmitter Secretion Protein-macromolecule Adaptor Activity Establishment Of Organelle Localization Regulation Of Synapse Organization Neurotransmitter Transport Postsynaptic Density Membrane Establishment Of Vesicle Localization Vesicle Localization Bicellular Tight Junction Organelle Localization Signal Release Regulation Of Synapse Assembly Cell-cell Junction Exocytosis Presynapse Postsynaptic Membrane Basolateral Plasma Membrane Regulation Of Cell Junction Assembly Regulation Of Developmental Growth Synapse Secretion By Cell Anchoring Junction Omegasome Secretion Regulation Of Developmental Process Regulation Of Growth Establishment Of Localization In Cell Cellular Heat Acclimation Histone H2A Deubiquitinase Activity Protein Domain Specific Binding Cholinergic Synapse Postsynaptic Specialization Metal-dependent Deubiquitinase Activity Transcription Coactivator Activity Axonal Transport Of Mitochondrion Suppression Of Viral Release By Host Protein Transport Modification Of Postsynaptic Structure Morphogenesis Of An Epithelial Sheet Regulation Of Hair Follicle Development Regulation Of Viral Entry Into Host Cell Vesicle-mediated Transport Modification Of Synaptic Structure Host-mediated Suppression Of Symbiont Invasion Mitochondrion Transport Along Microtubule Regulation Of Cellular Component Organization	Ionotropic Glutamate Receptor Binding Postsynaptic Density Learning Receptor Clustering Establishment Or Maintenance Of Apical/basal Cell Polarity Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Protein Localization To Membrane Regulation Of Neuronal Synaptic Plasticity Cytoskeletal Anchor Activity Positive Regulation Of Excitatory Postsynaptic Potential Localization Within Membrane Establishment Or Maintenance Of Cell Polarity Learning Or Memory Associative Learning Adherens Junction Postsynaptic Density Membrane Cognition Positive Regulation Of Actin Filament Polymerization Regulation Of Synaptic Plasticity Modulation Of Excitatory Postsynaptic Potential Glutamate Receptor Signaling Pathway Neuron Projection Phosphatase Binding Response To Glycine Type 2 Metabotropic Glutamate Receptor Binding Postsynaptic Density Organization Synapse Regulation Of Cellular Component Size Glutamatergic Synapse Positive Regulation Of Synaptic Transmission Vocalization Behavior Dendritic Spine Regulation Of Actin Filament Organization Scaffold Protein Binding Type 3 Metabotropic Glutamate Receptor Binding Postsynaptic Specialization Organization Signaling Adaptor Activity Regulation Of Long-term Neuronal Synaptic Plasticity Positive Regulation Of Supramolecular Fiber Organization Positive Regulation Of Protein Polymerization Lateral Loop Protein Localization To Cell Junction Regulation Of Translation Initiation In Response To Endoplasmic Reticulum Stress Synaptic Receptor Adaptor Activity Positive Regulation Of Cytoskeleton Organization Chemical Synaptic Transmission Ionotropic Glutamate Receptor Signaling Pathway Regulation Of Biological Quality Plasma Membrane MPP7-DLG1-LIN7 Complex
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