MPP7 and LIN7C

Number of citations of the paper that reports this interaction (PubMedID 33961781)
97

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology)

		MPP7	LIN7C
Description		MAGUK p55 scaffold protein 7	lin-7 cell polarity scaffold C
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GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Plasma Membrane Cell-cell Junction Adherens Junction Bicellular Tight Junction Cell Cortex Membrane Lateral Plasma Membrane Cell Junction Anchoring Junction MPP7-DLG1-LIN7 Complex	Cytoplasm Plasma Membrane Cell-cell Junction Bicellular Tight Junction Membrane Basolateral Plasma Membrane Synapse Postsynaptic Membrane Anchoring Junction MPP7-DLG1-LIN7 Complex Presynapse Postsynaptic Density Membrane Glutamatergic Synapse
	Molecular Function	Protein Binding Protein Domain Specific Binding Signaling Adaptor Activity Cadherin Binding Molecular Adaptor Activity	Protein Binding Cytoskeletal Protein Binding Protein Domain Specific Binding PDZ Domain Binding Protein-macromolecule Adaptor Activity L27 Domain Binding
	Biological Process	Establishment Of Cell Polarity Positive Regulation Of Protein-containing Complex Assembly Bicellular Tight Junction Assembly Protein Localization To Adherens Junction	Morphogenesis Of An Epithelial Sheet Exocytosis Neurotransmitter Secretion Regulation Of Synaptic Assembly At Neuromuscular Junction Protein Transport Synaptic Vesicle Transport
Pathways		RAC1 GTPase cycle RAC2 GTPase cycle RHOQ GTPase cycle RHOG GTPase cycle RHOJ GTPase cycle RAC3 GTPase cycle	Dopamine Neurotransmitter Release Cycle Neurexins and neuroligins Assembly and cell surface presentation of NMDA receptors
Drugs
Diseases
GWAS		Achilles tendon injury ( 33606446) Blood protein levels ( 30072576) Bone mineral density ( 24249740) Bone mineral density (paediatric, skull) ( 24945404) Diverticular disease ( 30177863) Femur bone mineral density x serum urate levels interaction ( 34046847) Glaucoma (primary open-angle) ( 27001270) Heel bone mineral density ( 28869591 30598549) Hippocampal volume ( 21116278) Lumbar spine bone mineral density ( 22504420 29499414) Macular thickness ( 30535121) Obesity-related traits ( 23251661) Psychosis and Alzheimer's disease ( 22005930)	Bone mineral density (paediatric, skull) ( 24945404) Brain morphology (MOSTest) ( 32665545) Chronotype ( 30696823) Feeling miserable ( 29500382) Feeling nervous ( 29500382) Hip circumference ( 25673412) Lumbar spine bone mineral density ( 22504420) Menarche (age at onset) ( 27182965) Morning person ( 30696823) Survival in pancreatic cancer ( 28470677)
Interacting Genes		7 interacting genes: DLGAP4 HSBP1 LIN7A LIN7B LIN7C MYSM1 TRIM5	9 interacting genes: ABCA1 BAIAP2 DNAJC5 HTR2C KCNJ12 MPP2 MPP7 SNCA YES1
Entrez ID		143098	55327
HPRD ID		14733	17279
Ensembl ID		ENSG00000150054	ENSG00000148943
Uniprot IDs		Q5T2T1	Q9NUP9
PDB IDs		3LRA 3O46	3LRA
Enriched GO Terms of Interacting Partners?		MPP7-DLG1-LIN7 Complex Regulation Of Synaptic Assembly At Neuromuscular Junction Synaptic Vesicle Transport L27 Domain Binding Neurotransmitter Secretion Protein-macromolecule Adaptor Activity Establishment Of Organelle Localization Regulation Of Synapse Organization Neurotransmitter Transport Postsynaptic Density Membrane Establishment Of Vesicle Localization Vesicle Localization Bicellular Tight Junction Organelle Localization Signal Release Regulation Of Synapse Assembly Cell-cell Junction Exocytosis Presynapse Postsynaptic Membrane Basolateral Plasma Membrane Regulation Of Cell Junction Assembly Regulation Of Developmental Growth Synapse Secretion By Cell Anchoring Junction Omegasome Secretion Regulation Of Developmental Process Regulation Of Growth Establishment Of Localization In Cell Cellular Heat Acclimation Histone H2A Deubiquitinase Activity Protein Domain Specific Binding Cholinergic Synapse Postsynaptic Specialization Metal-dependent Deubiquitinase Activity Transcription Coactivator Activity Axonal Transport Of Mitochondrion Suppression Of Viral Release By Host Protein Transport Modification Of Postsynaptic Structure Morphogenesis Of An Epithelial Sheet Regulation Of Hair Follicle Development Regulation Of Viral Entry Into Host Cell Vesicle-mediated Transport Modification Of Synaptic Structure Host-mediated Suppression Of Symbiont Invasion Mitochondrion Transport Along Microtubule Regulation Of Cellular Component Organization	Positive Regulation Of Protein-containing Complex Assembly Plasma Membrane Regulation Of Transport Regulation Of Protein-containing Complex Assembly Signal Release Positive Regulation Of Cellular Component Biogenesis Regulation Of Synaptic Plasticity Synaptic Vesicle Exocytosis Cellular Response To Retinoic Acid Cellular Component Assembly Sphingolipid Floppase Activity Membrane Protein Complex Oligomerization Long-term Synaptic Potentiation Excitatory Postsynaptic Potential Dendritic Shaft Response To Desipramine Presynapse Negative Regulation Of Norepinephrine Uptake Phospholipase D Inhibitor Activity Response To Growth Factor Cellular Response To Growth Factor Stimulus Positive Regulation Of SNARE Complex Assembly Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission Dendritic Spine Cytoplasm Neuron Projection Branch Point Regulation Of Biological Quality Response To Vitamin B3 Secretion By Cell Positive Regulation Of High-density Lipoprotein Particle Assembly Apolipoprotein A-I Receptor Activity 1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine Binding Protein Tetramerization Vesicle-mediated Transport In Synapse Regulation Of Norepinephrine Uptake Negative Regulation Of Mitochondrial Electron Transport, NADH To Ubiquinone Positive Regulation Of Hydrogen Peroxide Catabolic Process Protein Localization To Cell Junction Response To Retinoic Acid Regulation Of Multicellular Organismal Process Regulation Of High-density Lipoprotein Particle Assembly Gq/11-coupled Serotonin Receptor Activity Positive Regulation Of Phosphatidylinositol Biosynthetic Process Regulation Of Postsynaptic Membrane Potential Regulation Of Membrane Potential Negative Regulation Of Serotonin Uptake Neuron Apoptotic Process Transporter Regulator Activity Regulated Exocytosis Negative Regulation Of Chaperone-mediated Autophagy
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