MPP7

Description		MAGUK p55 scaffold protein 7
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GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Plasma Membrane Cell-cell Junction Adherens Junction Bicellular Tight Junction Cell Cortex Membrane Lateral Plasma Membrane Cell Junction Anchoring Junction MPP7-DLG1-LIN7 Complex
	Molecular Function	Protein Binding Protein Domain Specific Binding Signaling Adaptor Activity Cadherin Binding Molecular Adaptor Activity
	Biological Process	Establishment Of Cell Polarity Positive Regulation Of Protein-containing Complex Assembly Bicellular Tight Junction Assembly Protein Localization To Adherens Junction
Pathways		RAC1 GTPase cycle RAC2 GTPase cycle RHOQ GTPase cycle RHOG GTPase cycle RHOJ GTPase cycle RAC3 GTPase cycle
Drugs
Diseases
GWAS		Achilles tendon injury ( 33606446) Blood protein levels ( 30072576) Bone mineral density ( 24249740) Bone mineral density (paediatric, skull) ( 24945404) Diverticular disease ( 30177863) Femur bone mineral density x serum urate levels interaction ( 34046847) Glaucoma (primary open-angle) ( 27001270) Heel bone mineral density ( 28869591 30598549) Hippocampal volume ( 21116278) Lumbar spine bone mineral density ( 22504420 29499414) Macular thickness ( 30535121) Obesity-related traits ( 23251661) Psychosis and Alzheimer's disease ( 22005930)
Interacting Genes		7 interacting genes: DLGAP4 HSBP1 LIN7A LIN7B LIN7C MYSM1 TRIM5
Entrez ID		143098
HPRD ID		14733
Ensembl ID		ENSG00000150054
Uniprot IDs		Q5T2T1
PDB IDs		3LRA 3O46
Enriched GO Terms of Interacting Partners?		MPP7-DLG1-LIN7 Complex Regulation Of Synaptic Assembly At Neuromuscular Junction Synaptic Vesicle Transport L27 Domain Binding Neurotransmitter Secretion Protein-macromolecule Adaptor Activity Establishment Of Organelle Localization Regulation Of Synapse Organization Neurotransmitter Transport Postsynaptic Density Membrane Establishment Of Vesicle Localization Vesicle Localization Bicellular Tight Junction Organelle Localization Signal Release Regulation Of Synapse Assembly Cell-cell Junction Exocytosis Presynapse Postsynaptic Membrane Basolateral Plasma Membrane Regulation Of Cell Junction Assembly Regulation Of Developmental Growth Synapse Secretion By Cell Anchoring Junction Omegasome Secretion Regulation Of Developmental Process Regulation Of Growth Establishment Of Localization In Cell Cellular Heat Acclimation Histone H2A Deubiquitinase Activity Protein Domain Specific Binding Cholinergic Synapse Postsynaptic Specialization Metal-dependent Deubiquitinase Activity Transcription Coactivator Activity Axonal Transport Of Mitochondrion Suppression Of Viral Release By Host Protein Transport Modification Of Postsynaptic Structure Morphogenesis Of An Epithelial Sheet Regulation Of Hair Follicle Development Regulation Of Viral Entry Into Host Cell Vesicle-mediated Transport Modification Of Synaptic Structure Host-mediated Suppression Of Symbiont Invasion Mitochondrion Transport Along Microtubule Regulation Of Cellular Component Organization
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