MYH2 and PTK2B

Number of citations of the paper that reports this interaction (PMID 10082674)
6

Data Source:
HPRD (in vitro)

		MYH2	PTK2B
Gene Name		myosin, heavy chain 2, skeletal muscle, adult	protein tyrosine kinase 2 beta
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Golgi Apparatus Actomyosin Contractile Ring Cytosol Muscle Myosin Complex Cell-cell Junction Myofibril Sarcomere A Band Myosin Filament Protein Complex	Nucleus Nucleoplasm Cytoplasm Cytosol Cytoskeleton Focal Adhesion Cell Cortex Postsynaptic Density N-methyl-D-aspartate Selective Glutamate Receptor Complex Lamellipodium Axon Dendrite Growth Cone Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Neuronal Cell Body Cell Body Membrane Raft Perinuclear Region Of Cytoplasm Apical Dendrite
	Molecular Function	Microfilament Motor Activity Actin Binding Protein Binding Calmodulin Binding ATP Binding	Calmodulin-dependent Protein Kinase Activity Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Signal Transducer Activity N-methyl-D-aspartate Selective Glutamate Receptor Activity Receptor Binding Protein Binding ATP Binding Protein Complex Binding 3-phosphoinositide-dependent Protein Kinase Binding
	Biological Process	Plasma Membrane Repair Muscle Contraction Metabolic Process Response To Activity Muscle Filament Sliding Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Innate Immune Response Membrane Organization	MAPK Cascade Angiogenesis Oocyte Maturation Response To Hypoxia Positive Regulation Of Cell-matrix Adhesion Sprouting Angiogenesis Marginal Zone B Cell Differentiation Protein Complex Assembly Protein Phosphorylation Apoptotic Process Response To Stress Cellular Defense Response Response To Osmotic Stress Signal Transduction Cell Surface Receptor Signaling Pathway Signal Complex Assembly Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Integrin-mediated Signaling Pathway Positive Regulation Of Cell Proliferation Negative Regulation Of Cell Proliferation Regulation Of Cell Shape Response To Mechanical Stimulus Response To Hormone Response To Glucose Response To Lithium Ion Positive Regulation Of Endothelial Cell Migration Negative Regulation Of Muscle Cell Apoptotic Process Regulation Of CGMP-mediated Signaling Regulation Of Macrophage Chemotaxis Positive Regulation Of Neuron Projection Development Glial Cell Proliferation Peptidyl-tyrosine Phosphorylation Regulation Of Cell Adhesion Positive Regulation Of Cell Growth Positive Regulation Of Cell Migration Negative Regulation Of Bone Mineralization Regulation Of CGMP Biosynthetic Process Positive Regulation Of Actin Filament Polymerization Neuron Projection Development Activation Of Rac GTPase Activity Regulation Of Inositol Trisphosphate Biosynthetic Process Tumor Necrosis Factor-mediated Signaling Pathway Ionotropic Glutamate Receptor Signaling Pathway Response To Immobilization Stress Peptidyl-tyrosine Autophosphorylation Response To Cocaine Response To Drug Response To Hydrogen Peroxide Activation Of Janus Kinase Activity Negative Regulation Of Apoptotic Process Stress Fiber Assembly Negative Regulation Of Potassium Ion Transport Positive Regulation Of JUN Kinase Activity Negative Regulation Of Neuron Apoptotic Process Blood Vessel Endothelial Cell Migration Positive Regulation Of Phosphatidylinositol 3-kinase Activity Innate Immune Response Regulation Of Nitric Oxide Biosynthetic Process Bone Resorption Response To Ethanol Negative Regulation Of Myeloid Cell Differentiation Positive Regulation Of Translation Positive Regulation Of Angiogenesis Positive Regulation Of Protein Kinase Activity Positive Regulation Of JNK Cascade Protein Autophosphorylation Vascular Endothelial Growth Factor Receptor Signaling Pathway Focal Adhesion Assembly Positive Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Calcium-mediated Signaling Positive Regulation Of Nitric-oxide Synthase Activity Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Response To CAMP Response To Calcium Ion Positive Regulation Of Synaptic Transmission, Glutamatergic Long-term Synaptic Potentiation Chemokine-mediated Signaling Pathway Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Retinoic Acid Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Regulation Of Establishment Of Cell Polarity Regulation Of Actin Cytoskeleton Reorganization Regulation Of N-methyl-D-aspartate Selective Glutamate Receptor Activity Positive Regulation Of Reactive Oxygen Species Metabolic Process Positive Regulation Of Excitatory Postsynaptic Membrane Potential Positive Regulation Of B Cell Chemotaxis
Pathways		Translocation of GLUT4 to the plasma membrane Fcgamma receptor (FCGR) dependent phagocytosis Regulation of actin dynamics for phagocytic cup formation Innate Immune System	Signaling by Interleukins Signaling by VEGF Cytokine Signaling in Immune system Interleukin-2 signaling Signal regulatory protein (SIRP) family interactions VEGFA-VEGFR2 Pathway
Drugs			Leflunomide Genistein 4-{[4-{[(1R,2R)-2-(dimethylamino)cyclopentyl]amino}-5-(trifluoromethyl)pyrimidin-2-yl]amino}-N-methylbenzenesulfonamide
Diseases
GWAS			Dental caries ( 23259602)
Protein-Protein Interactions		6 interactors: AMPD1 DGKD OBSCN PRKCE PTK2B S100A4	70 interactors: ARHGAP21 ARHGAP5 ASAP1 ASAP2 BCAR1 CBL CCR5 CRK DCC DLG3 DLG4 DLGAP3 EFS EGFR ERBB2 ERBB3 EWSR1 FGFR2 FGFR3 FLT1 FYN GNA13 GRB2 GRIN2A GSN IL7R ITGB2 ITGB3 JAK1 JAK2 JAK3 KCNA2 LCK LPXN LYN MAP3K4 MAPT MATK MCAM MYH2 NEDD9 NPHP1 PDCD6IP PDPK1 PIK3R1 PITPNM1 PITPNM2 PITPNM3 PRKCD PTK2 PTPN11 PTPN12 PTPN6 PXN RASA1 RB1CC1 SH2D3C SHC1 SKAP2 SLC2A1 SNCA SORBS2 SRC STAP1 STAT3 SYK TGFB1I1 TLN1 VAV1 ZAP70
Entrez ID		4620	2185
HPRD ID		01173	03131
Ensembl ID		ENSG00000125414	ENSG00000120899
Uniprot IDs		Q567P6 Q9UKX2	Q14289
PDB IDs			2FO6 2LK4 3CC6 3ET7 3FZO 3FZP 3FZR 3FZS 3FZT 3GM1 3GM2 3GM3 3H3C 3U3C 3U3F 4EKU 4H1J 4H1M
Enriched GO Terms of Interacting Partners?		Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Response To Organic Substance Phosphate-containing Compound Metabolic Process Positive Regulation Of Epithelial Cell Migration Response To Ammonium Ion Negative Regulation Of Ion Transport Positive Regulation Of Cellular Glucuronidation Positive Regulation Of Actin Filament Polymerization Positive Regulation Of Synaptic Transmission Actomyosin Structure Organization Regulation Of Receptor Activity Positive Regulation Of Cell-substrate Adhesion Positive Regulation Of Protein Polymerization Regulation Of Intracellular Signal Transduction Cell Activation Regulation Of CGMP-mediated Signaling Marginal Zone B Cell Differentiation Positive Regulation Of B Cell Chemotaxis TRAM-dependent Toll-like Receptor 4 Signaling Pathway Phosphorylation Response To Ethanol Intracellular Signal Transduction Regulation Of Ion Transmembrane Transporter Activity Regulation Of Epithelial Cell Migration Response To Alkaloid Regulation Of Transmembrane Transporter Activity Regulation Of Carbohydrate Metabolic Process Leukocyte Activation Involved In Immune Response Positive Regulation Of Cytosolic Calcium Ion Concentration Regulation Of Ion Homeostasis Positive Regulation Of Intracellular Signal Transduction Protein Localization To M-band Positive Regulation Of Protein Complex Assembly Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of Actin Filament Polymerization Cytosolic Calcium Ion Homeostasis Activation Of Janus Kinase Activity Platelet Activation Regulation Of Cell-substrate Adhesion Positive Regulation Of Cytoskeleton Organization Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Filament Length Regulation Of Peptidyl-tyrosine Phosphorylation Neurotrophin TRK Receptor Signaling Pathway Apoptotic Process Neurotrophin Signaling Pathway Regulation Of I-kappaB Kinase/NF-kappaB Signaling	Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Cell Communication Signaling Movement Of Cell Or Subcellular Component Epidermal Growth Factor Receptor Signaling Pathway Peptidyl-tyrosine Phosphorylation ERBB Signaling Pathway Response To Wounding Signal Transduction Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Signaling Regulation Of Signal Transduction Locomotion Wound Healing Immune Response-regulating Signaling Pathway Innate Immune Response Fc Receptor Signaling Pathway Positive Regulation Of Signal Transduction Platelet Activation Regulation Of Immune Response Cell Migration Cellular Response To Stimulus Neurotrophin TRK Receptor Signaling Pathway Cell Activation Cellular Response To Fibroblast Growth Factor Stimulus Neurotrophin Signaling Pathway Response To Fibroblast Growth Factor Cell Motility Protein Autophosphorylation Fibroblast Growth Factor Receptor Signaling Pathway Cellular Response To Growth Factor Stimulus Blood Coagulation Cellular Response To Peptide Hormone Stimulus Hemostasis Cell Surface Receptor Signaling Pathway Response To Growth Factor Cellular Response To Peptide Immune Response Regulation Of Immune System Process Cellular Response To Organonitrogen Compound Defense Response Peptidyl-tyrosine Autophosphorylation Positive Regulation Of Catalytic Activity Response To Stress Regulation Of Intracellular Signal Transduction Regulation Of Cell Adhesion Vascular Endothelial Growth Factor Receptor Signaling Pathway Leukocyte Migration Response To Organonitrogen Compound
Tagcloud ?		breakpoint breaks coliai cryb1 d17s1 d17s19 d17s6 d17z erba1 gaa galk gcsf ghc hox2 hybrids isoenzymes mpo myh1 ngfr ngl probes pter qter regionally rnp2 rnu2 tk1 transfectant um	advent broadly cass4 debilitating driving emphasized fact genotypic gwas inform interacting intriguingly limit load microtubule nedd9 occurrences oncogenesis options paralogous partners pathophysiology phenotypic reciprocally reflects scaffolding snps stabilization viable
Tagcloud (Difference) ?		breakpoint breaks coliai cryb1 d17s1 d17s19 d17s6 d17z erba1 gaa galk gcsf ghc hox2 hybrids isoenzymes mpo myh1 ngfr ngl probes pter qter regionally rnp2 rnu2 tk1 transfectant um	advent broadly cass4 debilitating driving emphasized fact genotypic gwas inform interacting intriguingly limit load microtubule nedd9 occurrences oncogenesis options paralogous partners pathophysiology phenotypic reciprocally reflects scaffolding snps stabilization viable
Tagcloud (Intersection) ?