MYH2 and OBSCN

Number of citations of the paper that reports this interaction (PubMedID 15013951)
0

Data Source:
HPRD (in vivo)

		MYH2	OBSCN
Description		myosin heavy chain 2	obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Muscle Myosin Complex Cell-cell Junction Myosin Complex Myosin II Complex Myofibril Sarcomere Myosin Filament Protein-containing Complex Supramolecular Fiber	Nucleus Cytoplasm Cytosol Plasma Membrane Membrane Nuclear Body Myofibril Z Disc M Band Sarcolemma
	Molecular Function	Microfilament Motor Activity Nucleotide Binding Cytoskeletal Motor Activity Actin Binding Protein Binding Calmodulin Binding ATP Binding Actin Filament Binding	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Guanyl-nucleotide Exchange Factor Activity Protein Binding Calmodulin Binding ATP Binding Phosphatidylinositol-4,5-bisphosphate Binding Phosphatidylinositol-3,4,5-trisphosphate Binding Lipid Binding Structural Constituent Of Muscle Phosphatidylinositol-5-phosphate Binding Kinase Activity Transferase Activity Ankyrin Binding Titin Binding Phosphatidylinositol-3-phosphate Binding Phosphatidylinositol-3,4-bisphosphate Binding Metal Ion Binding Phosphatidylinositol-4-phosphate Binding Protein Serine Kinase Activity Phosphatidylinositol Bisphosphate Binding
	Biological Process	Muscle Contraction Muscle Filament Sliding	Cell Differentiation Protein Localization To M-band Sarcomere Organization Regulation Of Small GTPase Mediated Signal Transduction Regulation Of Intracellular Signal Transduction
Pathways		Regulation of actin dynamics for phagocytic cup formation FCGR3A-mediated phagocytosis
Drugs
Diseases
GWAS			Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Estimated glomerular filtration rate ( 31152163) Non-Richardson's syndrome vs Richardson's syndrome in progressive supranuclear palsy ( 30066433) PR interval ( 30046033 32439900)
Interacting Genes		7 interacting genes: AMPD1 DGKD DUX4L9 OBSCN PRKCE PTK2B S100A4	8 interacting genes: ANK1 ANK2 BRCA1 CALM1 DNAJB5 MTDH MYH2 TTN
Entrez ID		4620	84033
HPRD ID		01173	10551
Ensembl ID		ENSG00000125414	ENSG00000154358
Uniprot IDs		Q9UKX2	A6NGQ3
PDB IDs
Enriched GO Terms of Interacting Partners?		Signaling Receptor Activator Activity Kinase Activity AMP Deaminase Activity Phosphate-containing Compound Metabolic Process ATP Binding Positive Regulation Of Protein Polymerization Regulation Of Actin Filament Polymerization Neurotransmitter Receptor Regulator Activity Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Positive Regulation Of B Cell Chemotaxis Regulation Of Sequestering Of Calcium Ion Positive Regulation Of Actin Filament Polymerization Negative Regulation Of Monoatomic Ion Transport Phosphorylation Protein Kinase Activity Regulation Of Intracellular Signal Transduction Positive Regulation Of Cell-substrate Adhesion TRAM-dependent Toll-like Receptor 4 Signaling Pathway Ethanol Binding Negative Regulation Of Phospholipase C/protein Kinase C Signal Transduction Positive Regulation Of Clathrin-dependent Endocytosis Protein Localization To M-band Regulation Of Actin Polymerization Or Depolymerization Regulation Of Calcium Ion Transmembrane Transport Cell Activation Involved In Immune Response Regulation Of Actin Filament Length Leukocyte Activation Involved In Immune Response Positive Regulation Of Synaptic Transmission Cell Activation Activation Of Janus Kinase Activity Diacylglycerol-dependent, Calcium-independent Serine/threonine Kinase Activity Toxin Catabolic Process IMP Salvage GMP Salvage Perinuclear Region Of Cytoplasm Positive Regulation Of Supramolecular Fiber Organization Positive Regulation Of Signal Transduction Positive Regulation Of Mucus Secretion Positive Regulation Of Cytoskeleton Organization Diacylglycerol Catabolic Process Deaminase Activity NMDA Selective Glutamate Receptor Complex Transferase Activity Signal Complex Assembly Positive Regulation Of Cell Communication Regulation Of Signal Transduction Peptidyl-tyrosine Autophosphorylation Positive Regulation Of Signaling Regulation Of Cell-substrate Adhesion Regulation Of Calcium Ion Transport	M Band Transmembrane Transporter Binding Enzyme Binding Z Disc A Band Actin-myosin Filament Sliding Muscle Filament Sliding Cytoskeletal Anchor Activity Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Spectrin Binding Regulation Of Cardiac Muscle Cell Action Potential Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Actin-mediated Cell Contraction Condensed Nuclear Chromosome Protein-containing Complex Sarcomere Regulation Of Action Potential Actin Filament-based Movement Protein Localization To T-tubule Structural Constituent Of Cytoskeleton ATPase Binding Protein Kinase Binding Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Protein Localization To M-band Regulation Of Cardiac Muscle Contraction Regulation Of Striated Muscle Contraction Atrial Cardiac Muscle Cell To AV Node Cell Communication Histone H2AK127 Ubiquitin Ligase Activity Histone H2AK129 Ubiquitin Ligase Activity BRCA1-BARD1 Complex Negative Regulation Of High Voltage-gated Calcium Channel Activity Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Titin-telethonin Complex Structural Molecule Activity Conferring Elasticity Sarcomerogenesis Regulation Of Heart Rate Sarcolemma Skeletal Muscle Myosin Thick Filament Assembly Regulation Of Sequestering Of Calcium Ion Maintenance Of Epithelial Cell Apical/basal Polarity Structural Molecule Activity Ankyrin-1 Complex Regulation Of Muscle Contraction Positive Regulation Of Potassium Ion Import Across Plasma Membrane Regulation Of Atrial Cardiac Muscle Cell Action Potential Potassium Channel Activator Activity Calcium-mediated Signaling SA Node Cell Action Potential SA Node Cell To Atrial Cardiac Muscle Cell Communication
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