RPLP0 and KRI1

Number of citations of the paper that reports this interaction (PubMedID 33961781)
97

Data Source:
BioGRID (affinity chromatography technology)
HPRD (two hybrid)

		RPLP0	KRI1
Description		ribosomal protein lateral stalk subunit P0	KRI1 homolog
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Endoplasmic Reticulum Cytosol Ribosome Focal Adhesion Postsynaptic Density Membrane Cytosolic Large Ribosomal Subunit Cytosolic Ribosome Cytoplasmic Ribonucleoprotein Granule Extracellular Exosome Postsynapse Ribonucleoprotein Complex	Nucleolus 90S Preribosome
	Molecular Function	RNA Binding Structural Constituent Of Ribosome Protein Binding Large Ribosomal Subunit RRNA Binding	RNA Binding
	Biological Process	Cytoplasmic Translation Translation Ribosome Biogenesis	Endonucleolytic Cleavage In ITS1 To Separate SSU-rRNA From 5.8S RRNA And LSU-rRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA)
Pathways		L13a-mediated translational silencing of Ceruloplasmin expression Peptide chain elongation SRP-dependent cotranslational protein targeting to membrane SRP-dependent cotranslational protein targeting to membrane Viral mRNA Translation Selenocysteine synthesis Major pathway of rRNA processing in the nucleolus and cytosol Formation of a pool of free 40S subunits GTP hydrolysis and joining of the 60S ribosomal subunit Eukaryotic Translation Termination Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation Regulation of expression of SLITs and ROBOs Response of EIF2AK4 (GCN2) to amino acid deficiency Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA
Drugs
Diseases
GWAS		Waist circumference adjusted for body mass index ( 28552196)	Basophil count ( 32888494) Basophil percentage of white cells ( 32888494) Lymphocyte percentage of white cells ( 32888494) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Monocyte percentage of white cells ( 32888494) Neutrophil count ( 32888494) Neutrophil percentage of white cells ( 32888494) Red blood cell count ( 32888494) Red cell distribution width ( 32888494) White blood cell count ( 32888494)
Interacting Genes		15 interacting genes: CSNK2A1 ERG EXOSC8 GAS7 KRI1 LINC00632 OGT PAFAH1B2 PPM1A PRPF40A PTEN SMAD3 STAU1 USP7 YWHAQ	4 interacting genes: CEP70 LLPH RPLP0 USP7
Entrez ID		6175	65095
HPRD ID		01610	10969
Ensembl ID		ENSG00000089157	ENSG00000129347
Uniprot IDs		P05388	A0A494C108 Q8N9T8
PDB IDs		4V6W 4V6X 5AJ0 6OLG 6ZM7 6ZME 6ZMI 6ZMO 8G5Z 8G60 8G6J 8K2C 8UKB 8XSX 8XSY 8XSZ 8YOO 8YOP
Enriched GO Terms of Interacting Partners?		Symbiont-mediated Disruption Of Host Cell PML Body Negative Regulation Of Protein Catabolic Process Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteasomal Protein Catabolic Process Protein Stabilization Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Rhythmic Process Negative Regulation Of Macromolecule Metabolic Process PML Body Negative Regulation Of Protein Metabolic Process Negative Regulation Of Metabolic Process Sin3-type Complex Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteolysis Regulation Of Protein Catabolic Process Regulation Of Protein Stability Negative Regulation Of Biosynthetic Process Positive Regulation Of Wnt Signaling Pathway Negative Regulation Of Gene Expression R-SMAD Binding Negative Regulation Of Catabolic Process Regulation Of Proteolysis Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Identical Protein Binding Positive Regulation Of Autophagy Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Translational Initiation Negative Regulation Of Lung Blood Pressure Nuclear Mineralocorticoid Receptor Binding Negative Regulation Of Synaptic Vesicle Clustering Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Regulation Of Cellular Localization Regulation Of Gluconeogenesis Cytosol Positive Regulation Of Catabolic Process Membraneless Organelle Assembly Regulation Of Gene Expression Negative Regulation Of Osteoblast Differentiation Regulation Of Cell Junction Assembly Positive Regulation Of Transforming Growth Factor Beta3 Production Regulation Of Focal Adhesion Assembly Negative Regulation Of Wound Healing Positive Regulation Of Nucleocytoplasmic Transport Cellular Response To Glucose Stimulus Regulation Of Intracellular Transport Response To Transforming Growth Factor Beta	Large Ribosomal Subunit RRNA Binding Regulation Of Establishment Of Protein Localization To Chromosome Regulation Of Establishment Of Protein Localization To Telomere Symbiont-mediated Disruption Of Host Cell PML Body Regulation Of Retrograde Transport, Endosome To Golgi Basal RNA Polymerase II Transcription Machinery Binding Monoubiquitinated Protein Deubiquitination DNA Alkylation Repair Transcription-coupled Nucleotide-excision Repair Dendrite Extension
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