POLR2D and NR5A2

Number of citations of the paper that reports this interaction (PMID 15604093)
36

Data Source:
HPRD (two hybrid)

		POLR2D	NR5A2
Gene Name		polymerase (RNA) II (DNA directed) polypeptide D	nuclear receptor subfamily 5, group A, member 2
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Gene Ontology Annotations	Cellular Component	Cytoplasmic MRNA Processing Body Nucleus Nucleoplasm DNA-directed RNA Polymerase II, Core Complex	Nucleus Nucleoplasm Cytoplasm
	Molecular Function	Nucleotide Binding Single-stranded DNA Binding Single-stranded RNA Binding DNA-directed RNA Polymerase Activity Translation Initiation Factor Binding	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription DNA Binding Sequence-specific DNA Binding Transcription Factor Activity RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding Transcription Factor Activity Steroid Hormone Receptor Activity Ligand-activated Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Activity Protein Binding Phospholipid Binding Zinc Ion Binding Sequence-specific DNA Binding Transcription Regulatory Region DNA Binding
	Biological Process	Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay MRNA Splicing, Via Spliceosome DNA Repair Transcription-coupled Nucleotide-excision Repair Nucleotide-excision Repair Transcription From RNA Polymerase II Promoter Transcription Initiation From RNA Polymerase II Promoter Transcription Elongation From RNA Polymerase II Promoter 7-methylguanosine MRNA Capping RNA Splicing Gene Expression Viral Process MRNA Export From Nucleus In Response To Heat Stress Recruitment Of 3'-end Processing Factors To RNA Polymerase II Holoenzyme Complex PiRNA Metabolic Process Somatic Stem Cell Maintenance Positive Regulation Of Translational Initiation Positive Regulation Of Viral Transcription	Regulation Of Transcription, DNA-templated Transcription Initiation From RNA Polymerase II Promoter Bile Acid Metabolic Process Embryo Development Gene Expression Intracellular Receptor Signaling Pathway Endocrine Pancreas Development Regulation Of Cell Proliferation Homeostatic Process Cholesterol Homeostasis Steroid Hormone Mediated Signaling Pathway Positive Regulation Of Viral Genome Replication Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter
Pathways		RNA Polymerase II Promoter Escape mRNA Splicing Formation of HIV-1 elongation complex containing HIV-1 Tat PIWI-interacting RNA (piRNA) biogenesis Nucleotide Excision Repair RNA Polymerase II Transcription Pre-Initiation And Promoter Opening RNA Polymerase II Transcription Abortive elongation of HIV-1 transcript in the absence of Tat HIV Infection Regulatory RNA pathways Formation of the Early Elongation Complex Tat-mediated elongation of the HIV-1 transcript Tat-mediated HIV elongation arrest and recovery Formation of transcription-coupled NER (TC-NER) repair complex RNA Pol II CTD phosphorylation and interaction with CE RNA Polymerase II Pre-transcription Events Dual incision reaction in TC-NER Influenza Life Cycle HIV elongation arrest and recovery HIV Life Cycle HIV Transcription Initiation Influenza Viral RNA Transcription and Replication RNA Pol II CTD phosphorylation and interaction with CE Transcriptional regulation of pluripotent stem cells RNA Polymerase II HIV Promoter Escape HIV Transcription Elongation POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation Transcriptional regulation by small RNAs Processing of Capped Intron-Containing Pre-mRNA mRNA Capping mRNA Splicing - Minor Pathway mRNA Splicing - Major Pathway MicroRNA (miRNA) biogenesis Influenza Infection Pausing and recovery of Tat-mediated HIV elongation Late Phase of HIV Life Cycle Formation of RNA Pol II elongation complex RNA Polymerase II Transcription Initiation And Promoter Clearance Pausing and recovery of HIV elongation Formation of HIV elongation complex in the absence of HIV Tat Transcription-coupled NER (TC-NER) Viral Messenger RNA Synthesis Formation of the HIV-1 Early Elongation Complex RNA Polymerase II Transcription Initiation Transcription of the HIV genome RNA Polymerase II Transcription Elongation
Drugs
Diseases
GWAS			Pancreatic cancer ( 20101243)
Protein-Protein Interactions		16 interactors: ATF7IP EMX1 ESR1 HOXC9 IKBKG NR5A2 POLR2A POLR2B POLR2C POLR2E POLR2G POLR2H POLR2K POLR2L TRIM29 ZSCAN1	19 interactors: ALB BCKDK COPS5 EDF1 FTH1 NCOA1 NCOA3 NPPA NR0B2 NRIP1 NSD1 PNRC1 PNRC2 POLR2D PROX1 RAD54L2 SMARCD3 SRC UBE2I
Entrez ID		5433	2494
HPRD ID		16191	06830
Ensembl ID		ENSG00000144231	ENSG00000116833
Uniprot IDs		E9PB93 E9PHV4 O15514	B4E2P3 F1D8R9 O00482
PDB IDs		2C35	1YOK 1YUC 1ZDU 2A66 3PLZ 3TX7 4DOR 4DOS 4IS8
Enriched GO Terms of Interacting Partners?		7-methylguanosine MRNA Capping PiRNA Metabolic Process 7-methylguanosine RNA Capping Positive Regulation Of Viral Process Transcription-coupled Nucleotide-excision Repair Positive Regulation Of Viral Transcription Transcription Initiation From RNA Polymerase II Promoter Transcription Elongation From RNA Polymerase II Promoter DNA-templated Transcription, Initiation Somatic Stem Cell Maintenance Regulation Of Viral Transcription Regulation Of Viral Process DNA-templated Transcription, Elongation Nucleotide-excision Repair Transcription From RNA Polymerase II Promoter Transcription, DNA-templated RNA Biosynthetic Process Stem Cell Maintenance Viral Process MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions RNA Metabolic Process Stem Cell Development Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Gene Expression Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Cellular Macromolecule Biosynthetic Process Stem Cell Differentiation Macromolecule Biosynthetic Process Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process RNA Splicing MRNA Processing Termination Of RNA Polymerase III Transcription Transcription Elongation From RNA Polymerase III Promoter Nucleobase-containing Compound Metabolic Process NcRNA Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process MRNA Metabolic Process Cellular Response To DNA Damage Stimulus Cellular Nitrogen Compound Metabolic Process RNA Processing Positive Regulation Of Type I Interferon Production DNA Repair Termination Of RNA Polymerase I Transcription	Transcription, DNA-templated RNA Biosynthetic Process Positive Regulation Of Gene Expression Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process RNA Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Gene Expression Regulation Of Nucleic Acid-templated Transcription Cellular Macromolecule Biosynthetic Process Positive Regulation Of Transcription, DNA-templated Intracellular Steroid Hormone Receptor Signaling Pathway Macromolecule Biosynthetic Process Regulation Of Gene Expression Positive Regulation Of Metabolic Process Regulation Of Transcription, DNA-templated Nucleobase-containing Compound Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Nitrogen Compound Metabolic Process Androgen Receptor Signaling Pathway Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Cellular Nitrogen Compound Metabolic Process Intracellular Receptor Signaling Pathway Regulation Of Metabolic Process Cellular Metabolic Process Metabolic Process Regulation Of Cellular Process Transcription From RNA Polymerase II Promoter Peptidyl-lysine Modification Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Negative Regulation Of Transcription, DNA-templated Labyrinthine Layer Morphogenesis Positive Regulation Of Organelle Assembly Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Embryonic Placenta Morphogenesis Gland Morphogenesis Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription Initiation From RNA Polymerase II Promoter Response To Nutrient Levels Mammary Gland Development Anatomical Structure Development Negative Regulation Of Gene Expression Response To Extracellular Stimulus Negative Regulation Of Biosynthetic Process
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