POLR2D and HOXC9

Number of citations of the paper that reports this interaction (PubMedID 20211142)
41

Data Source:
BioGRID (two hybrid)

		POLR2D	HOXC9
Description		RNA polymerase II subunit D	homeobox C9
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GO Annotations	Cellular Component	DNA-directed RNA Polymerase Complex Nucleus Nucleoplasm RNA Polymerase II, Core Complex Cytosol Nuclear Speck RNA Polymerase Complex	Chromatin Nucleus Nucleoplasm Aggresome Transcription Repressor Complex
	Molecular Function	Nucleotide Binding Protein Binding Translation Initiation Factor Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	DNA-templated Transcription Initiation Transcription By RNA Polymerase II Transcription Initiation At RNA Polymerase II Promoter	DNA-templated Transcription Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Anterior/posterior Pattern Specification Proximal/distal Pattern Formation Negative Regulation Of Cell Cycle Embryonic Skeletal System Morphogenesis Embryonic Skeletal System Development
Pathways		Formation of RNA Pol II elongation complex Formation of the Early Elongation Complex Formation of HIV elongation complex in the absence of HIV Tat Formation of the HIV-1 Early Elongation Complex RNA Pol II CTD phosphorylation and interaction with CE during HIV infection HIV Transcription Initiation RNA Polymerase II HIV Promoter Escape Transcription of the HIV genome Formation of HIV-1 elongation complex containing HIV-1 Tat Formation of HIV-1 elongation complex containing HIV-1 Tat Pausing and recovery of Tat-mediated HIV elongation Abortive elongation of HIV-1 transcript in the absence of Tat Tat-mediated HIV elongation arrest and recovery Tat-mediated elongation of the HIV-1 transcript HIV elongation arrest and recovery Pausing and recovery of HIV elongation Viral Messenger RNA Synthesis MicroRNA (miRNA) biogenesis Transcriptional regulation by small RNAs PIWI-interacting RNA (piRNA) biogenesis Activation of anterior HOX genes in hindbrain development during early embryogenesis RNA Polymerase II Pre-transcription Events Formation of TC-NER Pre-Incision Complex Transcription-Coupled Nucleotide Excision Repair (TC-NER) Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER TP53 Regulates Transcription of DNA Repair Genes FGFR2 alternative splicing RNA polymerase II transcribes snRNA genes RNA polymerase II transcribes snRNA genes mRNA Capping mRNA Splicing - Major Pathway mRNA Splicing - Minor Pathway Processing of Capped Intron-Containing Pre-mRNA RNA Polymerase II Promoter Escape RNA Polymerase II Transcription Pre-Initiation And Promoter Opening RNA Polymerase II Transcription Initiation RNA Polymerase II Transcription Elongation RNA Polymerase II Transcription Initiation And Promoter Clearance RNA Pol II CTD phosphorylation and interaction with CE Signaling by FGFR2 IIIa TM Estrogen-dependent gene expression Inhibition of DNA recombination at telomere
Drugs
Diseases
GWAS		Apolipoprotein A1 levels ( 32203549) HDL cholesterol levels ( 32203549)	A body shape index ( 34021172) Heel bone mineral density ( 30598549) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 26426971 34021172) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		16 interacting genes: ATF7IP EMX1 ESR1 HOXC9 IKBKG NR5A2 POLR2A POLR2B POLR2C POLR2E POLR2G POLR2H POLR2K POLR2L TRIM29 ZSCAN1	29 interacting genes: CBX6 CYSRT1 ELAVL2 GMNN GTF2A1L HOXC13 HOXD1 HOXD9 IRF9 KRTAP6-2 LPXN MAGED1 MSX2 NFKBID NMI PAX6 PAX8 PBX2 PCGF2 POLR2D POLR3D POU2AF1 POU2F1 SPMIP9 TLE5 UFSP1 ZFP36 ZMYND12 ZNF384
Entrez ID		5433	3225
HPRD ID		16191	00857
Ensembl ID		ENSG00000144231	ENSG00000180806
Uniprot IDs		O15514	P31274
PDB IDs		2C35 5IY6 5IY7 5IY8 5IY9 5IYA 5IYB 5IYC 5IYD 6DRD 6O9L 6XRE 7LBM 9EHZ 9EI1 9EI3 9EI4	2LP0 2MSY
Enriched GO Terms of Interacting Partners?		RNA Polymerase II, Core Complex DNA-directed RNA Polymerase Complex DNA-directed RNA Polymerase Activity DNA-templated Transcription Transcription By RNA Polymerase II RNA Polymerase I Complex Nucleobase-containing Compound Biosynthetic Process RNA Polymerase III Complex DNA Binding RNA Metabolic Process Macromolecule Biosynthetic Process Nucleoplasm Nucleic Acid Metabolic Process RNA-directed RNA Polymerase Activity RNA-templated Transcription Regulation Of RNA Metabolic Process Nucleus Transcription By RNA Polymerase III Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Zinc Ion Binding Nucleobase-containing Compound Metabolic Process 5'-3' RNA Polymerase Activity TRNA Transcription By RNA Polymerase III TRNA Transcription Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Nucleolus Sequence-specific Double-stranded DNA Binding Regulation Of Primary Metabolic Process Regulation Of Macromolecule Metabolic Process Ovulation Cycle Process Transcription Coregulator Binding Regulation Of Transcription By RNA Polymerase I Regulation Of Transcription By RNA Polymerase II Zygotic Genome Activation Nuclear Receptor Activity DNA-templated Transcription Elongation Regulation Of Metabolic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Positive Regulation Of Glucocorticoid Biosynthetic Process Positive Regulation Of Tendon Cell Differentiation Primary Ovarian Follicle Growth Metal Ion Binding Chromatin DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Prostate Epithelial Cord Elongation Positive Regulation Of Nitric-oxide Synthase Activity Morula Formation	Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Gene Expression Chromatin Regulation Of Macromolecule Biosynthetic Process Regulation Of RNA Metabolic Process DNA Binding Regionalization Regulation Of Transcription By RNA Polymerase II Regulation Of Nucleobase-containing Compound Metabolic Process Nucleus Regulation Of Macromolecule Metabolic Process Pattern Specification Process Sequence-specific Double-stranded DNA Binding DNA-templated Transcription Regulation Of Metabolic Process Regulation Of Primary Metabolic Process Anterior/posterior Pattern Specification DNA-binding Transcription Factor Activity Chromatin Binding Animal Organ Morphogenesis Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Negative Regulation Of RNA Metabolic Process Embryonic Morphogenesis Transcription Cis-regulatory Region Binding Positive Regulation Of RNA Metabolic Process Embryonic Skeletal System Development Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Epithelial Cell Differentiation Negative Regulation Of Transcription By RNA Polymerase II RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Positive Regulation Of Nucleobase-containing Compound Metabolic Process Skeletal System Development Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Embryonic Limb Morphogenesis PRC1 Complex Positive Regulation Of Branching Involved In Ureteric Bud Morphogenesis Nucleobase-containing Compound Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Macromolecule Biosynthetic Process RNA Polymerase II Core Promoter Sequence-specific DNA Binding Regulation Of Branching Involved In Ureteric Bud Morphogenesis Negative Regulation Of Biosynthetic Process Positive Regulation Of Biosynthetic Process Limb Morphogenesis Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Macromolecule Metabolic Process
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