POLR2D and POLR2L

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (pull down, two hybrid)
HPRD (in vitro)

		POLR2D	POLR2L
Gene Name		polymerase (RNA) II (DNA directed) polypeptide D	polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasmic MRNA Processing Body Nucleus Nucleoplasm DNA-directed RNA Polymerase II, Core Complex	Nucleus Nucleoplasm DNA-directed RNA Polymerase II, Core Complex DNA-directed RNA Polymerase III Complex DNA-directed RNA Polymerase I Complex Cytosol
	Molecular Function	Nucleotide Binding Single-stranded DNA Binding Single-stranded RNA Binding DNA-directed RNA Polymerase Activity Translation Initiation Factor Binding	RNA Polymerase I Activity RNA Polymerase II Activity RNA Polymerase III Activity DNA Binding DNA-directed RNA Polymerase Activity Zinc Ion Binding
	Biological Process	Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay MRNA Splicing, Via Spliceosome DNA Repair Transcription-coupled Nucleotide-excision Repair Nucleotide-excision Repair Transcription From RNA Polymerase II Promoter Transcription Initiation From RNA Polymerase II Promoter Transcription Elongation From RNA Polymerase II Promoter 7-methylguanosine MRNA Capping RNA Splicing Gene Expression Viral Process MRNA Export From Nucleus In Response To Heat Stress Recruitment Of 3'-end Processing Factors To RNA Polymerase II Holoenzyme Complex PiRNA Metabolic Process Somatic Stem Cell Maintenance Positive Regulation Of Translational Initiation Positive Regulation Of Viral Transcription	MRNA Splicing, Via Spliceosome DNA Repair Transcription-coupled Nucleotide-excision Repair Nucleotide-excision Repair Regulation Of Transcription From RNA Polymerase I Promoter Transcription From RNA Polymerase I Promoter Transcription Initiation From RNA Polymerase I Promoter Transcription Elongation From RNA Polymerase I Promoter Termination Of RNA Polymerase I Transcription Transcription From RNA Polymerase II Promoter Transcription Initiation From RNA Polymerase II Promoter Transcription Elongation From RNA Polymerase II Promoter 7-methylguanosine MRNA Capping Transcription From RNA Polymerase III Promoter Transcription Elongation From RNA Polymerase III Promoter Termination Of RNA Polymerase III Transcription RNA Splicing Gene Expression Viral Process Positive Regulation Of Type I Interferon Production PiRNA Metabolic Process Somatic Stem Cell Maintenance Regulation Of Gene Expression, Epigenetic Innate Immune Response Negative Regulation Of Gene Expression, Epigenetic Positive Regulation Of Viral Transcription
Pathways		RNA Polymerase II Promoter Escape mRNA Splicing Formation of HIV-1 elongation complex containing HIV-1 Tat PIWI-interacting RNA (piRNA) biogenesis Nucleotide Excision Repair RNA Polymerase II Transcription Pre-Initiation And Promoter Opening RNA Polymerase II Transcription Abortive elongation of HIV-1 transcript in the absence of Tat HIV Infection Regulatory RNA pathways Formation of the Early Elongation Complex Tat-mediated elongation of the HIV-1 transcript Tat-mediated HIV elongation arrest and recovery Formation of transcription-coupled NER (TC-NER) repair complex RNA Pol II CTD phosphorylation and interaction with CE RNA Polymerase II Pre-transcription Events Dual incision reaction in TC-NER Influenza Life Cycle HIV elongation arrest and recovery HIV Life Cycle HIV Transcription Initiation Influenza Viral RNA Transcription and Replication RNA Pol II CTD phosphorylation and interaction with CE Transcriptional regulation of pluripotent stem cells RNA Polymerase II HIV Promoter Escape HIV Transcription Elongation POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation Transcriptional regulation by small RNAs Processing of Capped Intron-Containing Pre-mRNA mRNA Capping mRNA Splicing - Minor Pathway mRNA Splicing - Major Pathway MicroRNA (miRNA) biogenesis Influenza Infection Pausing and recovery of Tat-mediated HIV elongation Late Phase of HIV Life Cycle Formation of RNA Pol II elongation complex RNA Polymerase II Transcription Initiation And Promoter Clearance Pausing and recovery of HIV elongation Formation of HIV elongation complex in the absence of HIV Tat Transcription-coupled NER (TC-NER) Viral Messenger RNA Synthesis Formation of the HIV-1 Early Elongation Complex RNA Polymerase II Transcription Initiation Transcription of the HIV genome RNA Polymerase II Transcription Elongation	RNA Polymerase II Promoter Escape Formation of HIV-1 elongation complex containing HIV-1 Tat RNA Polymerase II Transcription Pre-Initiation And Promoter Opening RNA Polymerase I Chain Elongation Abortive elongation of HIV-1 transcript in the absence of Tat RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription Regulatory RNA pathways Tat-mediated elongation of the HIV-1 transcript Tat-mediated HIV elongation arrest and recovery Formation of transcription-coupled NER (TC-NER) repair complex Dual incision reaction in TC-NER Influenza Life Cycle RNA Polymerase III Transcription Termination HIV elongation arrest and recovery NoRC negatively regulates rRNA expression Influenza Viral RNA Transcription and Replication RNA Polymerase III Chain Elongation RNA Polymerase III Transcription RNA Polymerase III Transcription Initiation From Type 1 Promoter mRNA Splicing - Minor Pathway mRNA Splicing - Major Pathway MicroRNA (miRNA) biogenesis Influenza Infection Pausing and recovery of Tat-mediated HIV elongation Late Phase of HIV Life Cycle RNA Polymerase III Transcription Initiation From Type 2 Promoter Formation of RNA Pol II elongation complex RNA Polymerase II Transcription Initiation And Promoter Clearance RNA Polymerase III Abortive And Retractive Initiation Transcription of the HIV genome Nucleotide Excision Repair PIWI-interacting RNA (piRNA) biogenesis mRNA Splicing RNA Polymerase III Transcription Initiation From Type 3 Promoter RNA Polymerase II Transcription RNA Polymerase I Transcription Initiation RNA Polymerase I Promoter Clearance HIV Infection Formation of the Early Elongation Complex RNA Pol II CTD phosphorylation and interaction with CE RNA Polymerase II Pre-transcription Events HIV Transcription Initiation HIV Life Cycle RNA Pol II CTD phosphorylation and interaction with CE Transcriptional regulation of pluripotent stem cells RNA Polymerase II HIV Promoter Escape HIV Transcription Elongation POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation Innate Immune System RNA Polymerase III Transcription Initiation Transcriptional regulation by small RNAs Processing of Capped Intron-Containing Pre-mRNA mRNA Capping RNA Polymerase I Transcription RNA Polymerase I Promoter Escape RNA Polymerase I Transcription Termination Cytosolic sensors of pathogen-associated DNA Epigenetic regulation of gene expression Negative epigenetic regulation of rRNA expression Transcription-coupled NER (TC-NER) Formation of HIV elongation complex in the absence of HIV Tat Pausing and recovery of HIV elongation Formation of the HIV-1 Early Elongation Complex Viral Messenger RNA Synthesis RNA Polymerase II Transcription Initiation RNA Polymerase II Transcription Elongation
Drugs
Diseases
GWAS
Protein-Protein Interactions		16 interactors: ATF7IP EMX1 ESR1 HOXC9 IKBKG NR5A2 POLR2A POLR2B POLR2C POLR2E POLR2G POLR2H POLR2K POLR2L TRIM29 ZSCAN1	23 interactors: BANP CCDC85B CHEK2 COIL EXOSC5 L3MBTL3 NFKBIB NOV PHC2 POLR2A POLR2B POLR2C POLR2D POLR2E POLR2G POLR2H REL RPAP1 SNX7 SPAG5 THAP1 TP53BP2 ZBTB14
Entrez ID		5433	5441
HPRD ID		16191	01155
Ensembl ID		ENSG00000144231	ENSG00000177700
Uniprot IDs		E9PB93 E9PHV4 O15514	P62875
PDB IDs		2C35
Enriched GO Terms of Interacting Partners?		7-methylguanosine MRNA Capping PiRNA Metabolic Process 7-methylguanosine RNA Capping Positive Regulation Of Viral Process Transcription-coupled Nucleotide-excision Repair Positive Regulation Of Viral Transcription Transcription Initiation From RNA Polymerase II Promoter Transcription Elongation From RNA Polymerase II Promoter DNA-templated Transcription, Initiation Somatic Stem Cell Maintenance Regulation Of Viral Transcription Regulation Of Viral Process DNA-templated Transcription, Elongation Nucleotide-excision Repair Transcription From RNA Polymerase II Promoter Transcription, DNA-templated RNA Biosynthetic Process Stem Cell Maintenance Viral Process MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions RNA Metabolic Process Stem Cell Development Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Gene Expression Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Cellular Macromolecule Biosynthetic Process Stem Cell Differentiation Macromolecule Biosynthetic Process Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process RNA Splicing MRNA Processing Termination Of RNA Polymerase III Transcription Transcription Elongation From RNA Polymerase III Promoter Nucleobase-containing Compound Metabolic Process NcRNA Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process MRNA Metabolic Process Cellular Response To DNA Damage Stimulus Cellular Nitrogen Compound Metabolic Process RNA Processing Positive Regulation Of Type I Interferon Production DNA Repair Termination Of RNA Polymerase I Transcription	7-methylguanosine MRNA Capping PiRNA Metabolic Process 7-methylguanosine RNA Capping Transcription-coupled Nucleotide-excision Repair Positive Regulation Of Viral Transcription Transcription Elongation From RNA Polymerase II Promoter Somatic Stem Cell Maintenance Regulation Of Viral Transcription Positive Regulation Of Viral Process DNA-templated Transcription, Elongation Nucleotide-excision Repair Transcription, DNA-templated RNA Biosynthetic Process RNA Metabolic Process Stem Cell Maintenance Regulation Of Viral Process Gene Expression Transcription Initiation From RNA Polymerase II Promoter DNA-templated Transcription, Initiation MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Stem Cell Development Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process NcRNA Metabolic Process Nucleobase-containing Compound Metabolic Process Stem Cell Differentiation Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process MRNA Metabolic Process RNA Splicing Cellular Nitrogen Compound Metabolic Process DNA Repair Transcription From RNA Polymerase II Promoter MRNA Processing Nitrogen Compound Metabolic Process Biosynthetic Process Negative Regulation Of Cell Differentiation DNA Metabolic Process Regulation Of Gene Expression Regulation Of RNA Biosynthetic Process Viral Process Cellular Response To DNA Damage Stimulus Regulation Of RNA Metabolic Process RNA Processing Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Cell Development
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