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POLR2D and POLR2B
Number of citations of the paper that reports this interaction (PubMedID
35271311
)
106
Data Source:
BioGRID
(affinity chromatography technology)
HPRD
(in vitro)
POLR2D
POLR2B
Description
RNA polymerase II subunit D
RNA polymerase II subunit B
Image
GO Annotations
Cellular Component
DNA-directed RNA Polymerase Complex
Nucleus
Nucleoplasm
RNA Polymerase II, Core Complex
Cytosol
Nuclear Speck
RNA Polymerase Complex
DNA-directed RNA Polymerase Complex
Chromosome, Telomeric Region
Nucleus
Nucleoplasm
RNA Polymerase II, Core Complex
Membrane
Molecular Function
Nucleotide Binding
Protein Binding
Translation Initiation Factor Binding
DNA Binding
Chromatin Binding
RNA Binding
DNA-directed RNA Polymerase Activity
RNA-directed RNA Polymerase Activity
Protein Binding
Zinc Ion Binding
Transferase Activity
Nucleotidyltransferase Activity
Hydrolase Activity
Ribonucleoside Binding
5'-3' RNA Polymerase Activity
Metal Ion Binding
Biological Process
DNA-templated Transcription Initiation
Transcription By RNA Polymerase II
Transcription Initiation At RNA Polymerase II Promoter
RNA-templated Transcription
DNA-templated Transcription
Transcription By RNA Polymerase II
Pathways
Formation of RNA Pol II elongation complex
Formation of the Early Elongation Complex
Formation of HIV elongation complex in the absence of HIV Tat
Formation of the HIV-1 Early Elongation Complex
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection
HIV Transcription Initiation
RNA Polymerase II HIV Promoter Escape
Transcription of the HIV genome
Formation of HIV-1 elongation complex containing HIV-1 Tat
Formation of HIV-1 elongation complex containing HIV-1 Tat
Pausing and recovery of Tat-mediated HIV elongation
Abortive elongation of HIV-1 transcript in the absence of Tat
Tat-mediated HIV elongation arrest and recovery
Tat-mediated elongation of the HIV-1 transcript
HIV elongation arrest and recovery
Pausing and recovery of HIV elongation
Viral Messenger RNA Synthesis
MicroRNA (miRNA) biogenesis
Transcriptional regulation by small RNAs
PIWI-interacting RNA (piRNA) biogenesis
Activation of anterior HOX genes in hindbrain development during early embryogenesis
RNA Polymerase II Pre-transcription Events
Formation of TC-NER Pre-Incision Complex
Transcription-Coupled Nucleotide Excision Repair (TC-NER)
Dual incision in TC-NER
Gap-filling DNA repair synthesis and ligation in TC-NER
TP53 Regulates Transcription of DNA Repair Genes
FGFR2 alternative splicing
RNA polymerase II transcribes snRNA genes
RNA polymerase II transcribes snRNA genes
mRNA Capping
mRNA Splicing - Major Pathway
mRNA Splicing - Minor Pathway
Processing of Capped Intron-Containing Pre-mRNA
RNA Polymerase II Promoter Escape
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
RNA Polymerase II Transcription Initiation
RNA Polymerase II Transcription Elongation
RNA Polymerase II Transcription Initiation And Promoter Clearance
RNA Pol II CTD phosphorylation and interaction with CE
Signaling by FGFR2 IIIa TM
Estrogen-dependent gene expression
Inhibition of DNA recombination at telomere
Formation of RNA Pol II elongation complex
Formation of the Early Elongation Complex
Formation of HIV elongation complex in the absence of HIV Tat
Formation of the HIV-1 Early Elongation Complex
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection
HIV Transcription Initiation
RNA Polymerase II HIV Promoter Escape
Transcription of the HIV genome
Formation of HIV-1 elongation complex containing HIV-1 Tat
Formation of HIV-1 elongation complex containing HIV-1 Tat
Pausing and recovery of Tat-mediated HIV elongation
Abortive elongation of HIV-1 transcript in the absence of Tat
Tat-mediated HIV elongation arrest and recovery
Tat-mediated elongation of the HIV-1 transcript
HIV elongation arrest and recovery
Pausing and recovery of HIV elongation
Viral Messenger RNA Synthesis
MicroRNA (miRNA) biogenesis
Transcriptional regulation by small RNAs
PIWI-interacting RNA (piRNA) biogenesis
Activation of anterior HOX genes in hindbrain development during early embryogenesis
RNA Polymerase II Pre-transcription Events
Formation of TC-NER Pre-Incision Complex
Transcription-Coupled Nucleotide Excision Repair (TC-NER)
Dual incision in TC-NER
Gap-filling DNA repair synthesis and ligation in TC-NER
TP53 Regulates Transcription of DNA Repair Genes
FGFR2 alternative splicing
RNA polymerase II transcribes snRNA genes
RNA polymerase II transcribes snRNA genes
mRNA Capping
mRNA Splicing - Major Pathway
mRNA Splicing - Minor Pathway
Processing of Capped Intron-Containing Pre-mRNA
RNA Polymerase II Promoter Escape
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
RNA Polymerase II Transcription Initiation
RNA Polymerase II Transcription Elongation
RNA Polymerase II Transcription Initiation And Promoter Clearance
RNA Pol II CTD phosphorylation and interaction with CE
Signaling by FGFR2 IIIa TM
Estrogen-dependent gene expression
Inhibition of DNA recombination at telomere
Drugs
Diseases
GWAS
Apolipoprotein A1 levels (
32203549
)
HDL cholesterol levels (
32203549
)
Age-related macular degeneration (
21909106
)
Bitter alcoholic beverage consumption (
31046077
)
Congenital heart disease (maternal effect) (
28468790
)
Coronary artery disease (
29212778
)
Height (
20881960
25429064
)
Metabolite levels (
23823483
)
White blood cell count (
29403010
)
Interacting Genes
16 interacting genes:
ATF7IP
EMX1
ESR1
HOXC9
IKBKG
NR5A2
POLR2A
POLR2B
POLR2C
POLR2E
POLR2G
POLR2H
POLR2K
POLR2L
TRIM29
ZSCAN1
19 interacting genes:
BTF3
CALM1
CCNH
CDK7
CTDP1
IKBKG
ITCH
LZTR1
MEN1
OTUD5
POLR2C
POLR2D
POLR2H
POLR2L
PTEN
RPAP1
SNAR-B2
SUB1
ZSCAN1
Entrez ID
5433
5431
HPRD ID
16191
15943
Ensembl ID
ENSG00000144231
ENSG00000047315
Uniprot IDs
O15514
B4DH29
B4DHJ3
C9J2Y9
P30876
PDB IDs
2C35
5IY6
5IY7
5IY8
5IY9
5IYA
5IYB
5IYC
5IYD
6DRD
6O9L
6XRE
7LBM
9EHZ
9EI1
9EI3
9EI4
5IY6
5IY7
5IY8
5IY9
5IYA
5IYB
5IYC
5IYD
6DRD
6O9L
6XRE
7LBM
9EHZ
9EI1
9EI3
9EI4
Enriched GO Terms of Interacting Partners
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RNA Polymerase II, Core Complex
DNA-directed RNA Polymerase Complex
DNA-directed RNA Polymerase Activity
DNA-templated Transcription
Transcription By RNA Polymerase II
RNA Polymerase I Complex
Nucleobase-containing Compound Biosynthetic Process
RNA Polymerase III Complex
DNA Binding
RNA Metabolic Process
Macromolecule Biosynthetic Process
Nucleoplasm
Nucleic Acid Metabolic Process
RNA-directed RNA Polymerase Activity
RNA-templated Transcription
Regulation Of RNA Metabolic Process
Nucleus
Transcription By RNA Polymerase III
Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of DNA-templated Transcription
Regulation Of RNA Biosynthetic Process
Zinc Ion Binding
Nucleobase-containing Compound Metabolic Process
5'-3' RNA Polymerase Activity
TRNA Transcription By RNA Polymerase III
TRNA Transcription
Regulation Of Gene Expression
Regulation Of Macromolecule Biosynthetic Process
Nucleolus
Sequence-specific Double-stranded DNA Binding
Regulation Of Primary Metabolic Process
Regulation Of Macromolecule Metabolic Process
Ovulation Cycle Process
Transcription Coregulator Binding
Regulation Of Transcription By RNA Polymerase I
Regulation Of Transcription By RNA Polymerase II
Zygotic Genome Activation
Nuclear Receptor Activity
DNA-templated Transcription Elongation
Regulation Of Metabolic Process
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
Positive Regulation Of Glucocorticoid Biosynthetic Process
Positive Regulation Of Tendon Cell Differentiation
Primary Ovarian Follicle Growth
Metal Ion Binding
Chromatin
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
Prostate Epithelial Cord Elongation
Positive Regulation Of Nitric-oxide Synthase Activity
Morula Formation
DNA-directed RNA Polymerase Complex
RNA Polymerase II, Core Complex
Nucleobase-containing Compound Biosynthetic Process
Nucleus
DNA-templated Transcription
Transcription By RNA Polymerase II
Transcription Factor TFIIK Complex
DNA-directed RNA Polymerase Activity
CAK-ERCC2 Complex
RNA Metabolic Process
Macromolecule Biosynthetic Process
Nucleic Acid Metabolic Process
Transcription Initiation At RNA Polymerase II Promoter
Nucleoplasm
RNA Polymerase II Promoter Clearance
Macromolecule Metabolic Process
Transcription Factor TFIIH Core Complex
DNA-templated Transcription Initiation
Transcription Factor TFIIH Holo Complex
RNA Polymerase I Complex
Nucleobase-containing Compound Metabolic Process
RNA Polymerase III Complex
Spindle Pole
Regulation Of G1/S Transition Of Mitotic Cell Cycle
Negative Regulation Of JNK Cascade
Negative Regulation Of Organ Growth
Protein-containing Complex
Regulation Of Cell Cycle G1/S Phase Transition
Cyclin-dependent Protein Kinase Holoenzyme Complex
Transcription Elongation By RNA Polymerase II
RNA Polymerase II CTD Heptapeptide Repeat S5 Kinase Activity
Negative Regulation Of Intracellular Signal Transduction
Negative Regulation Of Synaptic Vesicle Clustering
Negative Regulation Of Type I Interferon Production
Male Germ Cell Nucleus
DNA-templated Transcription Elongation
Negative Regulation Of Protein Localization To Endoplasmic Reticulum
Negative Regulation Of High Voltage-gated Calcium Channel Activity
Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity
Protein Stabilization
CD4-positive, Alpha-beta T Cell Activation
RNA Polymerase Complex
Phosphatidylinositol-3,4-bisphosphate 3-phosphatase Activity
Negative Regulation Of Keratinocyte Migration
Inositol-1,3,4,5-tetrakisphosphate 3-phosphatase Activity
Inositol-1,3,4,5,6-pentakisphosphate 3-phosphatase Activity
TFIIF-class Transcription Factor Complex Binding
Negative Regulation Of Osteoblast Differentiation
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Tagcloud (Difference)
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Tagcloud (Intersection)
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