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KCNAB2 and NEDD4L
Number of citations of the paper that reports this interaction (PMID
19953087
)
25
Data Source:
BioGRID
(pull down)
KCNAB2
NEDD4L
Gene Name
potassium channel, voltage gated subfamily A regulatory beta subunit 2
neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
Image
Gene Ontology Annotations
Cellular Component
Cytosol
Microtubule
Plasma Membrane
Voltage-gated Potassium Channel Complex
Membrane
Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane
Juxtaparanode Region Of Axon
Pinceau Fiber
Intracellular
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Plasma Membrane
Extracellular Vesicular Exosome
Molecular Function
Aldo-keto Reductase (NADP) Activity
Voltage-gated Potassium Channel Activity
Potassium Channel Regulator Activity
Ubiquitin-protein Transferase Activity
Protein Binding
Potassium Channel Regulator Activity
Ligase Activity
Sodium Channel Regulator Activity
Potassium Channel Inhibitor Activity
Sodium Channel Inhibitor Activity
Ion Channel Binding
Biological Process
Hematopoietic Progenitor Cell Differentiation
Synaptic Transmission
Protein Heterooligomerization
Oxidation-reduction Process
NADPH Oxidation
Potassium Ion Transmembrane Transport
Regulation Of Potassium Ion Transmembrane Transport
Regulation Of Protein Localization To Cell Surface
Negative Regulation Of Transcription From RNA Polymerase II Promoter
Negative Regulation Of Systemic Arterial Blood Pressure
Regulation Of Membrane Depolarization
Transcription, DNA-templated
Transcription Initiation From RNA Polymerase II Promoter
Protein Monoubiquitination
Sodium Ion Transport
Cellular Sodium Ion Homeostasis
Transforming Growth Factor Beta Receptor Signaling Pathway
Excretion
Response To Salt Stress
Response To Metal Ion
Gene Expression
Positive Regulation Of Sodium Ion Transport
Viral Process
Protein Ubiquitination
Viral Life Cycle
Water Homeostasis
Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Ion Transmembrane Transport
Regulation Of Ion Transmembrane Transport
Regulation Of Protein Catabolic Process
Regulation Of Membrane Potential
Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway
Positive Regulation Of Protein Catabolic Process
Positive Regulation Of Endocytosis
Transmembrane Transport
Regulation Of Membrane Repolarization
Protein K48-linked Ubiquitination
Ventricular Cardiac Muscle Cell Action Potential
Regulation Of Potassium Ion Transmembrane Transporter Activity
Negative Regulation Of Potassium Ion Transmembrane Transporter Activity
Negative Regulation Of Potassium Ion Transmembrane Transport
Negative Regulation Of Sodium Ion Transmembrane Transport
Negative Regulation Of Protein Localization To Cell Surface
Negative Regulation Of Sodium Ion Transmembrane Transporter Activity
Regulation Of Tight Junction Assembly
Positive Regulation Of Cation Channel Activity
Positive Regulation Of Caveolin-mediated Endocytosis
Pathways
Potassium Channels
Voltage gated Potassium channels
Loss of Function of TGFBR2 in Cancer
Antigen processing: Ubiquitination & Proteasome degradation
HIV Infection
SMAD2/3 MH2 Domain Mutants in Cancer
Downregulation of TGF-beta receptor signaling
TGF-beta receptor signaling activates SMADs
TGFBR1 LBD Mutants in Cancer
Downregulation of SMAD2/3:SMAD4 transcriptional activity
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer
HIV Life Cycle
Budding and maturation of HIV virion
Ion channel transport
Generic Transcription Pathway
Stimuli-sensing channels
Class I MHC mediated antigen processing & presentation
TGFBR2 MSI Frameshift Mutants in Cancer
SMAD2/3 Phosphorylation Motif Mutants in Cancer
Loss of Function of SMAD2/3 in Cancer
TGFBR2 Kinase Domain Mutants in Cancer
Loss of Function of SMAD4 in Cancer
TGFBR1 KD Mutants in Cancer
Late Phase of HIV Life Cycle
Loss of Function of TGFBR1 in Cancer
Signaling by TGF-beta Receptor Complex in Cancer
Signaling by TGF-beta Receptor Complex
SMAD4 MH2 Domain Mutants in Cancer
Adaptive Immune System
Drugs
Diseases
GWAS
Insomnia (caffeine-induced) (
22754043
)
Liver enzyme levels (gamma-glutamyl transferase) (
22001757
)
Response to amphetamines (
22952603
)
Protein-Protein Interactions
8 interactors:
ATXN1
CD4
KCNA2
NEDD4
NEDD4L
SLC39A1
SLC39A2
SQSTM1
126 interactors:
AATF
ABL1
ABL2
ACVR1B
ACY3
ADAP2
AICDA
AKT3
APEX2
ARHGDIA
AURKC
BBX
BMPR1A
BRAF
C7orf50
CACNB1
CAMK1D
CDC34
CDK3
CDK5
CLIC2
CUEDC1
CYBRD1
CYP26B1
DAPK3
DAZAP2
DDX54
DECR2
DMTN
DYRK3
EFEMP2
FGF12
FKBP3
GORAB
H1F0
HAX1
HGS
IFRD2
IKBKB
KCNAB1
KCNAB2
KCNAB3
KCNB1
KIF3B
KIFC3
LAPTM5
MAGEB1
MAP2
MAP3K2
MAP3K3
MAP3K5
MAPKAPK3
MARK2
MERTK
MINK1
MOB3A
MRPL19
NDFIP2
NHP2
NR3C1
NSRP1
NTRK1
NUDT16L1
PBX1
PRKX
PRR16
PRRG1
PSMD4
RANBP10
RASL10B
RASL11B
RNF11
RNF7
ROBO3
RPL30
RPS6KB2
SCAMP3
SCD
SCN5A
SCNN1A
SCNN1B
SCNN1G
SENP2
SERPINF1
SGK1
SGK2
SIVA1
SLC7A7
SMAD2
SMAD3
SMAD7
SNCA
SPAG8
SRMS
STAC
STK40
TAF1B
TARBP2
TBC1D7
TCEAL2
TGFB1I1
TMA16
TMEM55A
TRIM41
UBAC1
UBC
UBE2D1
UBE2D2
UBE2D3
UBE2E1
UBE2E3
UBE2J2
UBE2K
UBE2L3
UBE2N
VDAC2
WIBG
WNK1
WNK4
YWHAG
YWHAZ
YY1
ZADH2
ZAK
ZC3HAV1L
ZDHHC3
Entrez ID
8514
23327
HPRD ID
03090
05903
Ensembl ID
ENSG00000069424
ENSG00000049759
Uniprot IDs
B2R776
Q13303
Q2YD85
B7Z2P9
B7Z6K0
F5H602
Q96PU5
PDB IDs
1ZSX
2LAJ
2LB2
2LTY
2NSQ
2ONI
3JVZ
3JW0
Enriched GO Terms of Interacting Partners
?
Regulation Of Membrane Potential
Negative Regulation Of Sodium Ion Transport
Zinc Ion Transmembrane Transport
Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway
Regulation Of Potassium Ion Transmembrane Transporter Activity
Zinc Ion Transport
Regulation Of Potassium Ion Transmembrane Transport
Protein Monoubiquitination
Metal Ion Transport
Transport
Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process
Regulation Of Potassium Ion Transport
Regulation Of Sodium Ion Transport
Regulation Of Ion Transmembrane Transport
Negative Regulation Of Transcription From RNA Polymerase II Promoter In Response To UV-induced DNA Damage
Induction By Virus Of Host Cell-cell Fusion
Transmission Of Virus
Protein Palmitoleylation
Development Involved In Symbiotic Interaction
Action Potential
Cation Transport
Positive Regulation Of Protein Metabolic Process
Negative Regulation Of Ion Transport
Ubiquitin-dependent Protein Catabolic Process
Modification-dependent Protein Catabolic Process
Interaction With Host
Ion Transmembrane Transport
Negative Regulation Of Cellular Response To Growth Factor Stimulus
Viral Process
Proteolysis Involved In Cellular Protein Catabolic Process
Optic Nerve Structural Organization
Positive Regulation Of Caveolin-mediated Endocytosis
Cellular Protein Catabolic Process
Protein Catabolic Process
Regulation Of Signal Transduction
Regulation Of Ion Transport
Regulation Of Ion Transmembrane Transporter Activity
Regulation Of Transmembrane Transporter Activity
Protein Polyubiquitination
Regulation Of Signaling
Transmembrane Transport
Regulation Of Cellular Response To Growth Factor Stimulus
Ion Transport
Negative Regulation Of Transcription From RNA Polymerase II Promoter
Regulation Of Caveolin-mediated Endocytosis
Progesterone Receptor Signaling Pathway
Negative Regulation Of Sodium Ion Transmembrane Transporter Activity
Regulation Of Transcription From RNA Polymerase II Promoter
Regulation Of Transcription From RNA Polymerase II Promoter In Response To UV-induced DNA Damage
Negative Regulation Of Sodium Ion Transmembrane Transport
Cellular Protein Modification Process
Protein Phosphorylation
Intracellular Signal Transduction
Response To Stimulus
Phosphorylation
Positive Regulation Of Cellular Protein Metabolic Process
Cellular Protein Metabolic Process
Positive Regulation Of Protein Metabolic Process
Regulation Of Protein Metabolic Process
Regulation Of Cellular Protein Metabolic Process
Positive Regulation Of Protein Modification Process
Signaling
Regulation Of Signal Transduction
Cell Communication
Regulation Of Signaling
Positive Regulation Of Metabolic Process
Protein Polyubiquitination
Response To Organic Substance
Cellular Response To Stimulus
Positive Regulation Of Cellular Metabolic Process
Positive Regulation Of Signal Transduction
Response To Growth Factor
Cellular Response To Organic Substance
Protein K48-linked Ubiquitination
Regulation Of Cellular Component Organization
Enzyme Linked Receptor Protein Signaling Pathway
Protein Metabolic Process
Regulation Of Phosphorylation
Regulation Of Cell Death
Regulation Of Apoptotic Process
Regulation Of Protein Ubiquitination
Protein Modification By Small Protein Conjugation
Regulation Of Protein Phosphorylation
Protein Autophosphorylation
Phosphate-containing Compound Metabolic Process
Signal Transduction
Positive Regulation Of Transferase Activity
Regulation Of Ubiquitin-protein Transferase Activity
Positive Regulation Of Transport
Cellular Response To Growth Factor Stimulus
Cellular Metabolic Process
Immune System Process
Protein Ubiquitination
Regulation Of Cellular Process
Positive Regulation Of Protein Ubiquitination
Cell Death
Positive Regulation Of Programmed Cell Death
Regulation Of Phosphorus Metabolic Process
Death
Regulation Of Cellular Component Movement
Tagcloud
?
2cl
antihypertensive
cotransporter
defective
demonstrating
emerging
enac
exchanger
highlight
hypertension
interactor
interesting
liddle
ligase
makes
na
ncc
nephron
nhe3
nkcc2
originally
progress
salt
sensitive
thiazide
transporters
ubiquitin
ubiquitylates
Tagcloud (Difference)
?
2cl
antihypertensive
cotransporter
defective
demonstrating
emerging
enac
exchanger
highlight
hypertension
interactor
interesting
liddle
ligase
makes
na
ncc
nephron
nhe3
nkcc2
originally
progress
salt
sensitive
thiazide
transporters
ubiquitin
ubiquitylates
Tagcloud (Intersection)
?