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KCNAB2 and CD4
Number of citations of the paper that reports this interaction (PMID
12893943
)
48
Data Source:
HPRD
(in vitro)
KCNAB2
CD4
Gene Name
potassium channel, voltage gated subfamily A regulatory beta subunit 2
CD4 molecule
Image
Gene Ontology Annotations
Cellular Component
Cytosol
Microtubule
Plasma Membrane
Voltage-gated Potassium Channel Complex
Membrane
Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane
Juxtaparanode Region Of Axon
Pinceau Fiber
Early Endosome
Endoplasmic Reticulum Lumen
Endoplasmic Reticulum Membrane
Plasma Membrane
External Side Of Plasma Membrane
Integral Component Of Membrane
T Cell Receptor Complex
Membrane Raft
Molecular Function
Aldo-keto Reductase (NADP) Activity
Voltage-gated Potassium Channel Activity
Potassium Channel Regulator Activity
Glycoprotein Binding
Receptor Activity
Transmembrane Signaling Receptor Activity
Extracellular Matrix Structural Constituent
Protein Binding
Zinc Ion Binding
Coreceptor Activity
Enzyme Binding
Protein Kinase Binding
MHC Class II Protein Binding
Protein Homodimerization Activity
Biological Process
Hematopoietic Progenitor Cell Differentiation
Synaptic Transmission
Protein Heterooligomerization
Oxidation-reduction Process
NADPH Oxidation
Potassium Ion Transmembrane Transport
Regulation Of Potassium Ion Transmembrane Transport
Regulation Of Protein Localization To Cell Surface
Cytokine Production
Induction By Virus Of Host Cell-cell Fusion
Immune Response
Signal Transduction
Cell Surface Receptor Signaling Pathway
Enzyme Linked Receptor Protein Signaling Pathway
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Viral Process
T Cell Differentiation
Entry Into Host Cell
T Cell Costimulation
Maintenance Of Protein Location In Cell
T Cell Selection
Positive Regulation Of Interleukin-2 Biosynthetic Process
Innate Immune Response
Protein Palmitoleylation
Positive Regulation Of Protein Kinase Activity
Regulation Of Defense Response To Virus By Virus
Positive Regulation Of Peptidyl-tyrosine Phosphorylation
Defense Response To Gram-negative Bacterium
Positive Regulation Of Calcium-mediated Signaling
T Cell Receptor Signaling Pathway
Regulation Of T Cell Activation
Pathways
Potassium Channels
Voltage gated Potassium channels
Vpu mediated degradation of CD4
Downstream TCR signaling
Generation of second messenger molecules
Translocation of ZAP-70 to Immunological synapse
Costimulation by the CD28 family
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters
HIV Infection
Host Interactions of HIV factors
The role of Nef in HIV-1 replication and disease pathogenesis
Early Phase of HIV Life Cycle
HIV Life Cycle
TCR signaling
Alpha-defensins
PD-1 signaling
Defensins
Phosphorylation of CD3 and TCR zeta chains
Nef Mediated CD4 Down-regulation
Binding and entry of HIV virion
Innate Immune System
Adaptive Immune System
Drugs
Diseases
GWAS
Response to Vitamin E supplementation (
22437554
)
Protein-Protein Interactions
8 interactors:
ATXN1
CD4
KCNA2
NEDD4
NEDD4L
SLC39A1
SLC39A2
SQSTM1
38 interactors:
ABCB1
ADRB2
CCR5
CD2
CD28
CD38
CD44
CD5
CD53
CD82
CTSD
CXCL12
CXCR4
DPP4
FCGR3A
HLA-DPA1
HLA-DQA2
HLA-DQB1
IL16
IL2RA
INPPL1
KCNAB2
LAT
LCK
LGALS1
MAPK14
MARCH4
PI4KA
PIK3R1
PIP
PTPRC
SELL
SIVA1
SPG21
TFRC
TNFRSF10A
UBL7
UNC119
Entrez ID
8514
920
HPRD ID
03090
01740
Ensembl ID
ENSG00000069424
ENSG00000010610
Uniprot IDs
B2R776
Q13303
Q2YD85
B0AZV7
B4DT49
P01730
PDB IDs
1ZSX
1CDH
1CDI
1CDJ
1CDU
1CDY
1G9M
1G9N
1GC1
1JL4
1OPN
1OPT
1OPW
1Q68
1RZJ
1RZK
1WBR
1WIO
1WIP
1WIQ
2B4C
2JKR
2JKT
2KLU
2NXY
2NXZ
2NY0
2NY1
2NY2
2NY3
2NY4
2NY5
2NY6
2QAD
3B71
3CD4
3JWD
3JWO
3LQA
3O2D
3S4S
3S5L
3T0E
4JM2
Enriched GO Terms of Interacting Partners
?
Regulation Of Membrane Potential
Negative Regulation Of Sodium Ion Transport
Zinc Ion Transmembrane Transport
Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway
Regulation Of Potassium Ion Transmembrane Transporter Activity
Zinc Ion Transport
Regulation Of Potassium Ion Transmembrane Transport
Protein Monoubiquitination
Metal Ion Transport
Transport
Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process
Regulation Of Potassium Ion Transport
Regulation Of Sodium Ion Transport
Regulation Of Ion Transmembrane Transport
Negative Regulation Of Transcription From RNA Polymerase II Promoter In Response To UV-induced DNA Damage
Induction By Virus Of Host Cell-cell Fusion
Transmission Of Virus
Protein Palmitoleylation
Development Involved In Symbiotic Interaction
Action Potential
Cation Transport
Positive Regulation Of Protein Metabolic Process
Negative Regulation Of Ion Transport
Ubiquitin-dependent Protein Catabolic Process
Modification-dependent Protein Catabolic Process
Interaction With Host
Ion Transmembrane Transport
Negative Regulation Of Cellular Response To Growth Factor Stimulus
Viral Process
Proteolysis Involved In Cellular Protein Catabolic Process
Optic Nerve Structural Organization
Positive Regulation Of Caveolin-mediated Endocytosis
Cellular Protein Catabolic Process
Protein Catabolic Process
Regulation Of Signal Transduction
Regulation Of Ion Transport
Regulation Of Ion Transmembrane Transporter Activity
Regulation Of Transmembrane Transporter Activity
Protein Polyubiquitination
Regulation Of Signaling
Transmembrane Transport
Regulation Of Cellular Response To Growth Factor Stimulus
Ion Transport
Negative Regulation Of Transcription From RNA Polymerase II Promoter
Regulation Of Caveolin-mediated Endocytosis
Progesterone Receptor Signaling Pathway
Negative Regulation Of Sodium Ion Transmembrane Transporter Activity
Regulation Of Transcription From RNA Polymerase II Promoter
Regulation Of Transcription From RNA Polymerase II Promoter In Response To UV-induced DNA Damage
Negative Regulation Of Sodium Ion Transmembrane Transport
Immune System Process
Regulation Of Cell-cell Adhesion
Positive Regulation Of Immune System Process
Regulation Of Immune System Process
Regulation Of T Cell Activation
Regulation Of Lymphocyte Activation
Positive Regulation Of Homotypic Cell-cell Adhesion
Positive Regulation Of Cell Activation
Positive Regulation Of Cell-cell Adhesion
T Cell Costimulation
Regulation Of Cell Activation
Positive Regulation Of Cell Adhesion
Regulation Of Cell Adhesion
Antigen Receptor-mediated Signaling Pathway
Positive Regulation Of T Cell Activation
Immune Response-activating Cell Surface Receptor Signaling Pathway
Response To Stimulus
Immune Response-regulating Signaling Pathway
T Cell Receptor Signaling Pathway
Immune Response-regulating Cell Surface Receptor Signaling Pathway
Regulation Of Immune Response
Positive Regulation Of Immune Response
Signaling
Immune Response
Cell Communication
Signal Transduction
Cell Surface Receptor Signaling Pathway
Lymphocyte Activation
Leukocyte Aggregation
Cellular Response To Stimulus
Apoptotic Process
Leukocyte Cell-cell Adhesion
Homotypic Cell-cell Adhesion
Programmed Cell Death
Response To Stress
Leukocyte Migration
Leukocyte Activation
Cell Death
Death
Cell Activation
Defense Response
Homeostatic Process
T Cell Aggregation
T Cell Activation
Lymphocyte Aggregation
Locomotion
Cell Migration
Cell Motility
Single Organismal Cell-cell Adhesion
Cellular Chemical Homeostasis
Tagcloud
?
allergen
asthmatics
box
caat
cd18
chemotactic
coactivator
complexity
concert
consists
dyad
exons
ga
gabp
gabpalpha
harbor
inducible
introns
lymphocytes
mast
motifs
posttranslational
pro
processed
remote
share
supplementing
symmetry
tata
tightly
Tagcloud (Difference)
?
allergen
asthmatics
box
caat
cd18
chemotactic
coactivator
complexity
concert
consists
dyad
exons
ga
gabp
gabpalpha
harbor
inducible
introns
lymphocytes
mast
motifs
posttranslational
pro
processed
remote
share
supplementing
symmetry
tata
tightly
Tagcloud (Intersection)
?