SPAG5 and ZMAT2

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		SPAG5	ZMAT2
Description		sperm associated antigen 5	zinc finger matrin-type 2
Image		No pdb structure
GO Annotations	Cellular Component	Chromosome, Centromeric Region Kinetochore Spindle Pole Chromosome Cytoplasm Centrosome Spindle Cytosol Cytoskeleton Microtubule Nuclear Body Midbody Centriolar Satellite Ciliary Rootlet Microtubule Plus-end Ciliary Basal Body Mitotic Spindle Mitotic Spindle Pole	Nucleus Nucleoplasm Spliceosomal Complex U4/U6 X U5 Tri-snRNP Complex U2-type Precatalytic Spliceosome
	Molecular Function	Protein Binding Microtubule Binding	Nucleic Acid Binding DNA Binding Protein Binding Zinc Ion Binding Metal Ion Binding
	Biological Process	Mitotic Sister Chromatid Segregation Spindle Organization Chromosome Segregation Positive Regulation Of Intracellular Transport Establishment Of Spindle Orientation Cell Division Regulation Of Attachment Of Spindle Microtubules To Kinetochore Protein Localization To Centrosome Regulation Of Metaphase Plate Congression Positive Regulation Of Spindle Assembly	MRNA Splicing, Via Spliceosome MRNA Processing RNA Splicing
Pathways			mRNA Splicing - Major Pathway
Drugs
Diseases
GWAS			Major depressive disorder ( 27479909) Refractive error ( 32231278) Schizophrenia ( 28991256 29483656) Serum immune biomarker levels ( 32066700) Systolic blood pressure ( 30224653)
Interacting Genes		59 interacting genes: AIRIM AMOTL2 ARNT2 ATN1 BARD1 CCDC33 CCHCR1 CDC20B CDK1 CENPH CHCHD3 DCLRE1B DCX EIF4E2 EIF4ENIF1 ENKD1 FBXO28 FMR1 GEM GOLGA8EP GOLGA8F HAUS1 IGFN1 IQCE KANSL1 KRT3 KRT75 LGALS14 LINGO1 MID1 MID2 NEBL NLGN3 ODF1 ORC6 PIMREG PKN1 PLK4 POLR2L POM121 RBM41 SH2D4A SHANK3 SMARCA2 SMARCE1 SNAP47 SNAPIN SPAG5-AS1 TSC1 TSHZ3 TTC23 ZC2HC1C ZFC3H1 ZFYVE26 ZGPAT ZMAT2 ZNF385C ZNF572 ZNF688	41 interacting genes: AK8 AMH BICD2 CALCOCO1 CBY2 CCDC57 CDR2 CEBPA CEP76 ERBB2 FSD2 FXR1 FXR2 GOLGA2 GOLGA6L9 GRIPAP1 HAP1 HMBOX1 IKZF1 KANK2 KRT40 LZTS2 MEOX2 MTUS2 NAB2 NUTF2 PHC2 PICK1 PRPH SPAG5 SSX2IP TFEC TFIP11 TNIP1 TRAF2 TRIM36 TRIM37 TSEN15 VPS52 ZBTB14 ZBTB8A
Entrez ID		10615	153527
HPRD ID		10246	08094
Ensembl ID		ENSG00000076382	ENSG00000146007
Uniprot IDs		Q96R06	Q96NC0
PDB IDs			5O9Z 6AHD 7AAV 7ABF 7ABG 7ABI 8H6K 8Q7N 8QO9 8QPE 8QZS
Enriched GO Terms of Interacting Partners?			Regulation Of Microtubule-based Process Cytoskeleton Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Centrosome Negative Regulation Of Nucleobase-containing Compound Metabolic Process Identical Protein Binding Protein Binding Negative Regulation Of RNA Metabolic Process Positive Regulation Of Long-term Neuronal Synaptic Plasticity MRNA Transport Cytoplasm Negative Regulation Of Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Microtubule-based Process RNA Transport Cellular Localization Microtubule Cytoskeleton Organization Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Translation Regulator Activity Cytosol
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