PCGF1 and CBX8

Number of citations of the paper that reports this interaction (PMID 21282530)
11

Data Source:
BioGRID (affinity chromatography technology, pull down)

		PCGF1	CBX8
Gene Name		polycomb group ring finger 1	chromobox homolog 8
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm PcG Protein Complex	Nuclear Chromatin Heterochromatin Nucleus Nucleoplasm PcG Protein Complex PRC1 Complex
	Molecular Function	Protein Binding Protein C-terminus Binding Zinc Ion Binding	Single-stranded RNA Binding Ubiquitin-protein Transferase Activity Protein Binding Methylated Histone Binding
	Biological Process	Transcription, DNA-templated Regulation Of Transcription, DNA-templated Histone H2A Monoubiquitination	Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated Histone Ubiquitination
Pathways			Oxidative Stress Induced Senescence Cellular Senescence
Drugs
Diseases
GWAS
Protein-Protein Interactions		11 interactors: BCORL1 CALCOCO2 CBX6 CBX7 CBX8 PCGF5 RING1 RNF125 RNF2 TRIM55 UBE2U	42 interactors: BMI1 CALCOCO2 CCDC136 CCDC57 EEF1G FSD2 GOLGA2 GPRASP2 HAP1 HIST3H3 HMBOX1 IKZF1 KAT5 KAT7 KCTD9 KIFC3 KRT40 LZTS2 MID2 MLLT1 MLLT3 MTUS2 PAXIP1 PCGF1 PCGF2 PCGF3 PCGF5 PCGF6 PHC2 PNMA2 RING1 RNF2 RPGRIP1 SETDB1 SOX5 TFCP2 TRAF2 TSGA10 UNC119 USP11 USP7 ZBTB14
Entrez ID		84759	57332
HPRD ID		11404	13006
Ensembl ID
Uniprot IDs		Q9BSM1	Q9HC52
PDB IDs		4HPL 4HPM	3I91
Enriched GO Terms of Interacting Partners?		Histone Ubiquitination Chromatin Modification Chromatin Organization Chromosome Organization Protein Ubiquitination Protein Modification By Small Protein Conjugation Histone H2A Monoubiquitination Histone H2A Ubiquitination Transcription, DNA-templated Histone Modification RNA Biosynthetic Process Histone Monoubiquitination Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Organelle Organization Protein Monoubiquitination RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Gene Expression Negative Regulation Of Transcription From RNA Polymerase II Promoter Cellular Macromolecule Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Macromolecule Biosynthetic Process Nitrogen Compound Metabolic Process Histone H2A-K119 Monoubiquitination Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Negative Regulation Of Cellular Metabolic Process Biosynthetic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Anterior/posterior Pattern Specification Sebaceous Gland Development Regulation Of Transcription From RNA Polymerase II Promoter Cellular Metabolic Process Cellular Protein Modification Process Pattern Specification Process Negative Regulation Of Type I Interferon Production Gastrulation With Mouth Forming Second Regulation Of Metabolic Process Anterior/posterior Axis Specification Cellular Protein Metabolic Process	Transcription, DNA-templated RNA Biosynthetic Process Histone Modification Chromatin Modification Chromosome Organization Regulation Of Transcription, DNA-templated Gene Expression Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process RNA Metabolic Process Cellular Macromolecule Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Macromolecule Biosynthetic Process Chromatin Organization Negative Regulation Of RNA Biosynthetic Process Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Nucleobase-containing Compound Metabolic Process Negative Regulation Of Nucleic Acid-templated Transcription Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Histone Ubiquitination Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Gene Expression Negative Regulation Of Transcription, DNA-templated Biosynthetic Process Histone H2A Monoubiquitination Negative Regulation Of Cellular Metabolic Process Nitrogen Compound Metabolic Process Histone H2A Ubiquitination Peptidyl-lysine Modification Regulation Of Metabolic Process Histone Monoubiquitination Negative Regulation Of Transcription From RNA Polymerase II Promoter Protein Ubiquitination Organelle Organization Histone Acetylation Protein Modification By Small Protein Conjugation Internal Peptidyl-lysine Acetylation Peptidyl-lysine Acetylation Internal Protein Amino Acid Acetylation Protein Monoubiquitination Anterior/posterior Pattern Specification Protein Acetylation Regulation Of Transcription From RNA Polymerase II Promoter Cellular Metabolic Process Segment Specification Cellular Protein Modification Process Cellular Response To Reactive Oxygen Species
Tagcloud ?		bcl6 bcor bcorl1 comprises corepressor demethylase diagnosing estimating eukaryotes h3k36me2 inactivating islands kdm2b lenz massively medulloblastoma microphthalmia monoubiquitylation myelomonocytic nonmethylated oculofaciocardiodental perspective polycomb proposes removes ring1b rnf2 silence uniquely	aims approaches beings blotting causes chromobox colon conclude cultured express facilitating hct116 homolog igf1 igf1r knockdown leading line overexpression pathogenesis proliferation promote promoting real reports rt silencing unclear western
Tagcloud (Difference) ?		bcl6 bcor bcorl1 comprises corepressor demethylase diagnosing estimating eukaryotes h3k36me2 inactivating islands kdm2b lenz massively medulloblastoma microphthalmia monoubiquitylation myelomonocytic nonmethylated oculofaciocardiodental perspective polycomb proposes removes ring1b rnf2 silence uniquely	aims approaches beings blotting causes chromobox colon conclude cultured express facilitating hct116 homolog igf1 igf1r knockdown leading line overexpression pathogenesis proliferation promote promoting real reports rt silencing unclear western
Tagcloud (Intersection) ?