PCGF1 and RING1

Number of citations of the paper that reports this interaction (PMID 22493164)
2

Data Source:
BioGRID (two hybrid)

		PCGF1	RING1
Gene Name		polycomb group ring finger 1	ring finger protein 1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm PcG Protein Complex	Sex Chromatin Nucleus Nucleoplasm Cytoplasm Nuclear Speck PcG Protein Complex PRC1 Complex
	Molecular Function	Protein Binding Protein C-terminus Binding Zinc Ion Binding	Chromatin Binding Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Ligase Activity
	Biological Process	Transcription, DNA-templated Regulation Of Transcription, DNA-templated Histone H2A Monoubiquitination	Transcription, DNA-templated Anterior/posterior Pattern Specification Histone H2A Monoubiquitination Negative Regulation Of Transcription, DNA-templated Camera-type Eye Morphogenesis
Pathways			Oxidative Stress Induced Senescence Cellular Senescence
Drugs
Diseases
GWAS			Wegener's granulomatosis ( 23740775)
Protein-Protein Interactions		11 interactors: BCORL1 CALCOCO2 CBX6 CBX7 CBX8 PCGF5 RING1 RNF125 RNF2 TRIM55 UBE2U	31 interactors: APP BMI1 CBX4 CBX6 CBX7 CBX8 E2F6 ELAC2 FBXO38 FHL1 HIST3H3 PCGF1 PCGF2 PCGF3 PCGF5 PCGF6 PHC1 PIK3R3 RB1 RNF2 RYBP UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2K USP7 YAF2
Entrez ID		84759	6015
HPRD ID		11404	03624
Ensembl ID			ENSG00000204227
Uniprot IDs		Q9BSM1	Q06587
PDB IDs		4HPL 4HPM
Enriched GO Terms of Interacting Partners?		Histone Ubiquitination Chromatin Modification Chromatin Organization Chromosome Organization Protein Ubiquitination Protein Modification By Small Protein Conjugation Histone H2A Monoubiquitination Histone H2A Ubiquitination Transcription, DNA-templated Histone Modification RNA Biosynthetic Process Histone Monoubiquitination Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Organelle Organization Protein Monoubiquitination RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Gene Expression Negative Regulation Of Transcription From RNA Polymerase II Promoter Cellular Macromolecule Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Macromolecule Biosynthetic Process Nitrogen Compound Metabolic Process Histone H2A-K119 Monoubiquitination Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Negative Regulation Of Cellular Metabolic Process Biosynthetic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Anterior/posterior Pattern Specification Sebaceous Gland Development Regulation Of Transcription From RNA Polymerase II Promoter Cellular Metabolic Process Cellular Protein Modification Process Pattern Specification Process Negative Regulation Of Type I Interferon Production Gastrulation With Mouth Forming Second Regulation Of Metabolic Process Anterior/posterior Axis Specification Cellular Protein Metabolic Process	Protein Modification By Small Protein Conjugation Protein Ubiquitination Protein K48-linked Ubiquitination Histone Ubiquitination Chromatin Modification Chromatin Organization Negative Regulation Of Transcription From RNA Polymerase II Promoter Chromosome Organization Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Protein Polyubiquitination Negative Regulation Of Gene Expression Transcription, DNA-templated Negative Regulation Of Biosynthetic Process RNA Biosynthetic Process RNA Metabolic Process Cellular Metabolic Process Negative Regulation Of Cellular Metabolic Process Histone Modification Regulation Of Transcription From RNA Polymerase II Promoter Gene Expression Protein Monoubiquitination Nucleobase-containing Compound Metabolic Process Cellular Protein Modification Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Histone Monoubiquitination Regulation Of RNA Metabolic Process Cellular Nitrogen Compound Metabolic Process Protein K11-linked Ubiquitination Regulation Of Gene Expression Nitrogen Compound Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Regulation Of Mitotic Cell Cycle Phase Transition Histone H2A Monoubiquitination Regulation Of Cell Cycle Phase Transition Cellular Protein Metabolic Process Regulation Of Metabolic Process Histone H2A Ubiquitination Organelle Organization Metabolic Process Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Regulation Of Proteasomal Protein Catabolic Process
Tagcloud ?		bcl6 bcor bcorl1 comprises corepressor demethylase diagnosing estimating eukaryotes h3k36me2 inactivating islands kdm2b lenz massively medulloblastoma microphthalmia monoubiquitylation myelomonocytic nonmethylated oculofaciocardiodental perspective polycomb proposes removes ring1b rnf2 silence uniquely	4h accomplish antioxidant ck cmv cortex creatine de dehydrogenase downregulated e3 electrophoresis extremely finger hselm lactate ldh ligase nontg secretase sel selenium selenoprotein selm spots synaptotagmin sytxv tg upregulated
Tagcloud (Difference) ?		bcl6 bcor bcorl1 comprises corepressor demethylase diagnosing estimating eukaryotes h3k36me2 inactivating islands kdm2b lenz massively medulloblastoma microphthalmia monoubiquitylation myelomonocytic nonmethylated oculofaciocardiodental perspective polycomb proposes removes ring1b rnf2 silence uniquely	4h accomplish antioxidant ck cmv cortex creatine de dehydrogenase downregulated e3 electrophoresis extremely finger hselm lactate ldh ligase nontg secretase sel selenium selenoprotein selm spots synaptotagmin sytxv tg upregulated
Tagcloud (Intersection) ?