PCGF1 and CBX6

Number of citations of the paper that reports this interaction (PMID 21282530)
11

Data Source:
BioGRID (pull down)

		PCGF1	CBX6
Gene Name		polycomb group ring finger 1	chromobox homolog 6
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm PcG Protein Complex	Heterochromatin Nucleus Nucleoplasm PcG Protein Complex
	Molecular Function	Protein Binding Protein C-terminus Binding Zinc Ion Binding	Single-stranded RNA Binding Protein Binding
	Biological Process	Transcription, DNA-templated Regulation Of Transcription, DNA-templated Histone H2A Monoubiquitination	Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated Chromatin Modification
Pathways			Oxidative Stress Induced Senescence Cellular Senescence
Drugs
Diseases
GWAS			Bladder cancer ( 20972438)
Protein-Protein Interactions		11 interactors: BCORL1 CALCOCO2 CBX6 CBX7 CBX8 PCGF5 RING1 RNF125 RNF2 TRIM55 UBE2U	9 interactors: BMI1 HOXC9 PCGF1 PCGF2 PCGF3 PCGF5 PCGF6 RING1 RNF2
Entrez ID		84759	23466
HPRD ID		11404	13005
Ensembl ID			ENSG00000183741
Uniprot IDs		Q9BSM1	B0QXZ6 O95503
PDB IDs		4HPL 4HPM	3GV6 3I90
Enriched GO Terms of Interacting Partners?		Histone Ubiquitination Chromatin Modification Chromatin Organization Chromosome Organization Protein Ubiquitination Protein Modification By Small Protein Conjugation Histone H2A Monoubiquitination Histone H2A Ubiquitination Transcription, DNA-templated Histone Modification RNA Biosynthetic Process Histone Monoubiquitination Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Organelle Organization Protein Monoubiquitination RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Gene Expression Negative Regulation Of Transcription From RNA Polymerase II Promoter Cellular Macromolecule Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Macromolecule Biosynthetic Process Nitrogen Compound Metabolic Process Histone H2A-K119 Monoubiquitination Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Negative Regulation Of Cellular Metabolic Process Biosynthetic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Anterior/posterior Pattern Specification Sebaceous Gland Development Regulation Of Transcription From RNA Polymerase II Promoter Cellular Metabolic Process Cellular Protein Modification Process Pattern Specification Process Negative Regulation Of Type I Interferon Production Gastrulation With Mouth Forming Second Regulation Of Metabolic Process Anterior/posterior Axis Specification Cellular Protein Metabolic Process	Histone Ubiquitination Transcription, DNA-templated RNA Biosynthetic Process Histone H2A Monoubiquitination Histone H2A Ubiquitination Anterior/posterior Pattern Specification RNA Metabolic Process Gene Expression Histone Monoubiquitination Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Histone Modification Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Pattern Specification Process Protein Monoubiquitination Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Protein Ubiquitination Chromatin Modification Protein Modification By Small Protein Conjugation Nitrogen Compound Metabolic Process Chromatin Organization Embryonic Skeletal System Morphogenesis Chromosome Organization Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Embryonic Skeletal System Development Regulation Of Metabolic Process Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Embryonic Morphogenesis Skeletal System Morphogenesis Negative Regulation Of Transcription From RNA Polymerase II Promoter Embryonic Organ Morphogenesis Organ Morphogenesis Negative Regulation Of Cellular Metabolic Process Cellular Metabolic Process Embryo Development Embryonic Organ Development Histone H2A-K119 Monoubiquitination Histone Acetylation
Tagcloud ?		bcl6 bcor bcorl1 comprises corepressor demethylase diagnosing estimating eukaryotes h3k36me2 inactivating islands kdm2b lenz massively medulloblastoma microphthalmia monoubiquitylation myelomonocytic nonmethylated oculofaciocardiodental perspective polycomb proposes removes ring1b rnf2 silence uniquely	acetylase aldh1a3 belonging bipotent ccnb1 ccne1 committed differentiated disrupt dysregulation encode establishment gata3 hat1 hdac1 identity luminal maintenance myoepithelial notch4 pcgf2 polycomb progenitors silico smarca4 smarcd3 smarce1 subpopulations trithorax
Tagcloud (Difference) ?		bcl6 bcor bcorl1 comprises corepressor demethylase diagnosing estimating eukaryotes h3k36me2 inactivating islands kdm2b lenz massively medulloblastoma microphthalmia monoubiquitylation myelomonocytic nonmethylated oculofaciocardiodental perspective proposes removes ring1b rnf2 silence uniquely	acetylase aldh1a3 belonging bipotent ccnb1 ccne1 committed differentiated disrupt dysregulation encode establishment gata3 hat1 hdac1 identity luminal maintenance myoepithelial notch4 pcgf2 progenitors silico smarca4 smarcd3 smarce1 subpopulations trithorax
Tagcloud (Intersection) ?		polycomb