PRRC2B and GTF3C4

		PRRC2B	GTF3C4
Description		proline rich coiled-coil 2B	general transcription factor IIIC subunit 4
Image		No pdb structure
GO Annotations	Cellular Component		Transcription Factor TFIIIC Complex Nucleus Nucleoplasm Mitochondrion
	Molecular Function	RNA Binding Protein Binding	RNA Polymerase III General Transcription Initiation Factor Activity DNA Binding Histone Acetyltransferase Activity Protein Binding Transferase Activity Acyltransferase Activity Histone H3K14 Acetyltransferase Activity Protein-lysine-acetyltransferase Activity
	Biological Process	Cell Differentiation	Chromatin Remodeling Transcription By RNA Polymerase III Transcription Initiation At RNA Polymerase III Promoter 5S Class RRNA Transcription By RNA Polymerase III TRNA Transcription By RNA Polymerase III
Pathways			RNA Polymerase III Abortive And Retractive Initiation RNA Polymerase III Transcription Initiation From Type 1 Promoter RNA Polymerase III Transcription Initiation From Type 1 Promoter RNA Polymerase III Transcription Initiation From Type 2 Promoter RNA Polymerase III Transcription Initiation From Type 2 Promoter
Drugs
Diseases
GWAS		Femur bone mineral density x serum urate levels interaction ( 34046847) Lung function ( 31902109) Urate levels ( 31578528)
Interacting Genes		41 interacting genes: ALG13 ANKHD1 APP ATN1 ATXN1 ATXN1L BAG4 BCAS2 CRK CTBP1 DAPK1 DDX11 DIMT1 DMRTB1 DNAJC5 DPY30 EHMT2 ESS2 EXOSC1 EXOSC4 EXOSC7 FBXO7 IPO5 LSM5 MRPL44 NIP7 NXF1 NXF5 PRPF39 QKI RBFOX2 RBPMS RERE RPL13 SF1 SRPK2 SRSF4 TRNAU1AP TXNL4A YTHDF1 YTHDF3	13 interacting genes: AURKA BRCA1 BRF1 ETS2 GTF3C1 GTF3C2 GTF3C5 H3-4 H3C15 POLR3C POLR3F SUMO2 TBP
Entrez ID		84726	9329
HPRD ID		13805	11998
Ensembl ID		ENSG00000288701	ENSG00000125484
Uniprot IDs		Q5JSZ5 Q9BU62	B3KNH2 Q9UKN8
PDB IDs			8CLI 8CLJ 8CLL
Enriched GO Terms of Interacting Partners?		RNA Binding Nucleus RNA Processing RNA Metabolic Process Nucleic Acid Binding RNA Splicing MRNA Metabolic Process Nucleolus MRNA Processing MRNA Binding Nucleoplasm Nucleic Acid Metabolic Process Nucleobase-containing Compound Metabolic Process RNA Splicing, Via Transesterification Reactions Nucleolar Exosome (RNase Complex) Regulation Of MRNA Metabolic Process Cytoplasmic Stress Granule Cytoplasmic Exosome (RNase Complex) RNA Exonuclease Activity Macromolecule Metabolic Process Regulation Of RNA Splicing Nuclear Exosome (RNase Complex) Exosome (RNase Complex) Regulation Of MRNA Splicing, Via Spliceosome MRNA Splicing, Via Spliceosome Regulation Of MRNA Processing POZ Domain Binding Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Stress Granule Assembly Negative Regulation Of Macromolecule Metabolic Process MRNA Splice Site Recognition Exoribonuclease Complex Regulation Of Macromolecule Biosynthetic Process Regulation Of RNA Metabolic Process Spliceosomal Complex Nuclear RNA Export Factor Complex U4 SnRNA 3'-end Processing Protein-RNA Complex Assembly Cytoplasm Transcription Corepressor Activity Negative Regulation Of Metabolic Process Spliceosomal Complex Assembly Memory Negative Regulation Of RNA Metabolic Process Regulation Of Macromolecule Metabolic Process Nuclear MRNA Surveillance Nuclear Inclusion Body N6-methyladenosine-containing RNA Reader Activity	Transcription By RNA Polymerase III RNA Polymerase III General Transcription Initiation Factor Activity TRNA Transcription RRNA Transcription Transcription Factor TFIIIC Complex 5S Class RRNA Transcription By RNA Polymerase III Transcription Initiation At RNA Polymerase III Promoter DNA-templated Transcription Nucleoplasm TRNA Transcription By RNA Polymerase III DNA-templated Transcription Initiation DNA Binding Nucleobase-containing Compound Biosynthetic Process Macromolecule Biosynthetic Process Protein-DNA Complex Assembly Pronucleus TRNA Metabolic Process Nucleus RRNA Metabolic Process RNA Metabolic Process Nucleic Acid Metabolic Process RNA Polymerase III Complex Macromolecule Metabolic Process Regulation Of Transcription By RNA Polymerase III DNA-directed RNA Polymerase Activity Nucleobase-containing Compound Metabolic Process DNA-directed RNA Polymerase Complex Positive Regulation Of Interferon-beta Production Centrosome Cycle Condensed Nuclear Chromosome Male Germ Cell Nucleus Regulation Of Centrosome Cycle Regulation Of Interferon-beta Production Transcription Preinitiation Complex Assembly Histone H2AK127 Ubiquitin Ligase Activity Chromatin Remodeling Histone H2AK129 Ubiquitin Ligase Activity BRCA1-BARD1 Complex Ectodermal Cell Fate Commitment Ubiquitin Protein Ligase Binding Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Microtubule Organizing Center Organization Structural Constituent Of Chromatin Transcription Factor TFIIIB Complex Protein Heterodimerization Activity Positive Regulation Of Oocyte Maturation RNA Polymerase III Type 1 Promoter Sequence-specific DNA Binding RNA Polymerase III Type 2 Promoter Sequence-specific DNA Binding Positive Regulation Of Type I Interferon Production BRCA1-B Complex
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