GTF3C4 and GTF3C5

Number of citations of the paper that reports this interaction (PubMedID 37761933)
99

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vitro, in vivo)

		GTF3C4	GTF3C5
Description		general transcription factor IIIC subunit 4	general transcription factor IIIC subunit 5
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GO Annotations	Cellular Component	Transcription Factor TFIIIC Complex Nucleus Nucleoplasm Mitochondrion	Transcription Factor TFIIIC Complex Nucleus Nucleoplasm
	Molecular Function	RNA Polymerase III General Transcription Initiation Factor Activity DNA Binding Histone Acetyltransferase Activity Protein Binding Transferase Activity Acyltransferase Activity Histone H3K14 Acetyltransferase Activity Protein-lysine-acetyltransferase Activity	RNA Polymerase III General Transcription Initiation Factor Activity RNA Polymerase III Type 1 Promoter Sequence-specific DNA Binding RNA Polymerase III Type 2 Promoter Sequence-specific DNA Binding DNA Binding Protein Binding
	Biological Process	Chromatin Remodeling Transcription By RNA Polymerase III Transcription Initiation At RNA Polymerase III Promoter 5S Class RRNA Transcription By RNA Polymerase III TRNA Transcription By RNA Polymerase III	Transcription By RNA Polymerase III Transcription Initiation At RNA Polymerase III Promoter Skeletal Muscle Cell Differentiation 5S Class RRNA Transcription By RNA Polymerase III TRNA Transcription By RNA Polymerase III
Pathways		RNA Polymerase III Abortive And Retractive Initiation RNA Polymerase III Transcription Initiation From Type 1 Promoter RNA Polymerase III Transcription Initiation From Type 1 Promoter RNA Polymerase III Transcription Initiation From Type 2 Promoter RNA Polymerase III Transcription Initiation From Type 2 Promoter	RNA Polymerase III Abortive And Retractive Initiation RNA Polymerase III Transcription Initiation From Type 1 Promoter RNA Polymerase III Transcription Initiation From Type 1 Promoter RNA Polymerase III Transcription Initiation From Type 2 Promoter RNA Polymerase III Transcription Initiation From Type 2 Promoter
Drugs
Diseases
GWAS			Sepsis (28-day mortality) ( 32592749)
Interacting Genes		13 interacting genes: AURKA BRCA1 BRF1 ETS2 GTF3C1 GTF3C2 GTF3C5 H3-4 H3C15 POLR3C POLR3F SUMO2 TBP	16 interacting genes: BRF1 DNMT3L GTF3C3 GTF3C4 KRT40 KRTAP10-3 KRTAP12-3 MDFI NOTCH2NLA OGT PTEN RPTOR SRA1 TBP TCF21 TCF4
Entrez ID		9329	9328
HPRD ID		11998	16077
Ensembl ID		ENSG00000125484	ENSG00000148308
Uniprot IDs		B3KNH2 Q9UKN8	H7BY84 Q9Y5Q8
PDB IDs		8CLI 8CLJ 8CLL	8CLK
Enriched GO Terms of Interacting Partners?		Transcription By RNA Polymerase III RNA Polymerase III General Transcription Initiation Factor Activity TRNA Transcription RRNA Transcription Transcription Factor TFIIIC Complex 5S Class RRNA Transcription By RNA Polymerase III Transcription Initiation At RNA Polymerase III Promoter DNA-templated Transcription Nucleoplasm TRNA Transcription By RNA Polymerase III DNA-templated Transcription Initiation DNA Binding Nucleobase-containing Compound Biosynthetic Process Macromolecule Biosynthetic Process Protein-DNA Complex Assembly Pronucleus TRNA Metabolic Process Nucleus RRNA Metabolic Process RNA Metabolic Process Nucleic Acid Metabolic Process RNA Polymerase III Complex Macromolecule Metabolic Process Regulation Of Transcription By RNA Polymerase III DNA-directed RNA Polymerase Activity Nucleobase-containing Compound Metabolic Process DNA-directed RNA Polymerase Complex Positive Regulation Of Interferon-beta Production Centrosome Cycle Condensed Nuclear Chromosome Male Germ Cell Nucleus Regulation Of Centrosome Cycle Regulation Of Interferon-beta Production Transcription Preinitiation Complex Assembly Histone H2AK127 Ubiquitin Ligase Activity Chromatin Remodeling Histone H2AK129 Ubiquitin Ligase Activity BRCA1-BARD1 Complex Ectodermal Cell Fate Commitment Ubiquitin Protein Ligase Binding Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Microtubule Organizing Center Organization Structural Constituent Of Chromatin Transcription Factor TFIIIB Complex Protein Heterodimerization Activity Positive Regulation Of Oocyte Maturation RNA Polymerase III Type 1 Promoter Sequence-specific DNA Binding RNA Polymerase III Type 2 Promoter Sequence-specific DNA Binding Positive Regulation Of Type I Interferon Production BRCA1-B Complex	RNA Polymerase III General Transcription Initiation Factor Activity Transcription By RNA Polymerase III TRNA Transcription RRNA Transcription TFIIB-class Transcription Factor Binding Transcription Factor TFIIIC Complex 5S Class RRNA Transcription By RNA Polymerase III Transcription Initiation At RNA Polymerase III Promoter DNA-templated Transcription Initiation TRNA Transcription By RNA Polymerase III Keratin Filament Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Intermediate Filament RRNA Metabolic Process DNA-templated Transcription TRNA Metabolic Process Protein-DNA Complex Assembly Macromolecule Biosynthetic Process Transcription Preinitiation Complex Assembly Regulation Of DNA-templated Transcription Regulation Of RNA Metabolic Process Regulation Of RNA Biosynthetic Process Negative Regulation Of Synaptic Vesicle Clustering Social Behavior Phosphatidylinositol-3,4-bisphosphate 3-phosphatase Activity Negative Regulation Of Keratinocyte Migration Inositol-1,3,4,5-tetrakisphosphate 3-phosphatase Activity Positive Regulation Of RNA Metabolic Process Positive Regulation Of Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Inositol-1,3,4,5,6-pentakisphosphate 3-phosphatase Activity Positive Regulation Of Macromolecule Biosynthetic Process E-box Binding Protein Localization To Lysosome Protein N-acetylglucosaminyltransferase Complex Cellular Response To Glucose Stimulus Negative Regulation Of Non-canonical Inflammasome Complex Assembly Regulation Of Carbohydrate Catabolic Process Regulation Of Glycolytic Process Positive Regulation Of TORC1 Signaling Negative Regulation Of Translational Initiation Positive Regulation Of Translational Initiation TORC1 Signaling Steroid Receptor RNA Activator RNA Binding Negative Regulation Of DNA Methylation-dependent Heterochromatin Formation Regulation Of ATP Metabolic Process Cellular Response To Carbohydrate Stimulus Transcription Factor TFIIIB Complex Cellular Developmental Process
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