GTF3C4 and POLR3F

Number of citations of the paper that reports this interaction (PubMedID 10523658)
54

Data Source:
HPRD (in vitro, in vivo)

		GTF3C4	POLR3F
Description		general transcription factor IIIC subunit 4	RNA polymerase III subunit F
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GO Annotations	Cellular Component	Transcription Factor TFIIIC Complex Nucleus Nucleoplasm Mitochondrion	DNA-directed RNA Polymerase Complex Nucleus Nucleoplasm RNA Polymerase III Complex Cytoplasm Cytosol
	Molecular Function	RNA Polymerase III General Transcription Initiation Factor Activity DNA Binding Histone Acetyltransferase Activity Protein Binding Transferase Activity Acyltransferase Activity Histone H3K14 Acetyltransferase Activity Protein-lysine-acetyltransferase Activity	DNA Binding Double-stranded DNA Binding DNA-directed RNA Polymerase Activity Protein Binding 4 Iron, 4 Sulfur Cluster Binding
	Biological Process	Chromatin Remodeling Transcription By RNA Polymerase III Transcription Initiation At RNA Polymerase III Promoter 5S Class RRNA Transcription By RNA Polymerase III TRNA Transcription By RNA Polymerase III	Immune System Process Regulation Of Transcription By RNA Polymerase III Transcription By RNA Polymerase III Positive Regulation Of Interferon-beta Production Innate Immune Response Positive Regulation Of Innate Immune Response Defense Response To Virus
Pathways		RNA Polymerase III Abortive And Retractive Initiation RNA Polymerase III Transcription Initiation From Type 1 Promoter RNA Polymerase III Transcription Initiation From Type 1 Promoter RNA Polymerase III Transcription Initiation From Type 2 Promoter RNA Polymerase III Transcription Initiation From Type 2 Promoter	Cytosolic sensors of pathogen-associated DNA RNA Polymerase III Chain Elongation RNA Polymerase III Transcription Termination RNA Polymerase III Abortive And Retractive Initiation RNA Polymerase III Transcription Initiation From Type 1 Promoter RNA Polymerase III Transcription Initiation From Type 1 Promoter RNA Polymerase III Transcription Initiation From Type 2 Promoter RNA Polymerase III Transcription Initiation From Type 2 Promoter RNA Polymerase III Transcription Initiation From Type 3 Promoter RNA Polymerase III Transcription Initiation From Type 3 Promoter
Drugs
Diseases
GWAS			Refractive error ( 32231278)
Interacting Genes		13 interacting genes: AURKA BRCA1 BRF1 ETS2 GTF3C1 GTF3C2 GTF3C5 H3-4 H3C15 POLR3C POLR3F SUMO2 TBP	15 interacting genes: ATPAF2 BDP1 BRF1 ERG28 GTF3C4 KAT5 LRIF1 PRP4K RIN3 STC2 SUV39H2 TBP TNS2 UBE2G2 WDR89
Entrez ID		9329	10621
HPRD ID		11998	15156
Ensembl ID		ENSG00000125484	ENSG00000132664
Uniprot IDs		B3KNH2 Q9UKN8	A0A8V8TL53 A0A8V8TMS0 Q05DB8 Q9H1D9
PDB IDs		8CLI 8CLJ 8CLL	2DK5 2YU3 7A6H 7AE1 7AE3 7AEA 7AST 7D58 7D59 7DN3 7DU2 7FJI 7FJJ 8ITY 8IUE 8IUH 9FSO 9FSP 9FSQ 9FSR 9FSS
Enriched GO Terms of Interacting Partners?		Transcription By RNA Polymerase III RNA Polymerase III General Transcription Initiation Factor Activity TRNA Transcription RRNA Transcription Transcription Factor TFIIIC Complex 5S Class RRNA Transcription By RNA Polymerase III Transcription Initiation At RNA Polymerase III Promoter DNA-templated Transcription Nucleoplasm TRNA Transcription By RNA Polymerase III DNA-templated Transcription Initiation DNA Binding Nucleobase-containing Compound Biosynthetic Process Macromolecule Biosynthetic Process Protein-DNA Complex Assembly Pronucleus TRNA Metabolic Process Nucleus RRNA Metabolic Process RNA Metabolic Process Nucleic Acid Metabolic Process RNA Polymerase III Complex Macromolecule Metabolic Process Regulation Of Transcription By RNA Polymerase III DNA-directed RNA Polymerase Activity Nucleobase-containing Compound Metabolic Process DNA-directed RNA Polymerase Complex Positive Regulation Of Interferon-beta Production Centrosome Cycle Condensed Nuclear Chromosome Male Germ Cell Nucleus Regulation Of Centrosome Cycle Regulation Of Interferon-beta Production Transcription Preinitiation Complex Assembly Histone H2AK127 Ubiquitin Ligase Activity Chromatin Remodeling Histone H2AK129 Ubiquitin Ligase Activity BRCA1-BARD1 Complex Ectodermal Cell Fate Commitment Ubiquitin Protein Ligase Binding Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Microtubule Organizing Center Organization Structural Constituent Of Chromatin Transcription Factor TFIIIB Complex Protein Heterodimerization Activity Positive Regulation Of Oocyte Maturation RNA Polymerase III Type 1 Promoter Sequence-specific DNA Binding RNA Polymerase III Type 2 Promoter Sequence-specific DNA Binding Positive Regulation Of Type I Interferon Production BRCA1-B Complex	RNA Polymerase III General Transcription Initiation Factor Activity Transcription By RNA Polymerase III Transcription Factor TFIIIB Complex Transcription Initiation At RNA Polymerase III Promoter Transcription Preinitiation Complex Assembly TRNA Transcription DNA-templated Transcription Initiation RRNA Transcription Protein-lysine-acetyltransferase Activity Histone Acetyltransferase Activity Chromosome, Centromeric Region Protein-DNA Complex Assembly Histone H2AK5 Acetyltransferase Activity RNA Polymerase III Preinitiation Complex Assembly Negative Regulation Of Mast Cell Chemotaxis
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