CAMK2N2 and ARHGAP32

Number of citations: 0 (PubMedID 12531901)
Data Source: HPRD (in vitro)

		CAMK2N2	ARHGAP32
Name		calcium/calmodulin dependent protein kinase II inhibitor 2	Rho GTPase activating protein 32
Structure		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Synapse	Golgi Membrane Fibrillar Center Nucleoplasm Cytoplasm Endosome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Cytosol Cell Cortex Endosome Membrane Postsynaptic Density Actin Cytoskeleton Membrane Cell Projection Dendritic Spine Synapse
	Molecular Function	Protein Kinase Inhibitor Activity Calcium-dependent Protein Kinase Inhibitor Activity Protein Kinase Binding	GTPase Activator Activity Protein Binding Phosphatidylinositol Binding Phosphatidylinositol Phosphate Binding
	Biological Process	None	Signal Transduction Small GTPase-mediated Signal Transduction Regulation Of Small GTPase Mediated Signal Transduction
Pathways		None	RHOA GTPase cycle RHOB GTPase cycle RHOC GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle RAC2 GTPase cycle RHOD GTPase cycle RHOQ GTPase cycle RHOG GTPase cycle RHOJ GTPase cycle RAC3 GTPase cycle RHOF GTPase cycle Regulation of CDH1 posttranslational processing and trafficking to plasma membrane
GWAS		Major depressive disorder ( 22472876 )	Intracranial aneurysm ( 30823506 ) Iris color (L* coordinate) ( 29109912 ) Macular thickness ( 30535121 ) Metabolite levels (5-HIAA) ( 23319000 ) Refractive error ( 32231278 )
Interacting Genes		4 interacting genes: ARHGAP32 CAMK2A CAMK2B LNX1	33 interacting genes: ABI2 ATXN1 BCAR1 CAMK2N2 CDC42 CDH1 CDH2 CRK CRKL CTNNB1 DLG4 DZIP3 FYN GAB1 GAB2 GRAP GRB2 GRIN2A GRIN2B LHX2 MDFI MEGF10 NCK1 NCK2 NPHP1 NTRK1 PIK3R1 PLCG1 RAC1 RHOA SHC3 SRC TLE5
Entrez ID		94032	9743
HPRD ID		16377	12257
Ensembl ID		ENSG00000163888	ENSG00000134909
Uniprot IDs		Q96S95	A0A804HK06 A7KAX9
PDB IDs		Not available	3IUG
GO Terms Enriched among Interactors		Calcium- And Calmodulin-dependent Protein Kinase Complex Calcium/calmodulin-dependent Protein Kinase Activity Postsynaptic Density Long-term Synaptic Potentiation Regulation Of Neuronal Synaptic Plasticity Regulation Of Neuron Migration Endocytic Vesicle Membrane Peptidyl-threonine Autophosphorylation Regulation Of Protein Localization To Plasma Membrane Protein Autophosphorylation Regulation Of Protein Localization To Cell Periphery Dendritic Spine Positive Regulation Of Synaptic Transmission Synapse Regulation Of Protein Localization To Membrane Regulation Of Endocannabinoid Signaling Pathway Calmodulin Binding Regulation Of Synaptic Plasticity Regulation Of Calcium Ion Transport Glutamate Receptor Binding Regulation Of Synapse Structural Plasticity Positive Regulation Of Synapse Maturation Protein Serine Kinase Activity Protein Phosphorylation Neuron Projection Regulation Of Metal Ion Transport Regulation Of Skeletal Muscle Adaptation Protein Modification Process Phosphorylation Positive Regulation Of Cardiac Muscle Cell Apoptotic Process Dendritic Spine Development Protein Serine/threonine Kinase Activity Regulation Of Monoatomic Ion Transport Transferase Activity Synapse Maturation Identical Protein Binding Positive Regulation Of Dendritic Spine Morphogenesis Angiotensin-activated Signaling Pathway Protein Kinase Activity Peptidyl-threonine Phosphorylation Modulation Of Chemical Synaptic Transmission Regulation Of Cellular Localization Regulation Of Mitochondrial Membrane Permeability Involved In Apoptotic Process Cellular Response To Interferon-beta Regulation Of Long-term Neuronal Synaptic Plasticity Nervous System Development Regulation Of Synapse Maturation Phosphatidylinositol Phosphate Binding Kinase Activity Response To Interferon-beta	Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Cell Migration Cell Surface Receptor Signaling Pathway Cell Motility Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Phosphotyrosine Residue Binding Regulation Of Cell Projection Organization Positive Regulation Of Cell Adhesion Regulation Of Cell Adhesion Regulation Of Plasma Membrane Bounded Cell Projection Organization Signal Transduction Cell-cell Junction Ephrin Receptor Signaling Pathway Regulation Of Signal Transduction Developmental Process Positive Regulation Of Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Regulation Of Cellular Component Organization Regulation Of MAPK Cascade Positive Regulation Of Cellular Component Biogenesis Ephrin Receptor Binding Lamellipodium Intracellular Signaling Cassette Intracellular Signal Transduction Regulation Of Synapse Organization Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Lamellipodium Organization Positive Regulation Of Cellular Component Organization Positive Regulation Of Intracellular Signal Transduction Protein Kinase Binding Signaling Adaptor Activity Neuron Migration Regulation Of Cell Migration Regulation Of Actin Cytoskeleton Organization Positive Regulation Of Cell Projection Organization Establishment Or Maintenance Of Cell Polarity Regulation Of Cell Motility Regulation Of Intracellular Signal Transduction Actin Filament Organization Regulation Of Actin Filament Organization Positive Regulation Of Supramolecular Fiber Organization Regulation Of Actin Filament-based Process Regulation Of Locomotion Cell-cell Junction Organization Regulation Of Lamellipodium Organization Cell Projection Organization