CAMK2N2 and ARHGAP32

Number of citations of the paper that reports this interaction (PMID 12531901)
31

Data Source:
HPRD (in vitro)

		CAMK2N2	ARHGAP32
Gene Name		calcium/calmodulin-dependent protein kinase II inhibitor 2	Rho GTPase activating protein 32
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Centrosome Cytosol	Golgi Membrane Endoplasmic Reticulum Membrane Cytosol Cell Cortex Endosome Membrane Postsynaptic Density Actin Cytoskeleton Cell Junction Dendritic Spine Postsynaptic Membrane
	Molecular Function	Calcium-dependent Protein Kinase Inhibitor Activity Protein Kinase Binding	GTPase Activator Activity Protein Binding Phosphatidylinositol Binding
	Biological Process	Negative Regulation Of Protein Kinase Activity	Small GTPase Mediated Signal Transduction Positive Regulation Of GTPase Activity Regulation Of Small GTPase Mediated Signal Transduction
Pathways			Rho GTPase cycle Signaling by Rho GTPases
Drugs
Diseases
GWAS		Major depressive disorder ( 22472876)	Metabolite levels (5-HIAA) ( 23319000)
Protein-Protein Interactions		4 interactors: ARHGAP32 CAMK2A CAMK2B LNX1	34 interactors: ABI2 AES AKT1 ATXN1 BCAR1 CAMK2N2 CDC42 CDH1 CDH2 CRK CRKL CTNNB1 DLG4 DZIP3 FYN GAB1 GAB2 GRAP GRB2 GRIN2A GRIN2B LZTS2 MDFI MEGF10 NCK1 NCK2 NPHP1 NTRK1 PIK3R1 PLCG1 RAC1 RHOA SHC3 SRC
Entrez ID		94032	9743
HPRD ID		16377	12257
Ensembl ID		ENSG00000163888	ENSG00000134909
Uniprot IDs		Q96S95	A7KAX9 I7H0B0 Q86T64
PDB IDs			3IUG
Enriched GO Terms of Interacting Partners?		Regulation Of Cellular Response To Heat Regulation Of Neuronal Synaptic Plasticity Cellular Response To Heat Response To Heat Peptidyl-serine Phosphorylation Interferon-gamma-mediated Signaling Pathway Inhibitory G-protein Coupled Receptor Phosphorylation Cellular Response To Interferon-gamma G1/S Transition Of Mitotic Cell Cycle Regulation Of Synaptic Plasticity Response To Interferon-gamma Activation Of Meiosis Involved In Egg Activation Response To Temperature Stimulus Regulation Of Calcium Ion Transport Protein Autophosphorylation Activation Of Meiosis Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Regulation Of Synaptic Transmission Calcium Ion Transport Regulation Of Synaptic Transmission, Cholinergic Regulation Of Skeletal Muscle Adaptation Regulation Of Synapse Structural Plasticity Cytokine-mediated Signaling Pathway Positive Regulation Of Cardiac Muscle Cell Apoptotic Process Positive Regulation Of Dendritic Spine Morphogenesis Positive Regulation Of Synapse Maturation Desensitization Of G-protein Coupled Receptor Protein Signaling Pathway Positive Regulation Of Meiotic Nuclear Division Egg Activation Regulation Of Synapse Maturation Regulation Of Mitochondrial Membrane Permeability Involved In Apoptotic Process Cellular Response To Cytokine Stimulus Synaptic Transmission Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Regulation Of Ion Transport Positive Regulation Of Dendritic Spine Development Mitotic Cell Cycle Process Response To Cytokine Regulation Of Long-term Neuronal Synaptic Plasticity Response To Ischemia Regulation Of Mitochondrial Membrane Permeability Regulation Of Dendritic Spine Morphogenesis Mitotic Cell Cycle Regulation Of Membrane Permeability Positive Regulation Of Dendrite Morphogenesis Innate Immune Response Metal Ion Transport	Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Vascular Endothelial Growth Factor Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Signaling Regulation Of Signal Transduction System Development Positive Regulation Of Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Locomotion ERBB Signaling Pathway Multicellular Organismal Development Cellular Response To Growth Factor Stimulus Response To Growth Factor Anatomical Structure Development Fc Receptor Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Phosphorylation Developmental Process Immune Response-regulating Signaling Pathway Signaling Neurogenesis Cell Communication Cell Migration Signal Transduction Regulation Of Phosphorus Metabolic Process Axon Guidance Cell Activation Movement Of Cell Or Subcellular Component Cell Morphogenesis Involved In Differentiation Cell Development Cell Surface Receptor Signaling Pathway Cell Motility Neuron Differentiation Cell Projection Organization Cellular Response To Organonitrogen Compound Neuron Development Chemotaxis Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Regulation Of Kinase Activity Ephrin Receptor Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Nervous System Development Organ Development Neuron Projection Development Cell Differentiation Regulation Of Cell-cell Adhesion
Tagcloud ?			10kb appbp2 bcas3 breakpoints ccdc49 coamplification col14a1 coregulator ddx5 depdc6 deptor enpp2 hoxb9 lasp1 leukaemias nrip1 oprd1 painting pcgf2 phf20l1 plec1 skap1 taok1 tiam1 timm23 trps1 unamplified usp32 zmym4
Tagcloud (Difference) ?			10kb appbp2 bcas3 breakpoints ccdc49 coamplification col14a1 coregulator ddx5 depdc6 deptor enpp2 hoxb9 lasp1 leukaemias nrip1 oprd1 painting pcgf2 phf20l1 plec1 skap1 taok1 tiam1 timm23 trps1 unamplified usp32 zmym4
Tagcloud (Intersection) ?