GLIS2 and CPSF1

Number of citations of the paper that reports this interaction (PubMedID 17289029)
20

Data Source:
BioGRID (two hybrid)

		GLIS2	CPSF1
Description		GLIS family zinc finger 2	cleavage and polyadenylation specific factor 1
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Nuclear Speck Non-motile Cilium	Nucleus Nucleoplasm MRNA Cleavage And Polyadenylation Specificity Factor Complex
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Protein Binding Zinc Ion Binding Metal Ion Binding Sequence-specific Double-stranded DNA Binding	Nucleic Acid Binding RNA Binding Protein Binding Enzyme Binding MRNA 3'-UTR AU-rich Region Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Kidney Development Regulation Of Transcription By RNA Polymerase II Nervous System Development Central Nervous System Development Cell Differentiation Negative Regulation Of Smoothened Signaling Pathway Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Cell Differentiation Involved In Kidney Development Hematopoietic Stem Cell Homeostasis Positive Regulation Of Protein Localization To Nucleus	MRNA Processing RNA 3'-end Processing Co-transcriptional RNA 3'-end Processing, Cleavage And Polyadenylation Pathway
Pathways			Transport of Mature mRNA Derived from an Intronless Transcript tRNA processing in the nucleus mRNA 3'-end processing Processing of Capped Intron-Containing Pre-mRNA RNA Polymerase II Transcription Termination Processing of Intronless Pre-mRNAs
Drugs
Diseases		Nephronophthisis-medullary cystic kidney disease, including; Nephronophthisis (NPH) ; Nephronophthisis-like nephropathy 1; Medullary cystic kidney disease 1; Medullary cystic kidney disease 2 (MSKD2)
GWAS		Erectile dysfunction ( 30583798) Femur bone mineral density x serum urate levels interaction ( 34046847) Heel bone mineral density ( 30598549) Hip circumference adjusted for BMI ( 34021172) Hip index ( 34021172) Liver enzyme levels (alkaline phosphatase) ( 33972514) Lung function (FEV1/FVC) ( 26635082) Prostate-specific antigen levels ( 28139693) Waist-to-hip ratio adjusted for BMI ( 34021172)	Educational attainment ( 25201988)
Interacting Genes		92 interacting genes: ACTMAP ACTN3 AKAP9 AKT1 ANKRD36B ARAF ARID5A ARNT BCAR1 BECN1 CBLC CCND2 CCNE1 CD44 CDK4 CDK6 CDKN2A CDKN2B CPSF1 CREM CRX CSNK2B CTBP2 CTNNB1 EPHA2 ERBB2 FAM168B FGFR4 FOSB FZR1 GLIS1 GMNN GOLGA6L9 GPSM1 GPSM2 HGF HIF1A KRTAP19-3 KRTAP19-5 KRTAP19-7 KRTAP6-1 KRTAP6-2 KRTAP8-1 LATS2 MAP2K3 MAP2K5 MAP2K6 MAP3K5 MDM2 MDM4 MET MYC NF2 NFIC NME7 NSD3 OIP5 PIK3CA PLEKHB1 PLEKHB2 POU6F2 PRKAR1B PRR20A PRR20B PRR20C PRR20D PRR20E RAF1 RASSF1 RBFOX2 RBM11 RBPMS SHOX SOX3 SPECC1L STK11 TEAD2 TENT5A TERT TLE5 TRIM32 TSC1 TWIST2 U2AF2 VAC14 VBP1 VENTX WNK1 WT1 WWOX XAB2 ZRANB1	58 interacting genes: CSTF2T GLIS2 HMOX1 IL7R INCA1 MCM2 MIR1-2 MIR106B MIR107 MIR122 MIR128-2 MIR138-1 MIR138-2 MIR143 MIR155 MIR15A MIR15B MIR16-2 MIR18A MIR18B MIR199A1 MIR199A2 MIR19A MIR19B1 MIR19B2 MIR200C MIR205 MIR206 MIR20B MIR21 MIR214 MIR221 MIR29A MIR31 MIR34A MIR34B MIR7-1 MIR92A1 MIR92A2 MIR98 MIRLET7A3 MIRLET7B MIRLET7C MIRLET7E MIRLET7F2 MIRLET7G MIRLET7I NEDD4 PAPOLA POLR2A PRRC2A REL TAF11 TAF12 TAF13 TAF5 TAF7 UBC
Entrez ID		84662	29894
HPRD ID		12256	05823
Ensembl ID		ENSG00000126603	ENSG00000071894
Uniprot IDs		B3KTH4 Q9BZE0	Q10570
PDB IDs			6BLY 6BM0 6DNH 6F9N 6FUW 6URG 6URO 8E3I 8E3Q 8R8R
Enriched GO Terms of Interacting Partners?		Regulation Of Metabolic Process Negative Regulation Of Metabolic Process Positive Regulation Of RNA Biosynthetic Process Kinase Activity Positive Regulation Of DNA-templated Transcription Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Primary Metabolic Process Response To Growth Factor Protein Kinase Activity Regulation Of Cell Cycle Regulation Of RNA Metabolic Process Regulation Of Cell Population Proliferation Regulation Of Macromolecule Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Programmed Cell Death Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Metabolic Process Positive Regulation Of Signal Transduction Regulation Of DNA-templated Transcription Positive Regulation Of Macromolecule Metabolic Process Regulation Of RNA Biosynthetic Process Regulation Of Apoptotic Process Protein Binding Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Intracellular Signal Transduction Intracellular Signal Transduction Protein Serine/threonine Kinase Activity Signal Transduction Positive Regulation Of Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Protein Serine Kinase Activity Positive Regulation Of Cell Communication Positive Regulation Of Signaling Negative Regulation Of Programmed Cell Death Regulation Of Gene Expression Negative Regulation Of RNA Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Protein Kinase Binding Developmental Process Negative Regulation Of Apoptotic Process Regulation Of Apoptotic Signaling Pathway Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II Cell Differentiation Cellular Response To Growth Factor Stimulus Regulation Of Signal Transduction Animal Organ Development MAPK Cascade Negative Regulation Of Apoptotic Signaling Pathway Negative Regulation Of Intracellular Signal Transduction	RISC Complex MiRNA-mediated Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Post-transcriptional Gene Silencing Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Gene Silencing MRNA Base-pairing Post-transcriptional Repressor Activity Post-transcriptional Regulation Of Gene Expression Negative Regulation Of Gene Expression MRNA 3'-UTR Binding Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process MiRNA-mediated Gene Silencing By Inhibition Of Translation Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process Extracellular Vesicle MiRNA-mediated Gene Silencing By MRNA Destabilization Regulation Of Angiogenesis Regulation Of Gene Expression Regulation Of Vasculature Development Negative Regulation Of Cytokine Production Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process Negative Regulation Of Angiogenesis Negative Regulation Of Vasculature Development Regulation Of Metabolic Process Negative Regulation Of Cell Migration Negative Regulation Of Translation Negative Regulation Of Cell Motility Negative Regulation Of Locomotion MRNA Destabilization RNA Destabilization Positive Regulation Of MRNA Catabolic Process Regulation Of Endothelial Cell Migration Negative Regulation Of Multicellular Organismal Process Regulation Of Blood Vessel Endothelial Cell Migration Negative Regulation Of Endothelial Cell Migration Positive Regulation Of MRNA Metabolic Process Negative Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of Cytokine Production Negative Regulation Of Vascular Endothelial Growth Factor Production Regulation Of Anatomical Structure Morphogenesis Negative Regulation Of Protein Metabolic Process Regulation Of MRNA Stability Negative Regulation Of Signal Transduction Regulation Of Endothelial Cell Proliferation Regulation Of Cell Migration Involved In Sprouting Angiogenesis Regulation Of RNA Stability Extracellular Space Regulation Of Translation Negative Regulation Of Cell Communication
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