GLIS2 and KRTAP19-7

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		GLIS2	KRTAP19-7
Description		GLIS family zinc finger 2	keratin associated protein 19-7
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Nuclear Speck Non-motile Cilium	Cytosol Intermediate Filament
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Protein Binding Zinc Ion Binding Metal Ion Binding Sequence-specific Double-stranded DNA Binding	Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Kidney Development Regulation Of Transcription By RNA Polymerase II Nervous System Development Central Nervous System Development Cell Differentiation Negative Regulation Of Smoothened Signaling Pathway Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Cell Differentiation Involved In Kidney Development Hematopoietic Stem Cell Homeostasis Positive Regulation Of Protein Localization To Nucleus
Pathways			Keratinization
Drugs
Diseases		Nephronophthisis-medullary cystic kidney disease, including; Nephronophthisis (NPH) ; Nephronophthisis-like nephropathy 1; Medullary cystic kidney disease 1; Medullary cystic kidney disease 2 (MSKD2)
GWAS		Erectile dysfunction ( 30583798) Femur bone mineral density x serum urate levels interaction ( 34046847) Heel bone mineral density ( 30598549) Hip circumference adjusted for BMI ( 34021172) Hip index ( 34021172) Liver enzyme levels (alkaline phosphatase) ( 33972514) Lung function (FEV1/FVC) ( 26635082) Prostate-specific antigen levels ( 28139693) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		92 interacting genes: ACTMAP ACTN3 AKAP9 AKT1 ANKRD36B ARAF ARID5A ARNT BCAR1 BECN1 CBLC CCND2 CCNE1 CD44 CDK4 CDK6 CDKN2A CDKN2B CPSF1 CREM CRX CSNK2B CTBP2 CTNNB1 EPHA2 ERBB2 FAM168B FGFR4 FOSB FZR1 GLIS1 GMNN GOLGA6L9 GPSM1 GPSM2 HGF HIF1A KRTAP19-3 KRTAP19-5 KRTAP19-7 KRTAP6-1 KRTAP6-2 KRTAP8-1 LATS2 MAP2K3 MAP2K5 MAP2K6 MAP3K5 MDM2 MDM4 MET MYC NF2 NFIC NME7 NSD3 OIP5 PIK3CA PLEKHB1 PLEKHB2 POU6F2 PRKAR1B PRR20A PRR20B PRR20C PRR20D PRR20E RAF1 RASSF1 RBFOX2 RBM11 RBPMS SHOX SOX3 SPECC1L STK11 TEAD2 TENT5A TERT TLE5 TRIM32 TSC1 TWIST2 U2AF2 VAC14 VBP1 VENTX WNK1 WT1 WWOX XAB2 ZRANB1	83 interacting genes: ANKS1A ARID5A ARMC7 ATPAF2 ATXN1L BAHD1 BHLHE40 C11orf16 CAMK2A CAMK2B CATSPER1 CCDC24 CCNK COL8A1 CYSRT1 DAB1 DAZAP2 DTX2 EVX2 FAM168A FOXD2 FOXH1 FOXI1 GLIS2 GNE GSX1 HOMER3 HOXA1 HSF4 IRX6 KPRP KRT34 KRTAP10-8 KRTAP12-3 KRTAP12-4 KRTAP26-1 KRTAP3-3 KRTAP6-3 KRTAP9-2 LONRF1 MAPK1IP1L MGAT5B MKRN3 NAF1 NEU4 NOTO NOXA1 OTX1 PATZ1 PAX7 PITX1 PITX2 PLSCR3 PLSCR4 POU2AF1 POU4F2 PROP1 PRR13 PSMB1 PSMB2 RBPMS RBPMS2 RHOXF2 RNF44 ROR2 SMN1 SMN2 SPAG8 SPMIP9 TCAP TCF7L2 TEKT5 TFAP2D TLE5 TLX3 TNIP1 TOLLIP TPRX1 VAC14 VENTX VGLL3 VPS37C ZIC1
Entrez ID		84662	337974
HPRD ID		12256	11211
Ensembl ID		ENSG00000126603	ENSG00000244362
Uniprot IDs		B3KTH4 Q9BZE0	Q3SYF9
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Metabolic Process Negative Regulation Of Metabolic Process Positive Regulation Of RNA Biosynthetic Process Kinase Activity Positive Regulation Of DNA-templated Transcription Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Primary Metabolic Process Response To Growth Factor Protein Kinase Activity Regulation Of Cell Cycle Regulation Of RNA Metabolic Process Regulation Of Cell Population Proliferation Regulation Of Macromolecule Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Programmed Cell Death Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Metabolic Process Positive Regulation Of Signal Transduction Regulation Of DNA-templated Transcription Positive Regulation Of Macromolecule Metabolic Process Regulation Of RNA Biosynthetic Process Regulation Of Apoptotic Process Protein Binding Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Intracellular Signal Transduction Intracellular Signal Transduction Protein Serine/threonine Kinase Activity Signal Transduction Positive Regulation Of Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Protein Serine Kinase Activity Positive Regulation Of Cell Communication Positive Regulation Of Signaling Negative Regulation Of Programmed Cell Death Regulation Of Gene Expression Negative Regulation Of RNA Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Protein Kinase Binding Developmental Process Negative Regulation Of Apoptotic Process Regulation Of Apoptotic Signaling Pathway Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II Cell Differentiation Cellular Response To Growth Factor Stimulus Regulation Of Signal Transduction Animal Organ Development MAPK Cascade Negative Regulation Of Apoptotic Signaling Pathway Negative Regulation Of Intracellular Signal Transduction	Sequence-specific Double-stranded DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Chromatin Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of RNA Metabolic Process Regulation Of RNA Biosynthetic Process DNA-binding Transcription Activator Activity, RNA Polymerase II-specific RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Protein Binding Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Nucleobase-containing Compound Metabolic Process DNA-binding Transcription Factor Activity Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process DNA Binding Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Metabolic Process Intermediate Filament Sequence-specific DNA Binding Keratin Filament Identical Protein Binding Nucleus Cellular Developmental Process Cell Differentiation Regulation Of Gene Expression Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Developmental Process Regionalization Myoblast Fate Commitment Regulation Of Macromolecule Biosynthetic Process Central Nervous System Development Positive Regulation Of Biosynthetic Process Pattern Specification Process Somatotropin Secreting Cell Differentiation Anatomical Structure Morphogenesis Transcription Regulator Complex Axonemal A Tubule Inner Sheath Embryonic Morphogenesis Calcium- And Calmodulin-dependent Protein Kinase Complex Positive Regulation Of Macromolecule Metabolic Process Transcription Cis-regulatory Region Binding Regulation Of Macromolecule Metabolic Process DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Neuron Differentiation System Development Pituitary Gland Development Muscle Tissue Morphogenesis Adenohypophysis Development
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