GLIS2 and PLEKHB1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		GLIS2	PLEKHB1
Description		GLIS family zinc finger 2	pleckstrin homology domain containing B1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Nuclear Speck Non-motile Cilium	Cytoplasm Membrane
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Protein Binding Zinc Ion Binding Metal Ion Binding Sequence-specific Double-stranded DNA Binding	Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Kidney Development Regulation Of Transcription By RNA Polymerase II Nervous System Development Central Nervous System Development Cell Differentiation Negative Regulation Of Smoothened Signaling Pathway Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Cell Differentiation Involved In Kidney Development Hematopoietic Stem Cell Homeostasis Positive Regulation Of Protein Localization To Nucleus	Phototransduction Regulation Of Cell Differentiation
Pathways
Drugs
Diseases		Nephronophthisis-medullary cystic kidney disease, including; Nephronophthisis (NPH) ; Nephronophthisis-like nephropathy 1; Medullary cystic kidney disease 1; Medullary cystic kidney disease 2 (MSKD2)
GWAS		Erectile dysfunction ( 30583798) Femur bone mineral density x serum urate levels interaction ( 34046847) Heel bone mineral density ( 30598549) Hip circumference adjusted for BMI ( 34021172) Hip index ( 34021172) Liver enzyme levels (alkaline phosphatase) ( 33972514) Lung function (FEV1/FVC) ( 26635082) Prostate-specific antigen levels ( 28139693) Waist-to-hip ratio adjusted for BMI ( 34021172)	Dimensional psychopathology (Cognitive) ( 29496196) Glucose homeostasis traits ( 25524916) Hand grip strength ( 27325353) Smoking status (ever vs never smokers) ( 30643258)
Interacting Genes		92 interacting genes: ACTMAP ACTN3 AKAP9 AKT1 ANKRD36B ARAF ARID5A ARNT BCAR1 BECN1 CBLC CCND2 CCNE1 CD44 CDK4 CDK6 CDKN2A CDKN2B CPSF1 CREM CRX CSNK2B CTBP2 CTNNB1 EPHA2 ERBB2 FAM168B FGFR4 FOSB FZR1 GLIS1 GMNN GOLGA6L9 GPSM1 GPSM2 HGF HIF1A KRTAP19-3 KRTAP19-5 KRTAP19-7 KRTAP6-1 KRTAP6-2 KRTAP8-1 LATS2 MAP2K3 MAP2K5 MAP2K6 MAP3K5 MDM2 MDM4 MET MYC NF2 NFIC NME7 NSD3 OIP5 PIK3CA PLEKHB1 PLEKHB2 POU6F2 PRKAR1B PRR20A PRR20B PRR20C PRR20D PRR20E RAF1 RASSF1 RBFOX2 RBM11 RBPMS SHOX SOX3 SPECC1L STK11 TEAD2 TENT5A TERT TLE5 TRIM32 TSC1 TWIST2 U2AF2 VAC14 VBP1 VENTX WNK1 WT1 WWOX XAB2 ZRANB1	18 interacting genes: ACVR1 ATXN1 BAG3 BMPR1B BTG3 C10orf55 CCR8 DSCR9 GLIS2 GNGT1 LCOR RAP1GDS1 RBM11 RUNX1 SMAD1 TGFBR1 VENTX ZDHHC17
Entrez ID		84662	58473
HPRD ID		12256	09630
Ensembl ID		ENSG00000126603	ENSG00000021300
Uniprot IDs		B3KTH4 Q9BZE0	Q9UF11
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Metabolic Process Negative Regulation Of Metabolic Process Positive Regulation Of RNA Biosynthetic Process Kinase Activity Positive Regulation Of DNA-templated Transcription Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Primary Metabolic Process Response To Growth Factor Protein Kinase Activity Regulation Of Cell Cycle Regulation Of RNA Metabolic Process Regulation Of Cell Population Proliferation Regulation Of Macromolecule Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Programmed Cell Death Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Metabolic Process Positive Regulation Of Signal Transduction Regulation Of DNA-templated Transcription Positive Regulation Of Macromolecule Metabolic Process Regulation Of RNA Biosynthetic Process Regulation Of Apoptotic Process Protein Binding Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Intracellular Signal Transduction Intracellular Signal Transduction Protein Serine/threonine Kinase Activity Signal Transduction Positive Regulation Of Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Protein Serine Kinase Activity Positive Regulation Of Cell Communication Positive Regulation Of Signaling Negative Regulation Of Programmed Cell Death Regulation Of Gene Expression Negative Regulation Of RNA Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Protein Kinase Binding Developmental Process Negative Regulation Of Apoptotic Process Regulation Of Apoptotic Signaling Pathway Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II Cell Differentiation Cellular Response To Growth Factor Stimulus Regulation Of Signal Transduction Animal Organ Development MAPK Cascade Negative Regulation Of Apoptotic Signaling Pathway Negative Regulation Of Intracellular Signal Transduction	Transforming Growth Factor Beta Receptor Activity, Type I Transmembrane Receptor Protein Serine/threonine Kinase Activity Activin Receptor Complex Activin Receptor Activity, Type I SMAD Binding Positive Regulation Of Cardiac Epithelial To Mesenchymal Transition Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway BMP Receptor Activity Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Positive Regulation Of Osteoblast Differentiation Activin Binding Regulation Of Cartilage Development BMP Signaling Pathway Striated Muscle Cell Apoptotic Process Cellular Response To Growth Factor Stimulus Pharyngeal System Development Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Transcription By RNA Polymerase II Muscle Cell Apoptotic Process I-SMAD Binding Positive Regulation Of Cell Differentiation Transforming Growth Factor Beta Binding Poly(U) RNA Binding Positive Regulation Of RNA Metabolic Process Response To Growth Factor Osteoblast Differentiation Positive Regulation Of Extracellular Matrix Organization Enzyme-linked Receptor Protein Signaling Pathway Regulation Of Osteoblast Differentiation Activin Receptor Signaling Pathway Cellular Response To BMP Stimulus Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Cartilage Development Regulation Of Extrinsic Apoptotic Signaling Pathway Pattern Specification Process Ventricular Septum Morphogenesis Regulation Of RNA Metabolic Process Positive Regulation Of SMAD Protein Signal Transduction Positive Regulation Of Bone Mineralization Cell Fate Commitment Positive Regulation Of Vasculature Development Regulation Of Cardiac Muscle Cell Proliferation DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Growth Factor Binding Endocardial Cushion Cell Fate Commitment CAAX-box Protein Maturation Perforant Pathway To Dendrate Granule Cell Synapse Cellular Developmental Process
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