TTF2 and SKIL

Number of citations of the paper that reports this interaction (PMID 15231748)
65

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		TTF2	SKIL
Gene Name		transcription termination factor, RNA polymerase II	SKI-like proto-oncogene
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Spliceosomal Complex Cytoplasm Transcription Elongation Factor Complex	Acrosomal Vesicle Nucleus Nucleoplasm Cytoplasm PML Body Protein Complex
	Molecular Function	DNA Binding Protein Binding ATP Binding ATP-dependent Helicase Activity DNA-dependent ATPase Activity Zinc Ion Binding	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Negative Regulation Of Transcription DNA Binding Chromatin Binding Transcription Corepressor Activity Protein Binding Protein Domain Specific Binding Protein Complex Binding SMAD Binding
	Biological Process	DNA-templated Transcription, Termination Regulation Of Transcription, DNA-templated Termination Of RNA Polymerase II Transcription MRNA Processing RNA Splicing	Negative Regulation Of Transcription From RNA Polymerase II Promoter Blastocyst Formation Lymphocyte Homeostasis Transcription, DNA-templated Transcription Initiation From RNA Polymerase II Promoter Cell Cycle Arrest Transforming Growth Factor Beta Receptor Signaling Pathway Spermatogenesis Skeletal Muscle Tissue Development Gene Expression Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Response To Cytokine Regulation Of Apoptotic Process Negative Regulation Of Cell Differentiation Response To Antibiotic Positive Regulation Of Axonogenesis Protein Homotrimerization Protein Heterotrimerization Lens Fiber Cell Differentiation Response To Growth Factor Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Positive Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Pathways			Loss of Function of TGFBR2 in Cancer TGFBR2 MSI Frameshift Mutants in Cancer SMAD2/3 Phosphorylation Motif Mutants in Cancer Loss of Function of SMAD2/3 in Cancer TGFBR2 Kinase Domain Mutants in Cancer Loss of Function of SMAD4 in Cancer SMAD2/3 MH2 Domain Mutants in Cancer TGFBR1 KD Mutants in Cancer Downregulation of SMAD2/3:SMAD4 transcriptional activity TGFBR1 LBD Mutants in Cancer Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer Loss of Function of TGFBR1 in Cancer Generic Transcription Pathway Signaling by TGF-beta Receptor Complex Signaling by TGF-beta Receptor Complex in Cancer SMAD4 MH2 Domain Mutants in Cancer
Drugs
Diseases
GWAS			Prostate cancer ( 21743467)
Protein-Protein Interactions		22 interactors: CDC5L CDKL3 CLPB DCP1A DR1 DRAP1 HINFP HNRNPA1 HNRNPA2B1 KIF4A MATR3 MYB MYBL2 NVL PDCD6IP PRDX4 SKIL SMAD1 SMAD7 TACC3 TNIP1 ZSCAN1	90 interactors: AES ASCC3 C12orf10 CAMSAP1 CBX4 CDC16 CDC27 CHD3 CHPF COL4A2 CPNE1 CPNE2 CPNE4 CXXC5 DHX30 DRG1 EEF1G EIF4G2 ESR1 FAF1 FBLN1 FN1 FZR1 GLUL GOLGB1 HEY1 HEYL HIPK1 HIPK3 IL36RN KRT81 LRP1 MACF1 MORC4 MVP NCOR1 NCOR2 NID1 NID2 NXF3 OIP5 PAPPA PIAS1 PIAS3 PIAS4 PLCD3 PPL PSG3 PSMC2 PTPRF PYCR2 RNF4 RPS27 SASH1 SETDB1 SKI SMAD1 SMAD2 SMAD3 SMAD4 SMURF2 SNRNP70 SNX17 SPARCL1 SRP72 STK16 SVEP1 TDG TDP2 TFPI2 THAP5 THSD7A TPM2 TRAK1 TRIM62 TRIM69 TSKU TTF2 UBE2I UIMC1 USP25 VPS28 XRCC6 ZBTB3 ZBTB6 ZMYM2 ZMYM5 ZNF106 ZNF200 ZZEF1
Entrez ID		8458	6498
HPRD ID		05280	01319
Ensembl ID			ENSG00000136603
Uniprot IDs		Q9UNY4	P12757
PDB IDs			3EQ5
Enriched GO Terms of Interacting Partners?		Gene Expression Regulation Of Transcription From RNA Polymerase II Promoter RNA Metabolic Process Heterocycle Metabolic Process Transcription, DNA-templated Negative Regulation Of Gene Expression RNA Biosynthetic Process Nucleobase-containing Compound Metabolic Process Nitrogen Compound Metabolic Process Cell Cycle Process Cellular Aromatic Compound Metabolic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Cellular Macromolecule Biosynthetic Process Regulation Of RNA Metabolic Process Macromolecule Biosynthetic Process Transcription From RNA Polymerase II Promoter Negative Regulation Of Biosynthetic Process Cell Cycle Regulation Of Cell Cycle Regulation Of Gene Expression Cellular Metabolic Process Mitotic Spindle Assembly Regulation Of Nitrogen Compound Metabolic Process Spindle Organization Negative Regulation Of Cellular Metabolic Process Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Cell Morphogenesis Involved In Differentiation Positive Regulation Of Dendrite Morphogenesis Cellular Response To Transforming Growth Factor Beta Stimulus Response To Transforming Growth Factor Beta Positive Regulation Of Transcription, DNA-templated Regulation Of Cell Morphogenesis Biosynthetic Process Mitotic Spindle Organization Positive Regulation Of Neuron Projection Development MRNA Metabolic Process MRNA Splicing, Via Spliceosome Negative Regulation Of Male Germ Cell Proliferation Modulation By Symbiont Of Host I-kappaB Kinase/NF-kappaB Cascade Response To Stress RNA Splicing, Via Transesterification Reactions Positive Regulation Of Dendrite Development Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway	Gene Expression RNA Biosynthetic Process Transcription, DNA-templated Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process RNA Metabolic Process Negative Regulation Of Cellular Metabolic Process Negative Regulation Of RNA Biosynthetic Process Cellular Response To Transforming Growth Factor Beta Stimulus Negative Regulation Of Gene Expression Response To Transforming Growth Factor Beta Negative Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Nucleic Acid-templated Transcription Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Regulation Of Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter SMAD Protein Complex Assembly Transforming Growth Factor Beta Receptor Signaling Pathway Protein Modification By Small Protein Conjugation Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Nitrogen Compound Metabolic Process Protein Sumoylation Nitrogen Compound Metabolic Process Cellular Metabolic Process Cellular Aromatic Compound Metabolic Process Transcription Initiation From RNA Polymerase II Promoter Regulation Of RNA Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Cellular Process Regulation Of Gene Expression Regulation Of Transcription, DNA-templated Primary MiRNA Processing Cell Proliferation Positive Regulation Of Cellular Metabolic Process Protein K11-linked Ubiquitination DNA-templated Transcription, Initiation Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Transcription From RNA Polymerase II Promoter Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Signaling Regulation Of Binding Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Signaling Gastrulation Proteasomal Protein Catabolic Process
Tagcloud ?		away bidirectional coimmunoprecipitate cotranscriptional dcp1a dcp2 decapping edc3 elongation ends exonuclease facilitates localize nascent pause paused peaks pol premature productive redistribution seq shifted spt5 termination torpedo tss tsss xrn2	applying associations assuming atm axin1 conserving deleterious endpoints ep300 ercc2 erythema exception gstp1 individually lig4 nos3 nqo1 radiosensitivity snp snps sod2 tgfb tgfb1 unravel weighted xdh xrcc1 xrcc3 xrcc6
Tagcloud (Difference) ?		away bidirectional coimmunoprecipitate cotranscriptional dcp1a dcp2 decapping edc3 elongation ends exonuclease facilitates localize nascent pause paused peaks pol premature productive redistribution seq shifted spt5 termination torpedo tss tsss xrn2	applying associations assuming atm axin1 conserving deleterious endpoints ep300 ercc2 erythema exception gstp1 individually lig4 nos3 nqo1 radiosensitivity snp snps sod2 tgfb tgfb1 unravel weighted xdh xrcc1 xrcc3 xrcc6
Tagcloud (Intersection) ?