TTF2 and NVL

Number of citations of the paper that reports this interaction (PubMedID 12927788)
0

Data Source:
BioGRID (two hybrid)

		TTF2	NVL
Description		transcription termination factor 2	nuclear VCP like
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Spliceosomal Complex Cytoplasm Cytosol Transcription Elongation Factor Complex	Nuclear Exosome (RNase Complex) Nucleus Nucleoplasm Telomerase Holoenzyme Complex Nucleolus Membrane
	Molecular Function	Nucleotide Binding DNA Binding Helicase Activity Protein Binding ATP Binding ATP-dependent Activity, Acting On DNA Zinc Ion Binding Hydrolase Activity Metal Ion Binding	Nucleotide Binding RNA Binding Protein Binding ATP Binding ATP Hydrolysis Activity Protein-containing Complex Binding Preribosome Binding
	Biological Process	DNA Repair DNA-templated Transcription Termination Termination Of RNA Polymerase II Transcription MRNA Processing RNA Splicing	RRNA Processing Positive Regulation Of Protein Binding Positive Regulation Of Telomere Maintenance Ribosome Biogenesis Ribosomal Large Subunit Biogenesis Regulation Of Protein Localization To Nucleolus Telomerase Holoenzyme Complex Assembly
Pathways
Drugs
Diseases
GWAS			HDL cholesterol levels in HIV infection ( 33109212) Major depressive disorder ( 21042317) Mean corpuscular hemoglobin ( 32888494)
Interacting Genes		27 interacting genes: CDC5L CDKL3 CEBPA CLPB DCP1A DRAP1 FZR1 GMEB2 HINFP HNRNPA1 HNRNPA2B1 KIF4A LINC01554 MATR3 MYB MYBL2 NVL PDCD6IP PRDX4 SKIL SMAD1 SMAD7 TACC3 TCF4 TNIP1 UBC ZSCAN1	11 interacting genes: ADARB1 CRMP1 FBXO7 HSPB1 LINC00839 OSGEP RNF10 RNF4 RPL5 TTF2 UBE2I
Entrez ID		8458	4931
HPRD ID		05280	03887
Ensembl ID		ENSG00000116830	ENSG00000143748
Uniprot IDs		Q9UNY4	B4DF43 O15381
PDB IDs			2X8A 6RO1
Enriched GO Terms of Interacting Partners?		Nucleus Identical Protein Binding Nuclear Matrix DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity, RNA Polymerase II-specific RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Regulation Of Nucleobase-containing Compound Metabolic Process RNA Metabolic Process WD40-repeat Domain Binding DNA Binding Regulation Of Transcription By RNA Polymerase II Transcription Regulator Complex MiRNA Binding Regulation Of Macromolecule Metabolic Process Heteromeric SMAD Protein Complex G-rich Strand Telomeric DNA Binding Positive Regulation Of Nucleobase-containing Compound Metabolic Process Nucleic Acid Metabolic Process Regulation Of Cell Cycle Regulation Of Metabolic Process Primary MiRNA Processing Regulation Of Primary Metabolic Process Positive Regulation Of Telomere Maintenance Regulation Of RNA Metabolic Process Nucleoplasm Lens Fiber Cell Differentiation Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process I-SMAD Binding Positive Regulation Of Cell Differentiation Catalytic Step 2 Spliceosome Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Response To Stress Regulation Of RNA Biosynthetic Process Protein Domain Specific Binding Mitotic Spindle Organization Regulation Of Gene Expression Positive Regulation Of Transcription By RNA Polymerase II DNA Damage Checkpoint Signaling DNA-templated Transcription Negative Regulation Of Cell Differentiation Regulation Of Chromosome Organization Transforming Growth Factor Beta Receptor Signaling Pathway Cellular Response To Leukemia Inhibitory Factor Blastocyst Formation Response To Leukemia Inhibitory Factor Positive Regulation Of Chromosome Organization Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Telomere Maintenance	Hypoglossal Nerve Morphogenesis Negative Regulation Of Protein Kinase C Signaling Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Modification-dependent Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process SUMO Conjugating Enzyme Activity Glial Cytoplasmic Inclusion Classical Lewy Body Lewy Body Corona Lewy Neurite Proteolysis Involved In Protein Catabolic Process Protein Modification By Small Protein Conjugation Protein Autoubiquitination Negative Regulation Of Protein Kinase Activity By Regulation Of Protein Phosphorylation Double-stranded RNA Adenosine Deaminase Activity Cytoplasm Adenosine To Inosine Editing RNA Processing Spinal Cord Ventral Commissure Morphogenesis Facial Nerve Morphogenesis Cytosol Regulation Of Protein Kinase C Signaling Unfolded Protein Binding Negative Regulation Of Intrinsic Apoptotic Signaling Pathway Protein Kinase C Inhibitor Activity Ubiquitin Binding Regulation Of Kinetochore Assembly Post-translational Protein Modification Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process SUMO Polymer Binding Protein K48-linked Ubiquitination PML Body Cytosolic Ribosome Negative Regulation Of Protein Neddylation RING-like Zinc Finger Domain Binding SUMO Ligase Complex Small Protein Activating Enzyme Binding HLH Domain Binding Postsynapse To Nucleus Signaling Pathway Extrinsic Component Of Postsynaptic Density Membrane Lewy Body Core EKC/KEOPS Complex TRNA N(6)-L-threonylcarbamoyladenine Synthase Activity TRNA Threonylcarbamoyladenosine Modification TRNA-specific Adenosine Deaminase Activity Dihydropyrimidinase Activity Regulation Of Centromere Complex Assembly Proteasomal Protein Catabolic Process Negative Regulation Of Protein Localization To Chromatin
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