TTF2 and TACC3

Number of citations of the paper that reports this interaction (PubMedID 12927788)
0

Data Source:
HPRD (two hybrid)

		TTF2	TACC3
Description		transcription termination factor 2	transforming acidic coiled-coil containing protein 3
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Spliceosomal Complex Cytoplasm Cytosol Transcription Elongation Factor Complex	Spindle Pole Cytoplasm Golgi Apparatus Centrosome Spindle Cytosol Cytoskeleton Centriolar Satellite Ciliary Basal Body Mitotic Spindle
	Molecular Function	Nucleotide Binding DNA Binding Helicase Activity Protein Binding ATP Binding ATP-dependent Activity, Acting On DNA Zinc Ion Binding Hydrolase Activity Metal Ion Binding	Protein Binding
	Biological Process	DNA Repair DNA-templated Transcription Termination Termination Of RNA Polymerase II Transcription MRNA Processing RNA Splicing	Microtubule Cytoskeleton Organization Mitotic Spindle Organization Metaphase/anaphase Transition Of Mitotic Cell Cycle Nuclear Migration Cerebral Cortex Development Cell Division Regulation Of Mitotic Spindle Organization Microtubule Cytoskeleton Organization Involved In Mitosis
Pathways			NOTCH3 Activation and Transmission of Signal to the Nucleus Negative regulation of NOTCH4 signaling
Drugs
Diseases
GWAS			Appendicular lean mass ( 33097823) Bladder cancer ( 20972438 24163127) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Hip circumference adjusted for BMI ( 34021172) Mean spheric corpuscular volume ( 32888494) Subcortical volume (MOSTest) ( 32665545) Urinary bladder cancer ( 20348956)
Interacting Genes		27 interacting genes: CDC5L CDKL3 CEBPA CLPB DCP1A DRAP1 FZR1 GMEB2 HINFP HNRNPA1 HNRNPA2B1 KIF4A LINC01554 MATR3 MYB MYBL2 NVL PDCD6IP PRDX4 SKIL SMAD1 SMAD7 TACC3 TCF4 TNIP1 UBC ZSCAN1	30 interacting genes: AKAP9 ARHGDIG ARNT ARNT2 ASPSCR1 AURKA BEX2 BEX3 CATSPERT CCHCR1 CDC20B CDKL5 CIB3 CLIP4 DRC10 EIF3C GDF15 KAT2A KIZ KLC1 KLHL38 NDEL1 NOD2 NUP54 RNF20 SNX20 SPATA18 TBC1D22B TTF2 VPS37C
Entrez ID		8458	10460
HPRD ID		05280	05601
Ensembl ID		ENSG00000116830	ENSG00000013810
Uniprot IDs		Q9UNY4	A0A087WUE2 Q9Y6A5
PDB IDs			5LXN 5LXO 5ODS 5ODT
Enriched GO Terms of Interacting Partners?		Nucleus Identical Protein Binding Nuclear Matrix DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity, RNA Polymerase II-specific RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Regulation Of Nucleobase-containing Compound Metabolic Process RNA Metabolic Process WD40-repeat Domain Binding DNA Binding Regulation Of Transcription By RNA Polymerase II Transcription Regulator Complex MiRNA Binding Regulation Of Macromolecule Metabolic Process Heteromeric SMAD Protein Complex G-rich Strand Telomeric DNA Binding Positive Regulation Of Nucleobase-containing Compound Metabolic Process Nucleic Acid Metabolic Process Regulation Of Cell Cycle Regulation Of Metabolic Process Primary MiRNA Processing Regulation Of Primary Metabolic Process Positive Regulation Of Telomere Maintenance Regulation Of RNA Metabolic Process Nucleoplasm Lens Fiber Cell Differentiation Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process I-SMAD Binding Positive Regulation Of Cell Differentiation Catalytic Step 2 Spliceosome Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Response To Stress Regulation Of RNA Biosynthetic Process Protein Domain Specific Binding Mitotic Spindle Organization Regulation Of Gene Expression Positive Regulation Of Transcription By RNA Polymerase II DNA Damage Checkpoint Signaling DNA-templated Transcription Negative Regulation Of Cell Differentiation Regulation Of Chromosome Organization Transforming Growth Factor Beta Receptor Signaling Pathway Cellular Response To Leukemia Inhibitory Factor Blastocyst Formation Response To Leukemia Inhibitory Factor Positive Regulation Of Chromosome Organization Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Telomere Maintenance	Cytoplasm Aryl Hydrocarbon Receptor Binding Aryl Hydrocarbon Receptor Complex Microtubule-based Process Mitotic Centrosome Separation Centrosome Localization Axon Hillock Centrosome Separation
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