TTF2 and MYB

Number of citations of the paper that reports this interaction (PubMedID 12927788)
0

Data Source:
HPRD (two hybrid)

		TTF2	MYB
Description		transcription termination factor 2	MYB proto-oncogene, transcription factor
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Spliceosomal Complex Cytoplasm Cytosol Transcription Elongation Factor Complex	Nucleus Nucleoplasm Cytosol Nuclear Matrix RNA Polymerase II Transcription Regulator Complex
	Molecular Function	Nucleotide Binding DNA Binding Helicase Activity Protein Binding ATP Binding ATP-dependent Activity, Acting On DNA Zinc Ion Binding Hydrolase Activity Metal Ion Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding WD40-repeat Domain Binding
	Biological Process	DNA Repair DNA-templated Transcription Termination Termination Of RNA Polymerase II Transcription MRNA Processing RNA Splicing	G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Transcription By RNA Polymerase II Mitotic Cell Cycle Response To Hypoxia In Utero Embryonic Development Response To Ischemia Regulation Of DNA-templated Transcription Calcium Ion Transport Regulation Of Gene Expression Skeletal Muscle Cell Proliferation Stem Cell Division Myeloid Cell Differentiation B Cell Differentiation Erythrocyte Differentiation Positive Regulation Of Collagen Biosynthetic Process Positive Regulation Of Neuron Apoptotic Process T-helper 2 Cell Differentiation Negative Regulation Of Megakaryocyte Differentiation Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Spleen Development Thymus Development Embryonic Digestive Tract Development Positive Regulation Of Smooth Muscle Cell Proliferation Homeostasis Of Number Of Cells Positive Regulation Of Glial Cell Proliferation Myeloid Cell Development Cellular Response To Hydrogen Peroxide Cellular Response To Retinoic Acid Cellular Response To Interleukin-6 Positive Regulation Of Transforming Growth Factor Beta Production Negative Regulation Of Hematopoietic Progenitor Cell Differentiation Positive Regulation Of MiRNA Transcription Positive Regulation Of Hepatic Stellate Cell Proliferation Cellular Response To Leukemia Inhibitory Factor Positive Regulation Of Hepatic Stellate Cell Activation Positive Regulation Of Testosterone Secretion
Pathways			RUNX1 regulates transcription of genes involved in differentiation of HSCs Estrogen-dependent gene expression Transcriptional regulation of granulopoiesis Factors involved in megakaryocyte development and platelet production Specification of the neural plate border
Drugs
Diseases
GWAS			Aspartate aminotransferase levels ( 33547301 33339817 29403010) Basophil count ( 32888494) Basophil percentage of granulocytes ( 27863252) Basophil percentage of white cells ( 27863252 32888494) Beta thalassemia/hemoglobin E disease ( 20183929) Eosinophil count ( 29403010) Eosinophil percentage of white cells ( 32888494) Fetal hemoglobin levels in sickle cell anemia ( 25372704) Glycated hemoglobin levels ( 24647736 29483669 28898252) HbA2 levels ( 23043469) Hematocrit ( 19862010 29403010) Hematological and biochemical traits ( 20139978) Hematological parameters ( 19820697) Hematology traits ( 23263863) Hemoglobin ( 29403010) Hemoglobin A1c levels ( 29403010) Hemoglobin levels ( 26366553) Hodgkin's lymphoma ( 24149102) Lymphocyte percentage of white cells ( 32888494) Mean corpuscular hemoglobin ( 19862010 29403010 28548082 28453575 28031487 19853236 20139978 23263863) Mean corpuscular hemoglobin concentration ( 29403010 23263863 20139978) Mean corpuscular volume ( 19853236 29403010 19862010 23263863 20139978 28031487 28453575) Mean platelet volume ( 32888494) Monocyte count ( 32888494) Monocyte percentage of white cells ( 32888494) Multiple sclerosis ( 21833088) Myeloproliferative neoplasms ( 25849990) Neutrophil count ( 32888494) Neutrophil percentage of white cells ( 32888494) Obesity-related traits ( 23251661) Other erythrocyte phenotypes ( 19862010) Platelet count ( 29066854 24026423 33545615 26805783 28031487 22423221 19853236 22139419 20139978 29403010) Red blood cell count ( 29403010 28453575 28031487 20139978) Red blood cell traits ( 23935956 20927387) White blood cell count ( 29403010 20139978 32888494) White blood cell count (basophil) ( 27863252) White blood cell types ( 21738478)
Interacting Genes		27 interacting genes: CDC5L CDKL3 CEBPA CLPB DCP1A DRAP1 FZR1 GMEB2 HINFP HNRNPA1 HNRNPA2B1 KIF4A LINC01554 MATR3 MYB MYBL2 NVL PDCD6IP PRDX4 SKIL SMAD1 SMAD7 TACC3 TCF4 TNIP1 UBC ZSCAN1	49 interacting genes: BTRC CCND3 CEBPB CEBPE CHD3 CNOT9 CREBBP CSNK2A1 EP300 ERC2 FBXW2 FBXW5 FBXW7 H2AC4 H2BC3 H3-4 H3C1 H4C1 HIPK2 HLF KAT2A MAF MAPK1 MYBBP1A MYOZ2 NCL NCOR1 NLK PAIP1 PAX5 PIAS1 PML PPM1K RBX1 RPL4 SIN3A SKI SKP2 SMARCA2 SND1 SP100 SUMO1 SUMO2 TRIM28 TTF2 UBE2I UPF2 ZFHX3 ZMYND11
Entrez ID		8458	4602
HPRD ID		05280	01810
Ensembl ID		ENSG00000116830	ENSG00000118513
Uniprot IDs		Q9UNY4	P10242 Q708E9
PDB IDs
Enriched GO Terms of Interacting Partners?		Nucleus Identical Protein Binding Nuclear Matrix DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity, RNA Polymerase II-specific RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Regulation Of Nucleobase-containing Compound Metabolic Process RNA Metabolic Process WD40-repeat Domain Binding DNA Binding Regulation Of Transcription By RNA Polymerase II Transcription Regulator Complex MiRNA Binding Regulation Of Macromolecule Metabolic Process Heteromeric SMAD Protein Complex G-rich Strand Telomeric DNA Binding Positive Regulation Of Nucleobase-containing Compound Metabolic Process Nucleic Acid Metabolic Process Regulation Of Cell Cycle Regulation Of Metabolic Process Primary MiRNA Processing Regulation Of Primary Metabolic Process Positive Regulation Of Telomere Maintenance Regulation Of RNA Metabolic Process Nucleoplasm Lens Fiber Cell Differentiation Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process I-SMAD Binding Positive Regulation Of Cell Differentiation Catalytic Step 2 Spliceosome Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Response To Stress Regulation Of RNA Biosynthetic Process Protein Domain Specific Binding Mitotic Spindle Organization Regulation Of Gene Expression Positive Regulation Of Transcription By RNA Polymerase II DNA Damage Checkpoint Signaling DNA-templated Transcription Negative Regulation Of Cell Differentiation Regulation Of Chromosome Organization Transforming Growth Factor Beta Receptor Signaling Pathway Cellular Response To Leukemia Inhibitory Factor Blastocyst Formation Response To Leukemia Inhibitory Factor Positive Regulation Of Chromosome Organization Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Telomere Maintenance	Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Negative Regulation Of RNA Metabolic Process Regulation Of RNA Biosynthetic Process Negative Regulation Of DNA-templated Transcription Regulation Of RNA Metabolic Process Negative Regulation Of RNA Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Gene Expression Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Regulation Of Macromolecule Biosynthetic Process Nucleoplasm Nucleus PML Body Regulation Of Macromolecule Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Metabolic Process Regulation Of Metabolic Process DNA Binding Chromatin Organization Regulation Of Primary Metabolic Process Rhythmic Process Positive Regulation Of Macromolecule Metabolic Process Chromatin Remodeling Positive Regulation Of Biosynthetic Process Positive Regulation Of Metabolic Process SUMO Transferase Activity Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II Transcription Corepressor Activity Protein Sumoylation Histone H3K18 Acetyltransferase Activity Cellular Response To Stress Regulation Of Ubiquitin-dependent Protein Catabolic Process RNA Polymerase II-specific DNA-binding Transcription Factor Binding Regulation Of Protein Stability Chromatin Ubiquitin Protein Ligase Binding DNA Damage Response Protein Modification Process Macromolecule Metabolic Process Signal Transduction By P53 Class Mediator SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process
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