MAP1LC3A and ATG3

Number of citations of the paper that reports this interaction (PMID 19838173)
77

Data Source:
BioGRID (pull down, enzymatic study, pull down, affinity chromatography technology)

		MAP1LC3A	ATG3
Gene Name		microtubule-associated protein 1 light chain 3 alpha	autophagy related 3
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Pre-autophagosomal Structure Autophagic Vacuole Membrane Late Endosome Autophagic Vacuole Cytosol Microtubule Extrinsic Component Of Membrane Organelle Membrane Cytoplasmic Vesicle	Cytoplasmic Ubiquitin Ligase Complex Cytosol
	Molecular Function	Protein Binding Phospholipid Binding Microtubule Binding Phosphatidylethanolamine Binding GABA Receptor Binding	Protein Binding Atg8 Ligase Activity Atg12 Transferase Activity Ubiquitin-like Protein Transferase Activity Enzyme Binding
	Biological Process	Autophagic Vacuole Assembly Mitochondrion Degradation Cellular Response To Nitrogen Starvation Nucleophagy Membrane Fusion	Autophagic Vacuole Assembly Mitochondrion Degradation Cellular Protein Modification Process Protein Targeting To Membrane Protein Ubiquitination Mitochondrial Fragmentation Involved In Apoptotic Process Nucleophagy Regulation Of Cilium Assembly
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions		40 interactors: AKAP13 APP ATG101 ATG13 ATG3 ATG4B ATG7 BNIP3L DVL2 EPHA7 FAM134C FUNDC1 KIF15 KXD1 MAP1A MAP1S NBR1 OPTN PIAS4 PRPF40A RABGAP1 RABGAP1L RDH12 RTKN SQSTM1 SRPK1 TBC1D1 TBC1D10A TBC1D10B TBC1D16 TBC1D17 TBC1D2 TBC1D25 TBC1D2B TBC1D5 TBC1D7 TBC1D9 TBC1D9B TNIP1 TUBA4A	8 interactors: ATG12 ATG5 ATG7 BECN1 GABARAP GABARAPL2 MAP1LC3A MAP1LC3B
Entrez ID		84557	64422
HPRD ID		03144	10654
Ensembl ID		ENSG00000101460	ENSG00000144848
Uniprot IDs		Q9H492	Q9NT62
PDB IDs		3ECI
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Rab GTPase Activity Regulation Of Rab GTPase Activity Regulation Of Rab Protein Signal Transduction Autophagy Positive Regulation Of Ras GTPase Activity Regulation Of Ras Protein Signal Transduction Regulation Of Intracellular Signal Transduction Regulation Of Ras GTPase Activity Regulation Of Small GTPase Mediated Signal Transduction Positive Regulation Of GTPase Activity Regulation Of GTPase Activity Positive Regulation Of Hydrolase Activity Regulation Of Signal Transduction Macroautophagy Response To Starvation Regulation Of Signaling Positive Regulation Of Catalytic Activity Cellular Response To Starvation Cellular Response To Nutrient Levels Regulation Of Catalytic Activity Positive Regulation Of Metabolic Process Cellular Response To Extracellular Stimulus Response To Nutrient Levels Response To Extracellular Stimulus Mitochondrion Degradation Catabolic Process Positive Regulation Of Autophagy Organelle Disassembly Autophagic Vacuole Assembly Regulation Of Metabolic Process Response To External Stimulus Intracellular Transport Retrograde Transport, Endosome To Golgi Nucleophagy Establishment Of Localization In Cell Cellular Localization Endosomal Transport Vacuole Organization Regulation Of Autophagy Cell Death Death Response To Stress Regulation Of Cellular Process Apoptotic Process Programmed Cell Death Organelle Organization Positive Regulation Of Macroautophagy Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Cellular Response To Nitrogen Starvation	Nucleophagy Cellular Response To Nitrogen Starvation Mitochondrion Degradation Organelle Disassembly Autophagic Vacuole Assembly Cellular Response To Starvation Autophagy Macroautophagy Response To Starvation Cellular Response To Nutrient Levels Cellular Response To Extracellular Stimulus Vacuole Organization Response To Nutrient Levels Response To Extracellular Stimulus Mitochondrion Organization Organelle Assembly Membrane Fusion Cellular Response To Stress Catabolic Process Response To External Stimulus C-terminal Protein Lipidation Negative Regulation Of Histone H4-K16 Acetylation Organelle Organization Cellular Component Assembly Response To Stress Negative Regulation Of Histone H4 Acetylation Negative Stranded Viral RNA Replication Membrane Organization Protein Lipidation Regulation Of Histone H4 Acetylation Positive Regulation Of Mucus Secretion Lipoprotein Biosynthetic Process Positive Regulation Of Macroautophagy Regulation Of Mucus Secretion Negative Regulation Of Histone Acetylation Cell Communication Negative Regulation Of Peptidyl-lysine Acetylation Negative Regulation Of Protein Acetylation Viral Genome Replication Lipoprotein Metabolic Process Post-translational Protein Modification Cellular Response To Stimulus Positive Regulation Of Autophagy Regulation Of Histone Acetylation Negative Regulation Of Type I Interferon Production Cardiac Muscle Cell Development Response To Stimulus Cellular Response To Aluminum Ion Negative Regulation Of Chromosome Organization Regulation Of Type I Interferon Production
Tagcloud ?		acquiring adenocarcinoma autophagy became came constitutive date demethylation egfr erlotinib escaping exposing gefitinib ie immunoreactivity necessarily neoplastic novo overcoming parental pc9 pivotal predictor pronounced restores tkis treating tumoural	alkaloids anticancer araguspongine araguspongines atg16l atg7 autophagic autophagy bt cascade docking dysregulations inositol kinases lc3a lyte macrocyclic marine met overexpressing oxaquinolizidine remarkably silico sponge trisphosphate tyrosine vacuole xestospongia xestospongin
Tagcloud (Difference) ?		acquiring adenocarcinoma became came constitutive date demethylation egfr erlotinib escaping exposing gefitinib ie immunoreactivity necessarily neoplastic novo overcoming parental pc9 pivotal predictor pronounced restores tkis treating tumoural	alkaloids anticancer araguspongine araguspongines atg16l atg7 autophagic bt cascade docking dysregulations inositol kinases lyte macrocyclic marine met overexpressing oxaquinolizidine remarkably silico sponge trisphosphate tyrosine vacuole xestospongia xestospongin
Tagcloud (Intersection) ?		autophagy lc3a