SKP2 and WEE1

Number of citations of the paper that reports this interaction (PMID 15070733)
128

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo)

		SKP2	WEE1
Gene Name		S-phase kinase-associated protein 2, E3 ubiquitin protein ligase	WEE1 G2 checkpoint kinase
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Aggresome SCF Ubiquitin Ligase Complex	Nucleus Nucleoplasm Cytoplasm
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Identical Protein Binding	Magnesium Ion Binding Protein Serine/threonine Kinase Activity Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Protein Binding ATP Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle G2/M Transition Of Mitotic Cell Cycle Protein Polyubiquitination Mitotic Cell Cycle Cell Proliferation Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Intracellular Estrogen Receptor Signaling Pathway Positive Regulation Of Smooth Muscle Cell Proliferation Regulation Of Cell Cycle Cellular Response To Cell-matrix Adhesion	G1/S Transition Of Mitotic Cell Cycle G2/M Transition Of Mitotic Cell Cycle Microtubule Cytoskeleton Organization Mitotic Cell Cycle Mitotic Nuclear Division Blood Coagulation Peptidyl-tyrosine Phosphorylation Establishment Of Cell Polarity Neuron Projection Morphogenesis Cell Division Regulation Of Cell Cycle
Pathways		APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Antigen processing: Ubiquitination & Proteasome degradation G1 Phase S Phase Cyclin E associated events during G1/S transition APC/C-mediated degradation of cell cycle proteins Cell Cycle, Mitotic SCF(Skp2)-mediated degradation of p27/p21 Cyclin D associated events in G1 G1/S Transition Regulation of mitotic cell cycle Class I MHC mediated antigen processing & presentation Cyclin A:Cdk2-associated events at S phase entry SCF(Skp2)-mediated degradation of p27/p21 Mitotic G1-G1/S phases Adaptive Immune System	G2/M DNA damage checkpoint G2/M Checkpoints G2/M Transition S Phase Cyclin E associated events during G1/S transition Factors involved in megakaryocyte development and platelet production Cell Cycle, Mitotic Cyclin A/B1 associated events during G2/M transition G1/S Transition Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex Cell Cycle Checkpoints Cyclin A:Cdk2-associated events at S phase entry Mitotic G1-G1/S phases Mitotic G2-G2/M phases Polo-like kinase mediated events G2/M DNA replication checkpoint
Drugs
Diseases
GWAS
Protein-Protein Interactions		54 interactors: AKT1 BTG1 BTG2 CCNA2 CCNE1 CCNT1 CDC14B CDC34 CDH1 CDK2 CDK9 CDKN1A CDKN1B CDKN1C CDT1 CEBPA CHKA CKS1B CKS1BP7 CUL1 CUL4A DDB1 DUSP1 E2F1 ELF4 ESR1 FZR1 GPS1 KPNA1 KPNA6 MYB MYBL2 MYC NLK ORC1 PFDN1 PIM1 PSMD9 RAG2 RB1 RBL2 RND3 SIRT4 SIRT6 SKP1 SMAD4 TAL1 TCF3 TRIM21 UBB VHL WEE1 YWHAB YY1	21 interactors: BRD8 BRSK1 BRSK2 BTRC CASP3 CDCA3 CDK1 CDK2 CRK CSNK2A1 FBXW11 NEDD4 PIN1 PLK1 SKP2 SMAD3 SMURF1 YWHAB YWHAG YWHAQ YWHAZ
Entrez ID		6502	7465
HPRD ID		03256	01907
Ensembl ID		ENSG00000145604	ENSG00000166483
Uniprot IDs		Q13309	P30291 Q86V29
PDB IDs		1FQV 1FS1 1FS2 1LDK 2ASS 2AST	1X8B 2IN6 2IO6 2Z2W 3BI6 3BIZ 3CQE 3CR0
Enriched GO Terms of Interacting Partners?		G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Regulation Of Cell Cycle Cell Cycle Cell Cycle Process Mitotic Cell Cycle Mitotic Cell Cycle Process Regulation Of Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Metabolic Process Positive Regulation Of Gene Expression Regulation Of Cell Cycle Process Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process Regulation Of Gene Expression Regulation Of Transcription, DNA-templated Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Regulation Of Cellular Process Regulation Of Mitotic Cell Cycle Cell Cycle Checkpoint Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Cellular Metabolic Process Cellular Metabolic Process Positive Regulation Of Cell Cycle Regulation Of Cell Proliferation DNA Damage Checkpoint Cellular Response To DNA Damage Stimulus Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Cell Cycle Phase Transition Nitrogen Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Cell Cycle Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle G1/S Phase Transition Negative Regulation Of Gene Expression Regulation Of Ubiquitin-protein Transferase Activity Cellular Response To Stress Negative Regulation Of Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Catalytic Activity Negative Regulation Of Transferase Activity DNA Metabolic Process Cellular Protein Modification Process	G2/M Transition Of Mitotic Cell Cycle Cell Cycle Cell Cycle Process Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Mitotic Cell Cycle Process Cellular Response To Stimulus Mitotic Cell Cycle Cell Communication Positive Regulation Of Intracellular Transport Regulation Of Signaling Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Metabolic Process Proteasomal Protein Catabolic Process Regulation Of Intracellular Transport Regulation Of Protein Metabolic Process Signaling Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Signal Transduction Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Response To Stimulus Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Intrinsic Apoptotic Signaling Pathway Proteolysis Involved In Cellular Protein Catabolic Process Apoptotic Signaling Pathway Regulation Of Ubiquitin-protein Transferase Activity Regulation Of Cellular Protein Metabolic Process Cellular Protein Catabolic Process Signal Transduction Cellular Macromolecule Catabolic Process Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Protein Catabolic Process Cellular Protein Modification Process Regulation Of Organelle Organization Positive Regulation Of Signal Transduction Regulation Of Cell Cycle Apoptotic Process Regulation Of Establishment Of Protein Localization Programmed Cell Death Regulation Of Cellular Localization Cell Death Death Positive Regulation Of Proteolysis Regulation Of Cellular Component Organization Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Localization Positive Regulation Of Mitochondrion Organization Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle
Tagcloud ?		antisense box cdc53 cdk2 cip1 complex cul cullin deregulation e3 g1 hallmark kip1 ligase lived member oligodeoxynucleotides oligonucleotides p19 p21 p27 p45 proteolysis raises scf skp1 transformed ubiquitin waf1	arrested associates becomes cascade cdc2 entry g2 hyperphosphorylated immunoprecipitates inactive maintained mapk maturation mpf myt1 oocyte oocytes p34 p90 phosphorylates precise preferentially rsk stock thr14 trigger turn tyr15 xenopus
Tagcloud (Difference) ?		antisense box cdc53 cdk2 cip1 complex cul cullin deregulation e3 g1 hallmark kip1 ligase lived member oligodeoxynucleotides oligonucleotides p19 p21 p27 p45 proteolysis raises scf skp1 transformed ubiquitin waf1	arrested associates becomes cascade cdc2 entry g2 hyperphosphorylated immunoprecipitates inactive maintained mapk maturation mpf myt1 oocyte oocytes p34 p90 phosphorylates precise preferentially rsk stock thr14 trigger turn tyr15 xenopus
Tagcloud (Intersection) ?