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SKP2 and CFLAR
Number of citations of the paper that reports this interaction (PubMedID
32313199
)
41
Data Source:
BioGRID
(unspecified method)
SKP2
CFLAR
Description
S-phase kinase associated protein 2
CASP8 and FADD like apoptosis regulator
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Nucleolus
Cytoplasm
Cytosol
SCF Ubiquitin Ligase Complex
Cytoplasm
Cytosol
Death-inducing Signaling Complex
CD95 Death-inducing Signaling Complex
Ripoptosome
Molecular Function
Protein Binding
Identical Protein Binding
Ubiquitin-like Ligase-substrate Adaptor Activity
Protease Binding
Cysteine-type Endopeptidase Activity
Death Receptor Binding
Protein Binding
Enzyme Activator Activity
Cysteine-type Peptidase Activity
Protein-containing Complex Binding
Biological Process
G1/S Transition Of Mitotic Cell Cycle
G2/M Transition Of Mitotic Cell Cycle
Protein Polyubiquitination
DNA Double-strand Break Processing
Immune System Process
Ubiquitin-dependent Protein Catabolic Process
Protein Ubiquitination
SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Intracellular Estrogen Receptor Signaling Pathway
Regulation Of Apoptotic Process
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Innate Immune Response
Positive Regulation Of Smooth Muscle Cell Proliferation
Defense Response To Virus
Regulation Of Cell Cycle
Protein K63-linked Ubiquitination
Protein K48-linked Ubiquitination
Cellular Response To Cell-matrix Adhesion
Positive Regulation Of Protein Polyubiquitination
Positive Regulation Of Double-strand Break Repair Via Homologous Recombination
Protein Localization To Site Of Double-strand Break
Response To Hypoxia
Proteolysis
Apoptotic Process
Skeletal Muscle Tissue Development
Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Negative Regulation Of Cardiac Muscle Cell Apoptotic Process
Positive Regulation Of Neuron Projection Development
Skeletal Muscle Atrophy
Regulation Of Skeletal Muscle Satellite Cell Proliferation
Skeletal Myofibril Assembly
Macrophage Differentiation
Cellular Response To Insulin Stimulus
Response To Testosterone
Regulation Of Apoptotic Process
Negative Regulation Of Apoptotic Process
Positive Regulation Of Canonical NF-kappaB Signal Transduction
Skeletal Muscle Tissue Regeneration
Positive Regulation Of Neuron Apoptotic Process
Regulation Of Necroptotic Process
Positive Regulation Of ERK1 And ERK2 Cascade
Cellular Response To Epidermal Growth Factor Stimulus
Cellular Response To Estradiol Stimulus
Cellular Response To Hypoxia
Cellular Response To Dexamethasone Stimulus
Cellular Response To Nitric Oxide
Positive Regulation Of Glomerular Mesangial Cell Proliferation
Negative Regulation Of Myoblast Fusion
Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Positive Regulation Of Extracellular Matrix Organization
Negative Regulation Of Reactive Oxygen Species Biosynthetic Process
Negative Regulation Of Cellular Response To Transforming Growth Factor Beta Stimulus
Negative Regulation Of Hepatocyte Apoptotic Process
Negative Regulation Of Epithelial Cell Apoptotic Process
Positive Regulation Of Hepatocyte Proliferation
Negative Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
SCF(Skp2)-mediated degradation of p27/p21
Ub-specific processing proteases
Orc1 removal from chromatin
Cyclin D associated events in G1
Regulation of RUNX2 expression and activity
Neddylation
Aberrant regulation of mitotic exit in cancer due to RB1 defects
Regulation of BACH1 activity
Antigen processing: Ubiquitination & Proteasome degradation
TRAIL signaling
Drugs
Diseases
GWAS
Appendicular lean mass (
33097823
)
Birth weight (
31043758
)
Mean corpuscular hemoglobin (
32888494
)
Mean corpuscular volume (
32888494
)
Mean reticulocyte volume (
32888494
)
Mean spheric corpuscular volume (
32888494
)
Metabolite levels (
23823483
)
Red cell distribution width (
27863252
32888494
)
Appendicular lean mass (
33097823
)
Rheumatoid arthritis (
24390342
30423114
)
Triptolide cytotoxicity (
26121980
)
Interacting Genes
68 interacting genes:
ACE2
AKT1
BRAP
BRCA1
BTG1
BTG2
CCNA2
CCNE1
CCNT1
CDC14B
CDC34
CDK2
CDK9
CDKN1B
CDKN1C
CDT1
CEBPA
CFLAR
CHKA
CKS1B
CKS1BP7
CUL1
CUL4A
DDB1
DUSP1
E2F1
ELF4
ESR1
FZR1
GPS1
KPNA1
KPNA6
MEF2D
MTOR
MYB
MYBL2
MYC
NHERF1
NLK
NUDT1
ORC1
PAX8
PDCD4
PFDN1
PIM1
POLR1A
POLR2A
PSMD9
PTK2
RAG2
RB1
RBL2
RND3
SIRT4
SIRT6
SKP1
SMAD4
SQSTM1
STK11
TAL1
TCF3
TLE5
TRIM21
UBB
VHL
WEE1
YWHAB
YY1
34 interacting genes:
BCL2L1
CASP10
CASP2
CASP3
CASP6
CASP7
CASP8
CUL1
DAXX
DEDD
DEDD2
FADD
IKBKB
MAP2K4
MAP2K7
MEX3B
NEURL3
NFKB1
PSEN2
RAF1
RBX1
RIPK1
RIPK2
RLIM
RNF8
SKP1
SKP2
SMAD3
SPATS1
TNFRSF10B
TRAF1
TRAF2
TRIM31
USP8
Entrez ID
6502
8837
HPRD ID
03256
04671
Ensembl ID
ENSG00000145604
ENSG00000003402
Uniprot IDs
Q13309
A0A024R3Y4
A0A336TY74
B4E361
E9PAP3
O15519
Q59F61
PDB IDs
1FQV
1FS1
1FS2
1LDK
2ASS
2AST
7B5L
7B5M
7B5R
7LUO
7Z8T
7Z8V
7ZBW
7ZBZ
8BYA
8BYL
8CDJ
8CDK
8OR0
8OR3
8OR4
2N5R
3H11
3H13
6M6O
7DEE
7LXC
8YBX
8YD7
8YD8
8YM4
8YM5
8YM6
8YNI
8YNK
8YNL
8YNM
8YNN
Enriched GO Terms of Interacting Partners
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Nucleoplasm
Regulation Of Primary Metabolic Process
Regulation Of Metabolic Process
Regulation Of Macromolecule Metabolic Process
Regulation Of Mitotic Cell Cycle
Nucleus
Regulation Of Cell Cycle
Positive Regulation Of Metabolic Process
Regulation Of Nucleobase-containing Compound Metabolic Process
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Positive Regulation Of Macromolecule Metabolic Process
Regulation Of Mitotic Cell Cycle Phase Transition
Regulation Of Cell Population Proliferation
Positive Regulation Of RNA Metabolic Process
Cellular Response To Stress
Regulation Of Cell Cycle Phase Transition
Macromolecule Metabolic Process
Regulation Of DNA-templated Transcription
Regulation Of RNA Biosynthetic Process
Regulation Of Apoptotic Process
Positive Regulation Of RNA Biosynthetic Process
Positive Regulation Of DNA-templated Transcription
Regulation Of Programmed Cell Death
Regulation Of RNA Metabolic Process
Negative Regulation Of Metabolic Process
Nucleic Acid Metabolic Process
G1/S Transition Of Mitotic Cell Cycle
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Cell Cycle G1/S Phase Transition
Regulation Of Protein Metabolic Process
Negative Regulation Of Cell Cycle
DNA-templated Transcription
Negative Regulation Of Macromolecule Metabolic Process
Negative Regulation Of Biosynthetic Process
Mitotic Cell Cycle Phase Transition
Negative Regulation Of Macromolecule Biosynthetic Process
Regulation Of Cell Cycle Process
Cell Cycle Phase Transition
Intracellular Signal Transduction
Negative Regulation Of RNA Metabolic Process
Negative Regulation Of DNA-templated Transcription
Nucleobase-containing Compound Metabolic Process
Negative Regulation Of RNA Biosynthetic Process
Regulation Of Macromolecule Biosynthetic Process
Regulation Of Gene Expression
Protein Modification Process
Positive Regulation Of Biosynthetic Process
Cell Population Proliferation
Regulation Of Protein Modification Process
Regulation Of Cell Differentiation
Apoptotic Process
Cell Death
Programmed Cell Death
Apoptotic Signaling Pathway
Regulation Of Apoptotic Process
Regulation Of Programmed Cell Death
Extrinsic Apoptotic Signaling Pathway
MAPK Cascade
Intracellular Signal Transduction
Positive Regulation Of Apoptotic Process
Positive Regulation Of Programmed Cell Death
Positive Regulation Of Canonical NF-kappaB Signal Transduction
Regulation Of Canonical NF-kappaB Signal Transduction
Cell Surface Receptor Signaling Pathway
Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Intrinsic Apoptotic Signaling Pathway
Signal Transduction
Protein Metabolic Process
JNK Cascade
Cysteine-type Endopeptidase Activity
Positive Regulation Of Signal Transduction
Positive Regulation Of Signaling
Ubiquitin Protein Ligase Binding
Ripoptosome
Intracellular Signaling Cassette
Positive Regulation Of Neuron Apoptotic Process
Proteolysis
Death-inducing Signaling Complex
Regulation Of Neuron Apoptotic Process
Positive Regulation Of Cell Communication
Positive Regulation Of Intracellular Signal Transduction
Execution Phase Of Apoptosis
Response To Stress
Cytosol
Protein Modification Process
Post-translational Protein Modification
Response To External Biotic Stimulus
Cellular Response To Mechanical Stimulus
Cellular Response To Staurosporine
Death Effector Domain Binding
Protein Polyubiquitination
Cysteine-type Peptidase Activity
Regulation Of Signal Transduction
Death Receptor Binding
T Cell Activation
Regulation Of Intracellular Signal Transduction
Protein Maturation
Positive Regulation Of Protein Metabolic Process
Regulation Of Signaling
Regulation Of Cytokine Production
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Tagcloud (Intersection)
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