CAND1 and CA9

Number of citations: 0 (PubMedID 28388044)
Data Source: BioGRID (unspecified method, affinity chromatography technology)

		CAND1	CA9
Name		cullin associated and neddylation dissociated 1	carbonic anhydrase 9
Structure
GO Annotations	Cellular Component	Ubiquitin Ligase Complex Extracellular Region Nucleus Nucleoplasm Cytoplasm Golgi Apparatus Cytosol Membrane Cullin-RING Ubiquitin Ligase Complex Secretory Granule Lumen Extracellular Exosome Ficolin-1-rich Granule Lumen	Nucleus Nucleolus Plasma Membrane Membrane Basolateral Plasma Membrane Microvillus Membrane Cell Projection
	Molecular Function	Protein Binding TBP-class Protein Binding	Carbonate Dehydratase Activity Protein Binding Zinc Ion Binding Lyase Activity Metal Ion Binding Molecular Function Activator Activity
	Biological Process	SCF Complex Assembly Protein Ubiquitination Cell Differentiation Negative Regulation Of Catalytic Activity Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Polymerase II Transcription Preinitiation Complex Assembly	Response To Hypoxia Morphogenesis Of An Epithelium Response To Xenobiotic Stimulus Response To Testosterone Secretion
Pathways		Neutrophil degranulation Neddylation Iron uptake and transport	Regulation of gene expression by Hypoxia-inducible Factor Reversible hydration of carbon dioxide
Drugs		None	Benzthiazide Benzthiazide Cyclothiazide Hydroflumethiazide Zonisamide Girentuximab Ellagic acid Sodium carbonate DTP-348
GWAS		Amyotrophic lateral sclerosis (C9orf72 mutation interaction) ( 22959728 ) Epstein-Barr virus copy number in lymphoblastoid cell lines ( 28654678 ) Expressive vocabulary in infants ( 25226531 ) HDL cholesterol levels ( 32203549 ) Hippocampal atrophy ( 19668339 ) Metabolite levels ( 23823483 ) Systolic blood pressure ( 30224653 ) Triglyceride levels ( 32203549 )	No GWAS studies recorded
Interacting Genes		20 interacting genes: CA9 CEBPA CNOT3 CUL1 CUL2 CUL3 CUL4A CUL4B DCUN1D2 DCUN1D4 DCUN1D5 DUX4 FILNC1 HSPA13 MTNR1A RBX1 RNF10 SKP1 SRPK2 UBE2M	6 interacting genes: CAND1 CDH1 CSRP1 CTNNA1 CTNNB1 GLRX3
Entrez ID		55832	768
HPRD ID		06983	04417
Ensembl ID		ENSG00000111530	ENSG00000107159
Uniprot IDs		Q86VP6	A0A0S2Z341 A0A0S2Z3D0 Q16790
PDB IDs		1U6G 4A0C 7Z8R 7Z8T 7Z8V 7ZBW 7ZBZ 8CDJ 8CDK 8H3Q 8OR0 8OR2 8OR3 8OR4	2HKF 3IAI 5DVX 5FL4 5FL5 5FL6 6FE0 6FE1 6FE2 6G98 6G9U 6QN2 6QN5 6QN6 6QUT 6RQN 6RQQ 6RQU 6RQW 6TL5 6TL6 6Y74 7POM 8CO0 8Q18 8Q19 8Q1A
GO Terms Enriched among Interactors		Cullin-RING Ubiquitin Ligase Complex Ubiquitin Ligase Complex Scaffold Activity Protein Modification By Small Protein Conjugation Post-translational Protein Modification Protein Neddylation Cullin Family Protein Binding G1/S Transition Of Mitotic Cell Cycle Cell Cycle G1/S Phase Transition Protein Modification Process Protein Monoubiquitination Ubiquitin-like Protein Binding Positive Regulation Of Protein Neddylation Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Proteasomal Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Metabolic Process Modification-dependent Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Via The C-end Degron Rule Pathway Protein Ubiquitination Protein Catabolic Process Positive Regulation Of Post-translational Protein Modification Cul4A-RING E3 Ubiquitin Ligase Complex Proteolysis Involved In Protein Catabolic Process SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process SCF Ubiquitin Ligase Complex Ubiquitin Protein Ligase Binding Macromolecule Catabolic Process Regulation Of Protein Neddylation Positive Regulation Of Epithelial Cell Apoptotic Process Regulation Of Protein Metabolic Process Positive Regulation Of Metabolic Process Protein Metabolic Process Cul4-RING E3 Ubiquitin Ligase Complex Nucleus Macromolecule Metabolic Process Protein K48-linked Ubiquitination Ubiquitin Conjugating Enzyme Binding Cul7-RING Ubiquitin Ligase Complex Regulation Of Post-translational Protein Modification Base-excision Repair, AP Site Formation Via Deaminated Base Removal NEDD8 Transferase Activity Protein Polyubiquitination Regulation Of Cell Cycle Cul4B-RING E3 Ubiquitin Ligase Complex Regulation Of Epithelial Cell Apoptotic Process Type I Interferon-mediated Signaling Pathway Apoptotic Signaling Pathway Positive Regulation Of Cell Cycle	Cellular Response To Indole-3-methanol Response To Indole-3-methanol Flotillin Complex Catenin Complex Negative Regulation Of Cell Development Gamma-catenin Binding Cell-cell Junction Assembly Negative Regulation Of Neurogenesis Z Disc Negative Regulation Of Nervous System Development Cell-cell Adhesion Regulation Of Protein Localization To Nucleus Negative Regulation Of Multicellular Organismal Process Cell-cell Junction Organization Regulation Of Protein Sumoylation Adherens Junction Lamellipodium Disordered Domain Specific Binding Cell Junction Apical Junction Complex Negative Regulation Of Cell Differentiation Cell-cell Adhesion Mediated By Cadherin Response To Alcohol Cell Junction Assembly Regulation Of Neuroblast Proliferation Neuroblast Proliferation Intercalated Disc Regulation Of Cell Development Cadherin Binding Cell Adhesion Adherens Junction Organization Cellular Response To Oxygen-containing Compound Apoptotic Signaling Pathway Regulation Of Protein Localization Negative Regulation Of Developmental Process Lateral Plasma Membrane Regulation Of Neurogenesis Odontogenesis Of Dentin-containing Tooth Ligase Inhibitor Activity Glial Cell Fate Determination Canonical Wnt Signaling Pathway Involved In Mesenchymal Stem Cell Differentiation Anchoring Junction Focal Adhesion Regulation Of Nervous System Development Negative Regulation Of Post-translational Protein Modification Beta-catenin Binding Regulation Of Cell-cell Adhesion Positive Regulation Of Protein Localization To Nucleus Cell Junction Organization Epidermal Cell Differentiation