CAND1 and CUL4A

Number of citations: 73 (PubMedID 35831314)
Data Source: BioGRID (affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology), HPRD (in vivo)

		CAND1	CUL4A
Name		cullin associated and neddylation dissociated 1	cullin 4A
Structure
GO Annotations	Cellular Component	Ubiquitin Ligase Complex Extracellular Region Nucleus Nucleoplasm Cytoplasm Golgi Apparatus Cytosol Membrane Cullin-RING Ubiquitin Ligase Complex Secretory Granule Lumen Extracellular Exosome Ficolin-1-rich Granule Lumen	Nucleus Nucleoplasm Cytoplasm Cullin-RING Ubiquitin Ligase Complex Cul4A-RING E3 Ubiquitin Ligase Complex Cul4-RING E3 Ubiquitin Ligase Complex
	Molecular Function	Protein Binding TBP-class Protein Binding	Protein Binding Ubiquitin Protein Ligase Binding Ubiquitin Protein Ligase Activity Ubiquitin Ligase Complex Scaffold Activity
	Biological Process	SCF Complex Assembly Protein Ubiquitination Cell Differentiation Negative Regulation Of Catalytic Activity Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Polymerase II Transcription Preinitiation Complex Assembly	G1/S Transition Of Mitotic Cell Cycle In Utero Embryonic Development DNA Repair Ubiquitin-dependent Protein Catabolic Process DNA Damage Response Spermatogenesis Cell Population Proliferation Positive Regulation Of Cell Population Proliferation Protein Ubiquitination Hemopoiesis Negative Regulation Of Granulocyte Differentiation Developmental Process Cellular Response To UV Somatic Stem Cell Population Maintenance MiRNA-mediated Gene Silencing By MRNA Destabilization T Cell Activation Ribosome Biogenesis Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Catabolic Process Rhythmic Process Regulation Of Protein Metabolic Process Type I Interferon-mediated Signaling Pathway Intrinsic Apoptotic Signaling Pathway Base-excision Repair, AP Site Formation Via Deaminated Base Removal Ubiquitin-dependent Protein Catabolic Process Via The C-end Degron Rule Pathway Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of DNA Damage Checkpoint Regulation Of Nucleotide-excision Repair
Pathways		Neutrophil degranulation Neddylation Iron uptake and transport	Recognition of DNA damage by PCNA-containing replication complex DNA Damage Recognition in GG-NER Formation of Incision Complex in GG-NER Dual Incision in GG-NER Formation of TC-NER Pre-Incision Complex Transcription-Coupled Nucleotide Excision Repair (TC-NER) Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER Neddylation
GWAS		Amyotrophic lateral sclerosis (C9orf72 mutation interaction) ( 22959728 ) Epstein-Barr virus copy number in lymphoblastoid cell lines ( 28654678 ) Expressive vocabulary in infants ( 25226531 ) HDL cholesterol levels ( 32203549 ) Hippocampal atrophy ( 19668339 ) Metabolite levels ( 23823483 ) Systolic blood pressure ( 30224653 ) Triglyceride levels ( 32203549 )	Apolipoprotein A1 levels ( 32203549 ) Atrial fibrillation ( 30061737 ) Bipolar disorder ( 31043756 34002096 ) HDL cholesterol levels ( 32203549 ) Immature fraction of reticulocytes ( 32888494 ) Intracranial aneurysm ( 30823506 ) Mean corpuscular hemoglobin ( 32888494 ) Mean corpuscular volume ( 32888494 ) Mean platelet volume ( 32888494 ) Mean reticulocyte volume ( 32888494 ) Mean spheric corpuscular volume ( 32888494 ) Platelet distribution width ( 27863252 32888494 ) Red cell distribution width ( 32888494 )
Interacting Genes		20 interacting genes: CA9 CEBPA CNOT3 CUL1 CUL2 CUL3 CUL4A CUL4B DCUN1D2 DCUN1D4 DCUN1D5 DUX4 FILNC1 HSPA13 MTNR1A RBX1 RNF10 SKP1 SRPK2 UBE2M	25 interacting genes: CAND1 CDKN1B CENPA CHEK1 COMMD1 COPS2 DCUN1D4 DDB1 DDB2 H1-2 H3C1 HOXA9 LNCAROD PAFAH1B1 RBX1 SALL2 SENP8 SKP2 ST7 TP53 TUBG1 UBC UBE2D1 UBE2E3 UBE2M
Entrez ID		55832	8451
HPRD ID		06983	07218
Ensembl ID		ENSG00000111530	ENSG00000139842
Uniprot IDs		Q86VP6	A0A087WWN2 A0A0A0MR50 Q13619
PDB IDs		1U6G 4A0C 7Z8R 7Z8T 7Z8V 7ZBW 7ZBZ 8CDJ 8CDK 8H3Q 8OR0 8OR2 8OR3 8OR4	2HYE 4A0K 7OKQ 7OPC 7OPD 8B3G 8B3I
GO Terms Enriched among Interactors		Cullin-RING Ubiquitin Ligase Complex Ubiquitin Ligase Complex Scaffold Activity Protein Modification By Small Protein Conjugation Post-translational Protein Modification Protein Neddylation Cullin Family Protein Binding G1/S Transition Of Mitotic Cell Cycle Cell Cycle G1/S Phase Transition Protein Modification Process Protein Monoubiquitination Ubiquitin-like Protein Binding Positive Regulation Of Protein Neddylation Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Proteasomal Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Metabolic Process Modification-dependent Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Via The C-end Degron Rule Pathway Protein Ubiquitination Protein Catabolic Process Positive Regulation Of Post-translational Protein Modification Cul4A-RING E3 Ubiquitin Ligase Complex Proteolysis Involved In Protein Catabolic Process SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process SCF Ubiquitin Ligase Complex Ubiquitin Protein Ligase Binding Macromolecule Catabolic Process Regulation Of Protein Neddylation Positive Regulation Of Epithelial Cell Apoptotic Process Regulation Of Protein Metabolic Process Positive Regulation Of Metabolic Process Protein Metabolic Process Cul4-RING E3 Ubiquitin Ligase Complex Nucleus Macromolecule Metabolic Process Protein K48-linked Ubiquitination Ubiquitin Conjugating Enzyme Binding Cul7-RING Ubiquitin Ligase Complex Regulation Of Post-translational Protein Modification Base-excision Repair, AP Site Formation Via Deaminated Base Removal NEDD8 Transferase Activity Protein Polyubiquitination Regulation Of Cell Cycle Cul4B-RING E3 Ubiquitin Ligase Complex Regulation Of Epithelial Cell Apoptotic Process Type I Interferon-mediated Signaling Pathway Apoptotic Signaling Pathway Positive Regulation Of Cell Cycle	Post-translational Protein Modification Protein Modification By Small Protein Conjugation Cul4A-RING E3 Ubiquitin Ligase Complex Nucleotide-excision Repair Protein Neddylation Cul4B-RING E3 Ubiquitin Ligase Complex Protein Modification Process Nucleus Positive Regulation Of Post-translational Protein Modification Regulation Of Post-translational Protein Modification Protein Ubiquitination Nucleoplasm Cullin Family Protein Binding Cellular Response To UV Cul4-RING E3 Ubiquitin Ligase Complex Base-excision Repair, AP Site Formation Via Deaminated Base Removal Cellular Response To Light Stimulus Protein K48-linked Ubiquitination Positive Regulation Of Protein Ubiquitination Positive Regulation Of RNA Polymerase II Transcription Preinitiation Complex Assembly NEDD8 Transferase Activity Regulation Of Protein Modification Process Ubiquitin-protein Transferase Activity DNA Damage Response, Signal Transduction By P53 Class Mediator Epigenetic Regulation Of Gene Expression Protein Polyubiquitination Mitotic Cell Cycle Phase Transition Signal Transduction In Response To DNA Damage Regulation Of Mitotic Cell Cycle DNA Metabolic Process Macromolecule Metabolic Process Response To UV Cellular Response To Antibiotic Cell Cycle Phase Transition DNA Repair Protein-containing Complex Protein Metabolic Process UV-damage Excision Repair Cellular Response To Radiation Protein Deneddylation DNA Damage Response Negative Regulation Of Mitophagy Chromosome Organization Positive Regulation Of Protein Metabolic Process Interferon-mediated Signaling Pathway Protein-containing Complex Binding Regulation Of Protein Ubiquitination Nuclear Membrane Disassembly Inner Cell Mass Cell Proliferation Replicative Senescence