CAND1 and CUL4B

Number of citations: 0 (PubMedID 12609982)
Data Source: HPRD (in vitro)

		CAND1	CUL4B
Name		cullin associated and neddylation dissociated 1	cullin 4B
Structure
GO Annotations	Cellular Component	Ubiquitin Ligase Complex Extracellular Region Nucleus Nucleoplasm Cytoplasm Golgi Apparatus Cytosol Membrane Cullin-RING Ubiquitin Ligase Complex Secretory Granule Lumen Extracellular Exosome Ficolin-1-rich Granule Lumen	Nucleus Nucleoplasm Cytoplasm Cytosol Cullin-RING Ubiquitin Ligase Complex Cul4A-RING E3 Ubiquitin Ligase Complex Cul4B-RING E3 Ubiquitin Ligase Complex Extracellular Exosome Cul4-RING E3 Ubiquitin Ligase Complex
	Molecular Function	Protein Binding TBP-class Protein Binding	Damaged DNA Binding Protein Binding Ubiquitin Protein Ligase Binding
	Biological Process	SCF Complex Assembly Protein Ubiquitination Cell Differentiation Negative Regulation Of Catalytic Activity Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Polymerase II Transcription Preinitiation Complex Assembly	G1/S Transition Of Mitotic Cell Cycle Protein Polyubiquitination DNA Repair Ubiquitin-dependent Protein Catabolic Process DNA Damage Response Gene Expression Proteasomal Protein Catabolic Process Protein Ubiquitination Cellular Response To UV Ribosome Biogenesis Positive Regulation Of Protein Catabolic Process Astrocyte Differentiation UV-damage Excision Repair Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle
Pathways		Neutrophil degranulation Neddylation Iron uptake and transport	Recognition of DNA damage by PCNA-containing replication complex DNA Damage Recognition in GG-NER Formation of Incision Complex in GG-NER Dual Incision in GG-NER Formation of TC-NER Pre-Incision Complex Transcription-Coupled Nucleotide Excision Repair (TC-NER) Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER Neddylation
Diseases		None	Syndromic X-linked mental retardation, including: Turner type (MRXST); Siderius type (MRXSSD) ; Cabezas type (MRXC); Raymond type (MRXSR); Type10 (MRXS10); Type14 (MRXS14); Mental retardation with isolated growth hormone deficiency (MRGH)
GWAS		Amyotrophic lateral sclerosis (C9orf72 mutation interaction) ( 22959728 ) Epstein-Barr virus copy number in lymphoblastoid cell lines ( 28654678 ) Expressive vocabulary in infants ( 25226531 ) HDL cholesterol levels ( 32203549 ) Hippocampal atrophy ( 19668339 ) Metabolite levels ( 23823483 ) Systolic blood pressure ( 30224653 ) Triglyceride levels ( 32203549 )	No GWAS studies recorded
Novel Interactors		1 novel interactors: CD28	2 novel interactors: PLS3 SRC
Interacting Genes		20 interacting genes: CA9 CEBPA CNOT3 CUL1 CUL2 CUL3 CUL4A CUL4B DCUN1D2 DCUN1D4 DCUN1D5 DUX4 FILNC1 HSPA13 MTNR1A RBX1 RNF10 SKP1 SRPK2 UBE2M	45 interacting genes: AHR APP AR BRWD1 BRWD3 CAND1 CDK1 COMMD1 COP1 COPS5 CSNK1A1 DCAF10 DCAF11 DCAF12 DCAF16 DCAF17 DCAF5 DCUN1D4 DDA1 DDB1 DDB2 DNMT3B ESR1 HDAC2 HDAC3 HUWE1 KPNA2 KPNA4 KPNB1 MTA2 NEDD8 PAFAH1B1 PLK1 PRDX3 PTEN PWP1 RBX1 SALL2 SIN3A SIRT1 ST7 TBL3 UBC UBE2D3 ZMAT4
Entrez ID		55832	8450
HPRD ID		06983	02251
Ensembl ID		ENSG00000111530	ENSG00000158290
Uniprot IDs		Q86VP6	K4DI93 Q13620
PDB IDs		1U6G 4A0C 7Z8R 7Z8T 7Z8V 7ZBW 7ZBZ 8CDJ 8CDK 8H3Q 8OR0 8OR2 8OR3 8OR4	2DO7 4A0C 4A0L 4A64 8EI1
GO Terms Enriched among Interactors		Cullin-RING Ubiquitin Ligase Complex Ubiquitin Ligase Complex Scaffold Activity Protein Modification By Small Protein Conjugation Post-translational Protein Modification Protein Neddylation Cullin Family Protein Binding G1/S Transition Of Mitotic Cell Cycle Cell Cycle G1/S Phase Transition Protein Modification Process Protein Monoubiquitination Ubiquitin-like Protein Binding Positive Regulation Of Protein Neddylation Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Proteasomal Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Metabolic Process Modification-dependent Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Via The C-end Degron Rule Pathway Protein Ubiquitination Protein Catabolic Process Positive Regulation Of Post-translational Protein Modification Cul4A-RING E3 Ubiquitin Ligase Complex Proteolysis Involved In Protein Catabolic Process SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process SCF Ubiquitin Ligase Complex Ubiquitin Protein Ligase Binding Macromolecule Catabolic Process Regulation Of Protein Neddylation Positive Regulation Of Epithelial Cell Apoptotic Process Regulation Of Protein Metabolic Process Positive Regulation Of Metabolic Process Protein Metabolic Process Cul4-RING E3 Ubiquitin Ligase Complex Nucleus Macromolecule Metabolic Process Protein K48-linked Ubiquitination Ubiquitin Conjugating Enzyme Binding Cul7-RING Ubiquitin Ligase Complex Regulation Of Post-translational Protein Modification Base-excision Repair, AP Site Formation Via Deaminated Base Removal NEDD8 Transferase Activity Protein Polyubiquitination Regulation Of Cell Cycle Cul4B-RING E3 Ubiquitin Ligase Complex Regulation Of Epithelial Cell Apoptotic Process Type I Interferon-mediated Signaling Pathway Apoptotic Signaling Pathway Positive Regulation Of Cell Cycle	Cul4-RING E3 Ubiquitin Ligase Complex Post-translational Protein Modification Protein Modification By Small Protein Conjugation Protein Modification Process Protein Ubiquitination Nucleoplasm Nucleus Macromolecule Metabolic Process Regulation Of Primary Metabolic Process Positive Regulation Of Proteolysis Positive Regulation Of Macromolecule Metabolic Process Regulation Of Proteolysis Protein Metabolic Process Rhythmic Process Regulation Of DNA-templated Transcription Positive Regulation Of Protein Metabolic Process Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Macromolecule Metabolic Process Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Catabolic Process Regulation Of Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Regulation Of Metabolic Process Cul4A-RING E3 Ubiquitin Ligase Complex Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Transcription By RNA Polymerase II Enzyme Binding Positive Regulation Of Protein Catabolic Process Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Gene Expression Histone Deacetylase Activity Proteolysis Involved In Protein Catabolic Process Regulation Of Protein Metabolic Process Ubiquitin-dependent Protein Catabolic Process Protein Neddylation Response To Hydrogen Peroxide Regulation Of Macromolecule Biosynthetic Process Nucleotide-excision Repair Cul4B-RING E3 Ubiquitin Ligase Complex Positive Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Signal Transduction Response To Oxidative Stress Proteasomal Protein Catabolic Process Regulation Of Protein Catabolic Process Protein-containing Complex