CUL4B and NEDD8

Number of citations of the paper that reports this interaction (PMID 16620772)
10

Data Source:
BioGRID (pull down, affinity chromatography technology)
HPRD (in vivo)

		CUL4B	NEDD8
Gene Name		cullin 4B	neural precursor cell expressed, developmentally down-regulated 8
Image
Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytoplasm Plasma Membrane Cul4B-RING E3 Ubiquitin Ligase Complex Extracellular Vesicular Exosome	Nucleus Cytosol Extracellular Vesicular Exosome
	Molecular Function	Damaged DNA Binding Protein Binding Ubiquitin Protein Ligase Binding	Protein Binding Ubiquitin Protein Ligase Binding
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Cell Cycle Histone H2A Monoubiquitination Positive Regulation Of Protein Catabolic Process UV-damage Excision Repair Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle	Regulation Of Transcription From RNA Polymerase II Promoter Cellular Protein Modification Process Proteolysis Ubiquitin-dependent Protein Catabolic Process Transforming Growth Factor Beta Receptor Signaling Pathway Protein Localization Anatomical Structure Morphogenesis Response To Organic Cyclic Compound Protein Neddylation
Pathways			Loss of Function of TGFBR2 in Cancer TGFBR2 MSI Frameshift Mutants in Cancer SMAD2/3 Phosphorylation Motif Mutants in Cancer Loss of Function of SMAD2/3 in Cancer TGFBR2 Kinase Domain Mutants in Cancer Loss of Function of SMAD4 in Cancer SMAD2/3 MH2 Domain Mutants in Cancer TGFBR1 KD Mutants in Cancer TGF-beta receptor signaling activates SMADs TGFBR1 LBD Mutants in Cancer Loss of Function of TGFBR1 in Cancer Signaling by TGF-beta Receptor Complex Signaling by TGF-beta Receptor Complex in Cancer SMAD4 MH2 Domain Mutants in Cancer
Drugs
Diseases
GWAS
Protein-Protein Interactions		22 interactors: AHR APP AR CAND1 COMMD1 DCUN1D1 DCUN1D3 DCUN1D4 DCUN1D5 DDB1 DDB2 DTL ESR1 KPNA2 KPNA4 KPNB1 NEDD8 RBX1 RNF7 SALL2 SIN3A UBC	34 interactors: AHR ANK1 ARIH1 ARIH2 CDC34 COPS5 COPS6 CTRC CUL1 CUL2 CUL3 CUL4B CUL5 DCUN1D1 DNMT3B NAE1 NPLOC4 NUB1 PARP1 PSMD4 PTK2 RPL11 SENP8 SMURF1 TP53 UBA2 UBA3 UBE2F UBE2K UBE2M UBXN7 UCHL1 UCHL3 UFD1L
Entrez ID		8450	4738
HPRD ID		02251	04412
Ensembl ID		ENSG00000158290	ENSG00000129559
Uniprot IDs		Q13620	Q15843
PDB IDs		2DO7 4A0C 4A0L 4A64	1NDD 1R4M 1R4N 1XT9 2BKR 2KO3 2NVU 3DBH 3DBL 3DBR 3DQV 3GZN 4F8C 4FBJ 4HCP
Enriched GO Terms of Interacting Partners?		Protein Modification By Small Protein Conjugation Protein Monoubiquitination Protein Neddylation Protein Ubiquitination Intracellular Receptor Signaling Pathway NLS-bearing Protein Import Into Nucleus Regulation Of Transcription From RNA Polymerase II Promoter DNA Metabolic Process Positive Regulation Of RNA Polymerase II Transcriptional Preinitiation Complex Assembly Response To UV Cellular Macromolecule Catabolic Process Response To Light Stimulus Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Regulation Of DNA-templated Transcription In Response To Stress Regulation Of RNA Polymerase II Transcriptional Preinitiation Complex Assembly UV-damage Excision Repair Positive Regulation Of Transcription From RNA Polymerase II Promoter Prostate Gland Development Response To Abiotic Stimulus Nucleobase-containing Compound Metabolic Process Regulation Of Mitotic Cell Cycle Phase Transition Response To Radiation Regulation Of Cell Cycle Phase Transition Histone H2A Monoubiquitination Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Transcription Initiation From RNA Polymerase II Promoter Modification-dependent Protein Catabolic Process Cellular Response To Stimulus Histone H2A Ubiquitination Cellular Nitrogen Compound Metabolic Process Positive Regulation Of DNA-templated Transcription, Initiation Viral Process Proteolysis Involved In Cellular Protein Catabolic Process Positive Regulation Of Transcription, DNA-templated Cellular Protein Catabolic Process Nucleotide-excision Repair, DNA Damage Removal Cellular Response To Organic Substance Rhythmic Process Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Protein Import Into Nucleus Histone Monoubiquitination DNA Repair Nuclear Import Regulation Of DNA-templated Transcription, Initiation Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Protein Catabolic Process Copper Ion Homeostasis Regulation Of Apoptotic Process	Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Protein Modification By Small Protein Conjugation Cellular Macromolecule Catabolic Process Proteolysis Cellular Protein Metabolic Process Protein Metabolic Process Cellular Protein Modification Process Protein Ubiquitination Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Protein Neddylation Cellular Metabolic Process G1/S Transition Of Mitotic Cell Cycle Protein Polyubiquitination Intrinsic Apoptotic Signaling Pathway Regulation Of Cell Cycle Metabolic Process Positive Regulation Of Protein Catabolic Process Protein Deneddylation Apoptotic Process Mitotic Cell Cycle Programmed Cell Death Regulation Of Protein Catabolic Process Cell Death Death Cell Cycle Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Cellular Protein Catabolic Process Cell Cycle Arrest Negative Regulation Of Cell Cycle Mitotic Cell Cycle Process Cellular Response To Transforming Growth Factor Beta Stimulus Response To Transforming Growth Factor Beta Apoptotic Signaling Pathway Viral Process Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Cell Cycle Phase Transition Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Protein K48-linked Ubiquitination Protein Modification By Small Protein Removal Protein Monoubiquitination Positive Regulation Of Proteolysis
Tagcloud ?		absent alleviate assemble augmented blunted dampening depleted downregulated drives driving e3 ectopic exacerbate feedback greatly h2o2 ligases loop mildly negatively nhfs oxidative proteosomal replicative ros senescence senescent stressed ubiquitination	activate activates activating analyze app appbp1 covalently cullin discuss downregulates driven existing gradual gradually hypothesize insights integrity investigation ligases lost modifies neddylation precursor protects reverse slow switches turnover ubiquitin
Tagcloud (Difference) ?		absent alleviate assemble augmented blunted dampening depleted downregulated drives driving e3 ectopic exacerbate feedback greatly h2o2 loop mildly negatively nhfs oxidative proteosomal replicative ros senescence senescent stressed ubiquitination	activate activates activating analyze app appbp1 covalently cullin discuss downregulates driven existing gradual gradually hypothesize insights integrity investigation lost modifies neddylation precursor protects reverse slow switches turnover ubiquitin
Tagcloud (Intersection) ?		ligases