CUL4B and ZMAT4

Number of citations: 47 (PubMedID 25910212)
Data Source: BioGRID (two hybrid)

		CUL4B	ZMAT4
Name		cullin 4B	zinc finger matrin-type 4
Structure			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Cullin-RING Ubiquitin Ligase Complex Cul4A-RING E3 Ubiquitin Ligase Complex Cul4B-RING E3 Ubiquitin Ligase Complex Extracellular Exosome Cul4-RING E3 Ubiquitin Ligase Complex	Nucleus
	Molecular Function	Damaged DNA Binding Protein Binding Ubiquitin Protein Ligase Binding	Nucleic Acid Binding DNA Binding Protein Binding Zinc Ion Binding Identical Protein Binding Metal Ion Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Protein Polyubiquitination DNA Repair Ubiquitin-dependent Protein Catabolic Process DNA Damage Response Gene Expression Proteasomal Protein Catabolic Process Protein Ubiquitination Cellular Response To UV Ribosome Biogenesis Positive Regulation Of Protein Catabolic Process Astrocyte Differentiation UV-damage Excision Repair Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle	None
Pathways		Recognition of DNA damage by PCNA-containing replication complex DNA Damage Recognition in GG-NER Formation of Incision Complex in GG-NER Dual Incision in GG-NER Formation of TC-NER Pre-Incision Complex Transcription-Coupled Nucleotide Excision Repair (TC-NER) Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER Neddylation	None
Diseases		Syndromic X-linked mental retardation, including: Turner type (MRXST); Siderius type (MRXSSD) ; Cabezas type (MRXC); Raymond type (MRXSR); Type10 (MRXS10); Type14 (MRXS14); Mental retardation with isolated growth hormone deficiency (MRGH)	None
GWAS		No GWAS studies recorded	Body fat mass ( 28552196 ) Brain volume in infants (grey matter) ( 28763065 ) Coffee consumption ( 31046077 ) Fasting plasma glucose ( 17903298 ) Forced expiratory volume in 1 second (occupational environmental exposures interaction) ( 25979521 ) Hip circumference ( 28552196 ) Iris color (L* coordinate) ( 30895295 ) Lung cancer ( 28604730 ) Myopia ( 27182965 ) Pediatric areal bone mineral density (concordant skeletal phenotype) ( 29240982 ) Refractive error ( 23396134 32231278 ) Severe aplastic anemia ( 32004448 ) Spherical equivalent (joint analysis main effects and education interaction) ( 27020472 ) Spherical equivalent or myopia (age of diagnosis) ( 29808027 ) Waist circumference ( 28552196 )
Interacting Genes		45 interacting genes: AHR APP AR BRWD1 BRWD3 CAND1 CDK1 COMMD1 COP1 COPS5 CSNK1A1 DCAF10 DCAF11 DCAF12 DCAF16 DCAF17 DCAF5 DCUN1D4 DDA1 DDB1 DDB2 DNMT3B ESR1 HDAC2 HDAC3 HUWE1 KPNA2 KPNA4 KPNB1 MTA2 NEDD8 PAFAH1B1 PLK1 PRDX3 PTEN PWP1 RBX1 SALL2 SIN3A SIRT1 ST7 TBL3 UBC UBE2D3 ZMAT4	9 interacting genes: ADARB1 APP CUL3 CUL4B DAPK1 LRSAM1 SRPK2 STRBP TARBP2
Entrez ID		8450	79698
HPRD ID		02251	07837
Ensembl ID		ENSG00000158290	ENSG00000165061
Uniprot IDs		K4DI93 Q13620	Q9H898
PDB IDs		2DO7 4A0C 4A0L 4A64 8EI1	Not available
GO Terms Enriched among Interactors		Cul4-RING E3 Ubiquitin Ligase Complex Post-translational Protein Modification Protein Modification By Small Protein Conjugation Protein Modification Process Protein Ubiquitination Nucleoplasm Nucleus Macromolecule Metabolic Process Regulation Of Primary Metabolic Process Positive Regulation Of Proteolysis Positive Regulation Of Macromolecule Metabolic Process Regulation Of Proteolysis Protein Metabolic Process Rhythmic Process Regulation Of DNA-templated Transcription Positive Regulation Of Protein Metabolic Process Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Macromolecule Metabolic Process Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Catabolic Process Regulation Of Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Regulation Of Metabolic Process Cul4A-RING E3 Ubiquitin Ligase Complex Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Transcription By RNA Polymerase II Enzyme Binding Positive Regulation Of Protein Catabolic Process Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Gene Expression Histone Deacetylase Activity Proteolysis Involved In Protein Catabolic Process Regulation Of Protein Metabolic Process Ubiquitin-dependent Protein Catabolic Process Protein Neddylation Response To Hydrogen Peroxide Regulation Of Macromolecule Biosynthetic Process Nucleotide-excision Repair Cul4B-RING E3 Ubiquitin Ligase Complex Positive Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Signal Transduction Response To Oxidative Stress Proteasomal Protein Catabolic Process Regulation Of Protein Catabolic Process Protein-containing Complex	Positive Regulation Of Viral Genome Replication Double-stranded RNA Binding Regulation Of Viral Genome Replication Positive Regulation Of Viral Process Regulation Of Cell Cycle Protein Polyubiquitination Positive Regulation Of Cell Cycle Regulation Of Viral Life Cycle Cullin-RING Ubiquitin Ligase Complex Positive Regulation Of Mitotic Cell Cycle Regulation Of Viral Process Regulation Of Protein Metabolic Process Macromolecule Metabolic Process Protein Modification Process Regulation Of Mitotic Cell Cycle Identical Protein Binding Positive Regulation Of Catabolic Process Protein Ubiquitination Protein Metabolic Process Defense Response Hypoglossal Nerve Morphogenesis Regulation Of Metabolic Process Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway DAPK1-calmodulin Complex Positive Regulation Of Autophagic Cell Death Regulation Of SiRNA Processing Protein Modification By Small Protein Conjugation Positive Regulation Of Neuron Apoptotic Process Protein Autoubiquitination Negative Regulation Of Protein Kinase Activity Positive Regulation Of Protein Metabolic Process Nucleus Positive Regulation Of Metabolic Process Negative Regulation Of Kinase Activity Post-translational Protein Modification Developmental Growth Regulation Of Primary Metabolic Process Acetylcholine Receptor Activator Activity Lipoprotein Particle Positive Regulation Of Protein Import Cell Cycle G1/S Phase Transition G1/S Transition Of Mitotic Cell Cycle Trophectodermal Cellular Morphogenesis Liver Morphogenesis Apoptotic Process Negative Regulation Of Protein Phosphorylation