CUL4B and DCAF16

Number of citations: 97 (PubMedID 33961781)
Data Source: BioGRID (affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology)

		CUL4B	DCAF16
Name		cullin 4B	DDB1 and CUL4 associated factor 16
Structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Cullin-RING Ubiquitin Ligase Complex Cul4A-RING E3 Ubiquitin Ligase Complex Cul4B-RING E3 Ubiquitin Ligase Complex Extracellular Exosome Cul4-RING E3 Ubiquitin Ligase Complex	Nucleus Nucleoplasm Cul4-RING E3 Ubiquitin Ligase Complex
	Molecular Function	Damaged DNA Binding Protein Binding Ubiquitin Protein Ligase Binding	Protein Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Protein Polyubiquitination DNA Repair Ubiquitin-dependent Protein Catabolic Process DNA Damage Response Gene Expression Proteasomal Protein Catabolic Process Protein Ubiquitination Cellular Response To UV Ribosome Biogenesis Positive Regulation Of Protein Catabolic Process Astrocyte Differentiation UV-damage Excision Repair Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle	Protein Ubiquitination
Pathways		Recognition of DNA damage by PCNA-containing replication complex DNA Damage Recognition in GG-NER Formation of Incision Complex in GG-NER Dual Incision in GG-NER Formation of TC-NER Pre-Incision Complex Transcription-Coupled Nucleotide Excision Repair (TC-NER) Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER Neddylation	Neddylation
Diseases		Syndromic X-linked mental retardation, including: Turner type (MRXST); Siderius type (MRXSSD) ; Cabezas type (MRXC); Raymond type (MRXSR); Type10 (MRXS10); Type14 (MRXS14); Mental retardation with isolated growth hormone deficiency (MRGH)	None
GWAS		No GWAS studies recorded	Birth weight ( 31043758 ) Height ( 34270706 ) Hip circumference adjusted for BMI ( 34021172 ) Offspring birth weight ( 31043758 )
Interacting Genes		45 interacting genes: AHR APP AR BRWD1 BRWD3 CAND1 CDK1 COMMD1 COP1 COPS5 CSNK1A1 DCAF10 DCAF11 DCAF12 DCAF16 DCAF17 DCAF5 DCUN1D4 DDA1 DDB1 DDB2 DNMT3B ESR1 HDAC2 HDAC3 HUWE1 KPNA2 KPNA4 KPNB1 MTA2 NEDD8 PAFAH1B1 PLK1 PRDX3 PTEN PWP1 RBX1 SALL2 SIN3A SIRT1 ST7 TBL3 UBC UBE2D3 ZMAT4	3 interacting genes: CUL4B PRMT1 PRMT6
Entrez ID		8450	54876
HPRD ID		02251	07891
Ensembl ID		ENSG00000158290	ENSG00000163257
Uniprot IDs		K4DI93 Q13620	Q9NXF7
PDB IDs		2DO7 4A0C 4A0L 4A64 8EI1	8G46 8OV6
GO Terms Enriched among Interactors		Cul4-RING E3 Ubiquitin Ligase Complex Post-translational Protein Modification Protein Modification By Small Protein Conjugation Protein Modification Process Protein Ubiquitination Nucleoplasm Nucleus Macromolecule Metabolic Process Regulation Of Primary Metabolic Process Positive Regulation Of Proteolysis Positive Regulation Of Macromolecule Metabolic Process Regulation Of Proteolysis Protein Metabolic Process Rhythmic Process Regulation Of DNA-templated Transcription Positive Regulation Of Protein Metabolic Process Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Macromolecule Metabolic Process Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Catabolic Process Regulation Of Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Regulation Of Metabolic Process Cul4A-RING E3 Ubiquitin Ligase Complex Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Transcription By RNA Polymerase II Enzyme Binding Positive Regulation Of Protein Catabolic Process Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Gene Expression Histone Deacetylase Activity Proteolysis Involved In Protein Catabolic Process Regulation Of Protein Metabolic Process Ubiquitin-dependent Protein Catabolic Process Protein Neddylation Response To Hydrogen Peroxide Regulation Of Macromolecule Biosynthetic Process Nucleotide-excision Repair Cul4B-RING E3 Ubiquitin Ligase Complex Positive Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Signal Transduction Response To Oxidative Stress Proteasomal Protein Catabolic Process Regulation Of Protein Catabolic Process Protein-containing Complex	Protein-arginine Omega-N Monomethyltransferase Activity Histone H4R3 Methyltransferase Activity Protein-arginine Omega-N Asymmetric Methyltransferase Activity Protein-arginine N-methyltransferase Activity Histone Methyltransferase Activity Regulation Of Megakaryocyte Differentiation DNA Repair DNA Metabolic Process DNA Damage Response GATOR1 Complex Binding Histone H2AR3 Methyltransferase Activity Methyltransferase Activity Histone H3R2 Methyltransferase Activity Methylation Regulation Of Myeloid Cell Differentiation Histone Arginine N-methyltransferase Activity N-methyltransferase Activity Regulation Of Protein Metabolic Process Cellular Response To Stress Positive Regulation Of Hemoglobin Biosynthetic Process Peptidyl-arginine Methylation Regulation Of Hemoglobin Biosynthetic Process Mitogen-activated Protein Kinase P38 Binding Response To Methionine Histone H4 Methyltransferase Activity Cellular Response To Methionine Cul4B-RING E3 Ubiquitin Ligase Complex Nucleic Acid Metabolic Process Regulation Of Hemopoiesis UV-damage Excision Repair Methylosome Protein Methyltransferase Activity Cul4A-RING E3 Ubiquitin Ligase Complex Cullin-RING Ubiquitin Ligase Complex Nucleobase-containing Compound Metabolic Process Negative Regulation Of Megakaryocyte Differentiation Negative Regulation Of Protein Metabolic Process S-adenosyl-L-methionine Binding Chromatin Remodeling Histone H3 Methyltransferase Activity Methyl-CpG Binding Viral Protein Processing Negative Regulation Of Double-strand Break Repair Via Homologous Recombination Positive Regulation Of P38MAPK Cascade Cul4-RING E3 Ubiquitin Ligase Complex Astrocyte Differentiation Positive Regulation Of Protein Metabolic Process Protein Methylation Negative Regulation Of JNK Cascade Positive Regulation Of Erythrocyte Differentiation