CUL4B and BRWD3

Number of citations of the paper that reports this interaction (PubMedID 31753913)
116

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, pull down)

		CUL4B	BRWD3
Description		cullin 4B	bromodomain and WD repeat domain containing 3
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Cullin-RING Ubiquitin Ligase Complex Cul4A-RING E3 Ubiquitin Ligase Complex Cul4B-RING E3 Ubiquitin Ligase Complex Extracellular Exosome Cul4-RING E3 Ubiquitin Ligase Complex	Nucleus
	Molecular Function	Damaged DNA Binding Protein Binding Ubiquitin Protein Ligase Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Protein Polyubiquitination DNA Repair Ubiquitin-dependent Protein Catabolic Process DNA Damage Response Gene Expression Proteasomal Protein Catabolic Process Protein Ubiquitination Cellular Response To UV Ribosome Biogenesis Positive Regulation Of Protein Catabolic Process Astrocyte Differentiation UV-damage Excision Repair Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle	Regulation Of Transcription By RNA Polymerase II Cytoskeleton Organization Regulation Of Cell Shape
Pathways		Recognition of DNA damage by PCNA-containing replication complex DNA Damage Recognition in GG-NER Formation of Incision Complex in GG-NER Dual Incision in GG-NER Formation of TC-NER Pre-Incision Complex Transcription-Coupled Nucleotide Excision Repair (TC-NER) Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER Neddylation
Drugs
Diseases		Syndromic X-linked mental retardation, including: Turner type (MRXST); Siderius type (MRXSSD) ; Cabezas type (MRXC); Raymond type (MRXSR); Type10 (MRXS10); Type14 (MRXS14); Mental retardation with isolated growth hormone deficiency (MRGH)
GWAS			Photic sneeze reflex ( 27182965)
Interacting Genes		45 interacting genes: AHR APP AR BRWD1 BRWD3 CAND1 CDK1 COMMD1 COP1 COPS5 CSNK1A1 DCAF10 DCAF11 DCAF12 DCAF16 DCAF17 DCAF5 DCUN1D4 DDA1 DDB1 DDB2 DNMT3B ESR1 HDAC2 HDAC3 HUWE1 KPNA2 KPNA4 KPNB1 MTA2 NEDD8 PAFAH1B1 PLK1 PRDX3 PTEN PWP1 RBX1 SALL2 SIN3A SIRT1 ST7 TBL3 UBC UBE2D3 ZMAT4	3 interacting genes: CUL4B DDB1 ITSN1
Entrez ID		8450	254065
HPRD ID		02251	06564
Ensembl ID		ENSG00000158290	ENSG00000165288
Uniprot IDs		K4DI93 Q13620	Q6RI45
PDB IDs		2DO7 4A0C 4A0L 4A64 8EI1
Enriched GO Terms of Interacting Partners?		Cul4-RING E3 Ubiquitin Ligase Complex Post-translational Protein Modification Protein Modification By Small Protein Conjugation Protein Modification Process Protein Ubiquitination Nucleoplasm Nucleus Macromolecule Metabolic Process Regulation Of Primary Metabolic Process Positive Regulation Of Proteolysis Positive Regulation Of Macromolecule Metabolic Process Regulation Of Proteolysis Protein Metabolic Process Rhythmic Process Regulation Of DNA-templated Transcription Positive Regulation Of Protein Metabolic Process Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Macromolecule Metabolic Process Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Catabolic Process Regulation Of Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Regulation Of Metabolic Process Cul4A-RING E3 Ubiquitin Ligase Complex Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Transcription By RNA Polymerase II Enzyme Binding Positive Regulation Of Protein Catabolic Process Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Gene Expression Histone Deacetylase Activity Proteolysis Involved In Protein Catabolic Process Regulation Of Protein Metabolic Process Ubiquitin-dependent Protein Catabolic Process Protein Neddylation Response To Hydrogen Peroxide Regulation Of Macromolecule Biosynthetic Process Nucleotide-excision Repair Cul4B-RING E3 Ubiquitin Ligase Complex Positive Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Signal Transduction Response To Oxidative Stress Proteasomal Protein Catabolic Process Regulation Of Protein Catabolic Process Protein-containing Complex	Cul4B-RING E3 Ubiquitin Ligase Complex UV-damage Excision Repair Cul4A-RING E3 Ubiquitin Ligase Complex Cul4-RING E3 Ubiquitin Ligase Complex Damaged DNA Binding Cellular Response To UV Cellular Response To Light Stimulus Response To UV Cellular Response To Radiation Clathrin-dependent Synaptic Vesicle Endocytosis Protein-macromolecule Adaptor Activity Positive Regulation Of Protein Catabolic Process Positive Regulation By Virus Of Viral Protein Levels In Host Cell Positive Regulation Of Caveolin-mediated Endocytosis Base-excision Repair, AP Site Formation Via Deaminated Base Removal WD40-repeat Domain Binding Response To Light Stimulus Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Caveolin-mediated Endocytosis Regulation Of Modification Of Postsynaptic Actin Cytoskeleton Ubiquitin Ligase Complex Scaffold Activity Regulation Of Protein Catabolic Process Postsynaptic Endocytic Zone Positive Regulation Of Growth Hormone Secretion Postsynaptic Actin Cytoskeleton Response To Radiation Regulation Of Cell Cycle Phase Transition Regulation Of Mitotic Cell Cycle Spindle Assembly Involved In Female Meiosis Meiotic Spindle Assembly DNA Repair Proteasomal Protein Catabolic Process Epigenetic Programming In The Zygotic Pronuclei Regulation Of Growth Hormone Secretion Regulation Of Modification Of Postsynaptic Structure Cullin-RING Ubiquitin Ligase Complex Base-excision Repair, AP Site Formation Apical Dendrite Modification-dependent Protein Catabolic Process Ectopic Germ Cell Programmed Cell Death Positive Regulation Of Catabolic Process Ubiquitin-dependent Protein Catabolic Process Proline-rich Region Binding Intracellular Vesicle Regulation Of Modification Of Synaptic Structure Protein Catabolic Process Programmed Cell Death Involved In Cell Development Meiotic Spindle Organization Protein Ubiquitination Positive Regulation Of Gluconeogenesis
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