CASQ2 and ANKRD1

Number of citations of the paper that reports this interaction (PubMedID 15698842)
0

Data Source:
HPRD (in vitro)

		CASQ2	ANKRD1
Description		calsequestrin 2	ankyrin repeat domain 1
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Junctional Sarcoplasmic Reticulum Membrane Sarcoplasmic Reticulum Z Disc Sarcoplasmic Reticulum Membrane Sarcoplasmic Reticulum Lumen Calcium Channel Complex	Fibrillar Center Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm Cytosol Myofibril I Band Protein-containing Complex
	Molecular Function	Calcium Ion Binding Protein Binding Protein Homodimerization Activity Metal Ion Binding Calcium-dependent Protein Binding Calcium Ion Sequestering Activity	P53 Binding DNA Binding Transcription Coregulator Activity Transcription Coactivator Activity Transcription Corepressor Activity Protein Binding Titin Binding Histone Deacetylase Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding R-SMAD Binding
	Biological Process	Regulation Of Heart Rate Detection Of Calcium Ion Intracellular Calcium Ion Homeostasis Striated Muscle Contraction Regulation Of Cell Communication By Electrical Coupling Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Negative Regulation Of Potassium Ion Transport Sequestering Of Calcium Ion Protein Polymerization Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Cardiac Muscle Contraction Regulation Of Membrane Repolarization Cellular Response To Caffeine Purkinje Myocyte To Ventricular Cardiac Muscle Cell Signaling Regulation Of Membrane Repolarization During Ventricular Cardiac Muscle Cell Action Potential	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Neuron Projection Development Skeletal Muscle Cell Differentiation Response To Muscle Stretch Positive Regulation Of Apoptotic Process Positive Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Sarcomere Organization Positive Regulation Of DNA-templated Transcription Positive Regulation Of Protein Secretion Cardiac Muscle Tissue Morphogenesis Cellular Response To Lipopolysaccharide Cellular Response To Mechanical Stimulus Cellular Response To Interleukin-1 Cellular Response To Tumor Necrosis Factor Cellular Response To Hypoxia Cellular Response To Xenobiotic Stimulus Cellular Response To Transforming Growth Factor Beta Stimulus Phospholipase C/protein Kinase C Signal Transduction Negative Regulation Of DNA Biosynthetic Process
Pathways		Stimuli-sensing channels Ion homeostasis	PPARA activates gene expression
Drugs		Calcium citrate Calcium Phosphate Calcium phosphate dihydrate
Diseases		Catecholaminergic polymorphic ventricular tachycardia
GWAS		Atrial fibrillation ( 29892015 30061737) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Left ventricle wall thickness ( 33495596) Left ventricular global radial strain ( 33495596) Pulse pressure ( 30578418) QRS duration ( 27577874 27659466 30012220)	Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Intraocular pressure ( 29617998) Refractive error ( 32231278)
Interacting Genes		6 interacting genes: ANKRD1 CFTR CSNK2A1 CSNK2A2 FBXO7 TRDN	23 interacting genes: APPL1 ARHGDIB ASH2L CASQ2 CDCA7L DNAJB6 DST DYSF LRPPRC MAPRE3 MEOX2 MYBPC1 MYL1 MYOM2 MYPN NAGK REPS1 SPANXN2 TRIM55 TRIM63 TTN TULP3 ZNF446
Entrez ID		845	27063
HPRD ID		00256	10647
Ensembl ID		ENSG00000118729	ENSG00000148677
Uniprot IDs		O14958	A0A384NYH5 Q15327
PDB IDs		2VAF 6OWV 6OWW 7F05
Enriched GO Terms of Interacting Partners?		Protein Kinase CK2 Complex PcG Protein Complex Regulation Of Macroautophagy Negative Regulation Of Apoptotic Signaling Pathway Regulation Of Cell Communication Positive Regulation Of Establishment Of Protein Localization Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Autophagy Of Mitochondrion Regulation Of Mitophagy Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Apoptotic Signaling Pathway Negative Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Regulation Of Autophagy Regulation Of Chromosome Separation Glial Cytoplasmic Inclusion Classical Lewy Body Lewy Body Corona Lewy Neurite Positive Regulation Of Macroautophagy Regulation Of Establishment Of Protein Localization Positive Regulation Of Anion Channel Activity Regulation Of Programmed Cell Death Regulation Of Apoptotic Process Regulation Of Signal Transduction By P53 Class Mediator Negative Regulation Of Protein Catabolic Process Positive Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction Cellular Response To Stress Positive Regulation Of Monoatomic Anion Transport Positive Regulation Of Protein Secretion Cytosol Negative Regulation Of DNA Metabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Chromosome Segregation Negative Regulation Of Proteolysis Symbiont-mediated Disruption Of Host Cell PML Body Positive Regulation Of Cell Communication By Electrical Coupling Lewy Body Core Positive Regulation Of Enamel Mineralization Regulation Of Cell Cycle Process Positive Regulation Of Cell Communication Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Autophagy Protein-containing Complex Regulation Of Signaling Transepithelial Water Transport Positive Regulation Of Aggrephagy	Z Disc M Band Sarcomere Organization Structural Constituent Of Muscle Muscle Contraction Actin Filament-based Process Actomyosin Structure Organization Muscle System Process Microtubule Actin Cytoskeleton Organization Calcium Ion Binding Titin Binding Contractile Muscle Fiber Muscle Filament Sliding Muscle Alpha-actinin Binding Cytoskeleton Organization Actin-myosin Filament Sliding Microtubule Plus-end Binding Negative Regulation Of Phagocytosis Myosin Filament Microtubule Plus-end I Band Calcium Ion Sequestering Activity Actin-mediated Cell Contraction Monocyte Activation Involved In Immune Response Negative Regulation Of Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis N-acetylglucosamine Kinase Activity Muramyl Dipeptide Kinase Activity Beta-tubulin Binding Cardiac Muscle Contraction Structural Molecule Activity H Zone Purkinje Myocyte To Ventricular Cardiac Muscle Cell Signaling Limb Development Myofibril Sarcomere Titin-telethonin Complex Structural Molecule Activity Conferring Elasticity Condensed Nuclear Chromosome Sarcomerogenesis Bronchus Morphogenesis Negative Regulation Of Mitochondrial MRNA Catabolic Process Negative Regulation Of Mitochondrial RNA Catabolic Process Positive Regulation Of Macropinocytosis N-acylmannosamine Kinase Activity N-acetylmannosamine Metabolic Process Response To Electrical Stimulus Involved In Regulation Of Muscle Adaptation
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