CASQ2

Name	calsequestrin 2
Structure
Interactors	6 interactors: ANKRD1 CFTR CSNK2A1 CSNK2A2 FBXO7 TRDN
GO Annotations	Cellular Component	Cytoplasm Junctional Sarcoplasmic Reticulum Membrane Sarcoplasmic Reticulum Z Disc Sarcoplasmic Reticulum Membrane Sarcoplasmic Reticulum Lumen Calcium Channel Complex
	Molecular Function	Calcium Ion Binding Protein Binding Protein Homodimerization Activity Metal Ion Binding Calcium-dependent Protein Binding Calcium Ion Sequestering Activity
	Biological Process	Regulation Of Heart Rate Detection Of Calcium Ion Intracellular Calcium Ion Homeostasis Striated Muscle Contraction Regulation Of Cell Communication By Electrical Coupling Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Negative Regulation Of Potassium Ion Transport Sequestering Of Calcium Ion Protein Polymerization Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Cardiac Muscle Contraction Regulation Of Membrane Repolarization Cellular Response To Caffeine Purkinje Myocyte To Ventricular Cardiac Muscle Cell Signaling Regulation Of Membrane Repolarization During Ventricular Cardiac Muscle Cell Action Potential
Pathways	Stimuli-sensing channels Ion homeostasis
Drugs	Calcium citrate Calcium Phosphate Calcium phosphate dihydrate
Diseases	Catecholaminergic polymorphic ventricular tachycardia
GWAS	Atrial fibrillation ( 29892015 30061737 ) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098 ) Left ventricle wall thickness ( 33495596 ) Left ventricular global radial strain ( 33495596 ) Pulse pressure ( 30578418 ) QRS duration ( 27577874 27659466 30012220 )
Entrez ID	845
HPRD ID	00256
Ensembl ID	ENSG00000118729
Uniprot IDs	O14958
PDB IDs	2VAF 6OWV 6OWW 7F05
GO Terms Enriched among Interactors ?	Protein Kinase CK2 Complex PcG Protein Complex Regulation Of Macroautophagy Negative Regulation Of Apoptotic Signaling Pathway Regulation Of Cell Communication Positive Regulation Of Establishment Of Protein Localization Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Autophagy Of Mitochondrion Regulation Of Mitophagy Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Apoptotic Signaling Pathway Negative Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Regulation Of Autophagy Regulation Of Chromosome Separation Glial Cytoplasmic Inclusion Classical Lewy Body Lewy Body Corona Lewy Neurite Positive Regulation Of Macroautophagy Regulation Of Establishment Of Protein Localization Positive Regulation Of Anion Channel Activity Regulation Of Programmed Cell Death Regulation Of Apoptotic Process Regulation Of Signal Transduction By P53 Class Mediator Negative Regulation Of Protein Catabolic Process Positive Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction Cellular Response To Stress Positive Regulation Of Monoatomic Anion Transport Positive Regulation Of Protein Secretion Cytosol Negative Regulation Of DNA Metabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Chromosome Segregation Negative Regulation Of Proteolysis Symbiont-mediated Disruption Of Host Cell PML Body Positive Regulation Of Cell Communication By Electrical Coupling Lewy Body Core Positive Regulation Of Enamel Mineralization Regulation Of Cell Cycle Process Positive Regulation Of Cell Communication Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Autophagy Protein-containing Complex Regulation Of Signaling Transepithelial Water Transport Positive Regulation Of Aggrephagy