CASQ2 and TRDN

Number of citations: 0 (PubMedID 11069905)
Data Source: HPRD (in vitro, in vivo)

		CASQ2	TRDN
Name		calsequestrin 2	triadin
Structure			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Junctional Sarcoplasmic Reticulum Membrane Sarcoplasmic Reticulum Z Disc Sarcoplasmic Reticulum Membrane Sarcoplasmic Reticulum Lumen Calcium Channel Complex	Nucleoplasm Endoplasmic Reticulum Cytosol Plasma Membrane Junctional Sarcoplasmic Reticulum Membrane Membrane Sarcoplasmic Reticulum Junctional Membrane Complex Sarcoplasmic Reticulum Membrane Sarcoplasmic Reticulum Lumen
	Molecular Function	Calcium Ion Binding Protein Binding Protein Homodimerization Activity Metal Ion Binding Calcium-dependent Protein Binding Calcium Ion Sequestering Activity	Signaling Receptor Binding Protein Binding Protein-macromolecule Adaptor Activity Transmembrane Transporter Binding
	Biological Process	Regulation Of Heart Rate Detection Of Calcium Ion Intracellular Calcium Ion Homeostasis Striated Muscle Contraction Regulation Of Cell Communication By Electrical Coupling Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Negative Regulation Of Potassium Ion Transport Sequestering Of Calcium Ion Protein Polymerization Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Cardiac Muscle Contraction Regulation Of Membrane Repolarization Cellular Response To Caffeine Purkinje Myocyte To Ventricular Cardiac Muscle Cell Signaling Regulation Of Membrane Repolarization During Ventricular Cardiac Muscle Cell Action Potential	Intracellular Calcium Ion Homeostasis Muscle Contraction Response To Bacterium Regulation Of Cell Communication By Electrical Coupling Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Cytoplasmic Microtubule Organization Regulation Of Sequestering Of Calcium Ion Establishment Of Localization In Cell Heart Contraction Regulation Of Cardiac Muscle Cell Membrane Potential Endoplasmic Reticulum Membrane Organization Positive Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction
Pathways		Stimuli-sensing channels Ion homeostasis	Stimuli-sensing channels Ion homeostasis
Drugs		Calcium citrate Calcium Phosphate Calcium phosphate dihydrate	None
Diseases		Catecholaminergic polymorphic ventricular tachycardia	None
GWAS		Atrial fibrillation ( 29892015 30061737 ) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098 ) Left ventricle wall thickness ( 33495596 ) Left ventricular global radial strain ( 33495596 ) Pulse pressure ( 30578418 ) QRS duration ( 27577874 27659466 30012220 )	Asthma exacerbations in inhaled corticosteroid treatment ( 30697902 ) Borderline personality disorder ( 28632202 ) Cerebral amyloid deposition in APOEe4 non-carriers (PET imaging) ( 26252872 ) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098 ) Hypertrophic cardiomyopathy (sarcomere negative) ( 33495597 ) Intraocular pressure ( 30591961 ) Metabolite levels ( 23823483 ) Nickel levels ( 26025379 ) Night sleep phenotypes ( 27126917 ) Post bronchodilator FEV1 ( 26634245 )
Interacting Genes		6 interacting genes: ANKRD1 CFTR CSNK2A1 CSNK2A2 FBXO7 TRDN	10 interacting genes: ASPH CALM1 CASQ1 CASQ2 HRC KCNE4 PPIB PTPRN RYR1 SOCS3
Entrez ID		845	10345
HPRD ID		00256	04474
Ensembl ID		ENSG00000118729	ENSG00000186439
Uniprot IDs		O14958	A0A590UJV0 H9ME53 Q13061 Q8IVK2
PDB IDs		2VAF 6OWV 6OWW 7F05	Not available
GO Terms Enriched among Interactors		Protein Kinase CK2 Complex PcG Protein Complex Regulation Of Macroautophagy Negative Regulation Of Apoptotic Signaling Pathway Regulation Of Cell Communication Positive Regulation Of Establishment Of Protein Localization Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Autophagy Of Mitochondrion Regulation Of Mitophagy Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Apoptotic Signaling Pathway Negative Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Regulation Of Autophagy Regulation Of Chromosome Separation Glial Cytoplasmic Inclusion Classical Lewy Body Lewy Body Corona Lewy Neurite Positive Regulation Of Macroautophagy Regulation Of Establishment Of Protein Localization Positive Regulation Of Anion Channel Activity Regulation Of Programmed Cell Death Regulation Of Apoptotic Process Regulation Of Signal Transduction By P53 Class Mediator Negative Regulation Of Protein Catabolic Process Positive Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction Cellular Response To Stress Positive Regulation Of Monoatomic Anion Transport Positive Regulation Of Protein Secretion Cytosol Negative Regulation Of DNA Metabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Chromosome Segregation Negative Regulation Of Proteolysis Symbiont-mediated Disruption Of Host Cell PML Body Positive Regulation Of Cell Communication By Electrical Coupling Lewy Body Core Positive Regulation Of Enamel Mineralization Regulation Of Cell Cycle Process Positive Regulation Of Cell Communication Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Autophagy Protein-containing Complex Regulation Of Signaling Transepithelial Water Transport Positive Regulation Of Aggrephagy	Sarcoplasmic Reticulum Lumen Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Regulation Of Sequestering Of Calcium Ion Regulation Of Cell Communication By Electrical Coupling Calcium-mediated Signaling Sarcoplasmic Reticulum Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Calcium Channel Complex Regulation Of Striated Muscle Contraction Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Sarcoplasmic Reticulum Membrane Regulation Of Calcium Ion Transmembrane Transport Junctional Sarcoplasmic Reticulum Membrane Regulation Of Muscle Contraction Regulation Of Heart Contraction Detection Of Calcium Ion Regulation Of Calcium Ion Transport Regulation Of Cardiac Muscle Contraction Regulation Of Muscle System Process Regulation Of Blood Circulation Smooth Endoplasmic Reticulum Regulation Of Monoatomic Cation Transmembrane Transport Regulation Of System Process Regulation Of Heart Rate Regulation Of Monoatomic Ion Transmembrane Transport Calcium Ion Binding Regulation Of Metal Ion Transport Response To Calcium Ion Z Disc Transmembrane Transporter Binding Regulation Of Monoatomic Ion Transport Terminal Cisterna Intracellular Signaling Cassette Intracellular Calcium Ion Homeostasis Muscle Contraction Regulation Of Cytosolic Calcium Ion Concentration Positive Regulation Of Store-operated Calcium Channel Activity Calcium Ion Homeostasis Muscle System Process Intracellular Signal Transduction Regulation Of Monoatomic Ion Transmembrane Transporter Activity Regulation Of Transmembrane Transporter Activity Cellular Response To Caffeine Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction Cellular Response To Purine-containing Compound Response To Metal Ion Response To Caffeine Detection Of Chemical Stimulus Intracellular Monoatomic Cation Homeostasis