DOC2A and STXBP1

Number of citations of the paper that reports this interaction (PMID 9115738)
35

Data Source:
HPRD (two hybrid, in vivo, in vitro)

		DOC2A	STXBP1
Gene Name		double C2-like domains, alpha	syntaxin binding protein 1
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Lysosome Cell Junction Synaptic Vesicle Membrane Neuron Projection	Nucleoplasm Cytoplasm Mitochondrion Cytosol Plasma Membrane Platelet Alpha Granule Protein Complex Extracellular Vesicular Exosome
	Molecular Function	Transporter Activity Protein Binding Calcium-dependent Phospholipid Binding	SNARE Binding Syntaxin-1 Binding Protein Kinase Binding Protein Domain Specific Binding Syntaxin Binding Identical Protein Binding Poly(A) RNA Binding Protein N-terminus Binding
	Biological Process	Synaptic Transmission Nervous System Development Synaptic Vesicle Exocytosis Regulation Of Calcium Ion-dependent Exocytosis	Platelet Degranulation Energy Reserve Metabolic Process Vesicle Docking Involved In Exocytosis Synaptic Transmission Neurotransmitter Secretion Neuromuscular Synaptic Transmission Axon Target Recognition Regulation Of Synaptic Vesicle Priming Glutamate Secretion Protein Transport Synaptic Vesicle Maturation Regulation Of Synaptic Vesicle Fusion To Presynaptic Membrane Negative Regulation Of Synaptic Transmission, GABAergic Regulation Of SNARE Complex Assembly Negative Regulation Of Neuron Apoptotic Process Small Molecule Metabolic Process Positive Regulation Of Calcium Ion-dependent Exocytosis Regulation Of Insulin Secretion Protein Stabilization Long Term Synaptic Depression Platelet Aggregation Protein Localization To Plasma Membrane
Pathways			Integration of energy metabolism Regulation of insulin secretion
Drugs
Diseases
GWAS
Protein-Protein Interactions		5 interactors: DYNLT1 RAP1GDS1 STXBP1 UBASH3B UNC13B	27 interactors: APBA1 APBA2 APP CDK5 CDK5R1 DOC2A DOC2B DYT10 HGS MAPT NEFH NEFM PLD1 PLD2 PRKCA PRKCB PRKCG SQSTM1 STX11 STX19 STX1A STX1B STX2 STX3 SYTL4 TRIM38 USO1
Entrez ID		8448	6812
HPRD ID		05195	04235
Ensembl ID		ENSG00000149927	ENSG00000136854
Uniprot IDs		Q14183	B7Z1V5 P61764 Q68CM6
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Synaptic Vesicle Priming Glutamate Secretion Regulation Of Synaptic Vesicle Exocytosis Establishment Of Organelle Localization Regulation Of Synaptic Vesicle Transport Organelle Localization Acid Secretion Positive Regulation Of Exocytosis Vesicle Docking Involved In Exocytosis Regulation Of Neurotransmitter Secretion Vesicle Docking Dicarboxylic Acid Transport Membrane Docking Neurotransmitter Secretion Positive Regulation Of Synaptic Vesicle Priming Microtubule-dependent Intracellular Transport Of Viral Material Towards Nucleus Synaptic Vesicle Transport Regulation Of Neurotransmitter Levels Positive Regulation Of Synaptic Vesicle Exocytosis Regulation Of Exocytosis Amino Acid Transport Regulation Of Synaptic Plasticity Neurotransmitter Transport Establishment Of Vesicle Localization Regulation Of Cellular Localization Vesicle Localization Regulation Of Synaptic Vesicle Fusion To Presynaptic Membrane Axon Target Recognition Positive Regulation Of Inhibitory Postsynaptic Membrane Potential Intracellular Transport Of Viral Protein In Host Cell Myosin Filament Assembly Regulation Of Signaling Regulation Of Rho GTPase Activity Negative Regulation Of Synaptic Transmission, GABAergic Regulation Of SNARE Complex Assembly Carboxylic Acid Transport Regulation Of Synaptic Transmission Organic Acid Transport Synaptic Vesicle Docking Positive Regulation Of Secretion Synaptic Vesicle Priming Regulation Of Protein Complex Assembly Regulation Of Rho Protein Signal Transduction Exocytosis Cellular Protein Complex Assembly Positive Regulation Of Mitochondrial Calcium Ion Concentration Negative Regulation Of Endoplasmic Reticulum Calcium Ion Concentration Negative Regulation Of Platelet Aggregation Regulation Of Vesicle-mediated Transport Regulation Of Short-term Neuronal Synaptic Plasticity	Synaptic Transmission Synaptic Vesicle Exocytosis Synaptic Vesicle Fusion To Presynaptic Membrane Neurotransmitter Secretion Synaptic Vesicle Transport Cell-cell Signaling Regulation Of Neurotransmitter Levels Establishment Of Localization In Cell Secretion By Cell Neurotransmitter Transport Vesicle Fusion Establishment Of Vesicle Localization Vesicle Localization Secretion Establishment Of Organelle Localization Cellular Localization Exocytosis Organelle Fusion Vesicle Docking Intracellular Transport Membrane Docking Organelle Localization Membrane Fusion Protein Localization Regulation Of Exocytosis Regulation Of Cellular Localization Protein Transport Membrane Organization Establishment Of Protein Localization Intracellular Protein Transport Signaling Transport Cell Communication Vesicle Organization Positive Regulation Of Exocytosis Vesicle-mediated Transport Cellular Protein Localization Regulation Of Vesicle-mediated Transport Peptidyl-threonine Phosphorylation Regulation Of Secretion Axon Cargo Transport Regulation Of Signaling Organelle Organization Positive Regulation Of Secretion Histone H3-T6 Phosphorylation Neurofilament Bundle Assembly Positive Regulation Of Transport Serine Phosphorylation Of STAT3 Protein Nervous System Development Regulation Of Synaptic Vesicle Transport
Tagcloud ?			16p12 2q24 5q14 9q34 aetiology caln1 cdkl5 cgh cnv cnvs counselling ehmt1 encephalopathies encompassing epileptic etiological grin2a hypsarrhythmia infantile intronic iss kcnq2 magi2 mef2c microdeletions microduplications scn2a spasms xq28
Tagcloud (Difference) ?			16p12 2q24 5q14 9q34 aetiology caln1 cdkl5 cgh cnv cnvs counselling ehmt1 encephalopathies encompassing epileptic etiological grin2a hypsarrhythmia infantile intronic iss kcnq2 magi2 mef2c microdeletions microduplications scn2a spasms xq28
Tagcloud (Intersection) ?