DOC2A and RAP1GDS1

Number of citations of the paper that reports this interaction (PubMedID 24722188)
69

Data Source:
BioGRID (two hybrid)

		DOC2A	RAP1GDS1
Description		double C2 domain alpha	Rap1 GTPase-GDP dissociation stimulator 1
Image
GO Annotations	Cellular Component	Lysosome Membrane Synaptic Vesicle Membrane Cytoplasmic Vesicle Neuron Projection Synapse Extrinsic Component Of Synaptic Vesicle Membrane Glutamatergic Synapse	Extracellular Space Nucleus Cytoplasm Mitochondrion Endoplasmic Reticulum Cytosol Extracellular Exosome
	Molecular Function	Protein Binding Calcium-dependent Phospholipid Binding Metal Ion Binding	Guanyl-nucleotide Exchange Factor Activity Protein Binding GTPase Regulator Activity
	Biological Process	Exocytosis Chemical Synaptic Transmission Nervous System Development Synaptic Vesicle Exocytosis Regulation Of Calcium Ion-dependent Exocytosis Positive Regulation Of Calcium Ion-dependent Exocytosis Spontaneous Neurotransmitter Secretion Calcium-dependent Activation Of Synaptic Vesicle Fusion	Cardiac Muscle Hypertrophy Regulation Of Mitochondrion Organization Vascular Associated Smooth Muscle Contraction Myosin Filament Assembly Negative Regulation Of Endoplasmic Reticulum Calcium Ion Concentration Protein Localization To Nucleus Positive Regulation Of Mitochondrial Calcium Ion Concentration Regulation Of ERK5 Cascade CAAX-box Protein Maturation Angiotensin-activated Signaling Pathway Involved In Heart Process Regulation Of Matrix Metallopeptidase Secretion
Pathways			RHOT2 GTPase cycle RHOT1 GTPase cycle
Drugs
Diseases
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) Body fat distribution (arm fat ratio) ( 30664634) Brain morphology (MOSTest) ( 32665545) Chronic obstructive pulmonary disease or high blood pressure (pleiotropy) ( 30940143) Height ( 28552196) Schizophrenia ( 25056061 28991256 29483656)	Biochemical measures ( 19260141) Response to fenofibrate (total cholesterol levels) ( 27002377) Suicidality in mood disorders ( 33783297) Suicide attempt severity in mood disorders ( 33783297)
Interacting Genes		6 interacting genes: DYNLT1 FOXP1 RAP1GDS1 STXBP1 UBASH3B UNC13B	23 interacting genes: AKT1 CDC42 DIRAS1 DOC2A EGFR HRAS KIFAP3 KRAS LCOR MBIP NRAS OGT PLEKHB1 PTPRF PUF60 RAC1 RAP1A RAP2B RHOA RNF19B RRAS2 UBC ZNF451
Entrez ID		8448	5910
HPRD ID		05195	11763
Ensembl ID		ENSG00000149927	ENSG00000138698
Uniprot IDs		Q14183	B3KNU0 P52306 Q6U7G8
PDB IDs		4MJJ	5XGC 5ZHX
Enriched GO Terms of Interacting Partners?		Dense Core Granule Exocytosis Neuronal Dense Core Vesicle Exocytosis Regulation Of Synaptic Vesicle Priming Syntaxin-1 Binding Synaptic Vesicle Priming Negative Regulation Of Cell Differentiation Secretory Granule Localization Nuclear Androgen Receptor Binding Calcium-ion Regulated Exocytosis Negative Regulation Of Developmental Process Vesicle Docking Involved In Exocytosis Regulation Of Cell Communication Regulation Of Signaling CAAX-box Protein Maturation Platelet Aggregation Positive Regulation Of Vesicle Docking Transport Of Viral Material Towards Nucleus Microtubule-dependent Intracellular Transport Of Viral Material Towards Nucleus Positive Regulation Of Synaptic Vesicle Priming Establishment Of Organelle Localization Negative Regulation Of Cell Development Vesicle Docking Homotypic Cell-cell Adhesion Regulation Of ERK5 Cascade Angiotensin-activated Signaling Pathway Involved In Heart Process Organelle Localization By Membrane Tethering Intracellular Transport Of Viral Protein In Host Cell Dense Core Granule Priming Positive Regulation Of Interleukin-21 Production Membrane Docking Regulation Of Signal Transduction Axon Target Recognition Regulation Of Acrosomal Vesicle Exocytosis Regulation Of Cell Development Negative Regulation Of Neuron Maturation Basal Dendrite Morphogenesis Basal Dendrite Arborization Regulated Exocytosis Establishment Of Vesicle Localization Myosin Filament Assembly Extrinsic Component Of Presynaptic Membrane Presynaptic Dense Core Vesicle Exocytosis Positive Regulation Of Glutamate Secretion, Neurotransmission Negative Regulation Of Synaptic Transmission, GABAergic Regulation Of Cell Differentiation [heparan Sulfate]-glucosamine 3-sulfotransferase Activity Regulation Of Transport Platelet Degranulation Vesicle Localization Regulation Of Glutamate Secretion, Neurotransmission	G Protein Activity GTPase Activity GDP Binding GTP Binding Small GTPase-mediated Signal Transduction Intracellular Signaling Cassette Glutamatergic Synapse Regulation Of Protein Localization To Membrane Nucleotide Binding Positive Regulation Of Intracellular Signal Transduction Regulation Of Phosphorus Metabolic Process Positive Regulation Of Protein Phosphorylation Regulation Of Cell Migration Regulation Of Protein Phosphorylation Positive Regulation Of Cell Migration Regulation Of Cell Motility Positive Regulation Of Signal Transduction Positive Regulation Of Phosphorylation Positive Regulation Of Cell Motility Endoplasmic Reticulum Membrane Regulation Of Locomotion Positive Regulation Of Locomotion Regulation Of Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Regulation Of Phosphorylation Regulation Of Protein Localization To Cell Periphery Regulation Of Protein Modification Process Intracellular Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Ras Protein Signal Transduction Positive Regulation Of Phosphate Metabolic Process Regulation Of Protein Localization To Synapse Regulation Of Receptor Localization To Synapse Positive Regulation Of Epithelial Cell Proliferation Cerebral Cortex Cell Migration Wnt Signaling Pathway, Planar Cell Polarity Pathway Positive Regulation Of Protein Modification Process Regulation Of Developmental Process Postsynapse Signal Transduction Positive Regulation Of Plasma Membrane Bounded Cell Projection Assembly Forebrain Radial Glial Cell Differentiation Cell Development Telencephalon Cell Migration Focal Adhesion Regulation Of Plasma Membrane Bounded Cell Projection Organization Apoptotic Process Positive Regulation Of Cell Cycle Process Cell Migration Forebrain Cell Migration
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