DOC2A and UNC13B

Number of citations of the paper that reports this interaction (PubMedID 9736751)
24

Data Source:
HPRD (in vitro, two hybrid)

		DOC2A	UNC13B
Description		double C2 domain alpha	unc-13 homolog B
Image			No pdb structure
GO Annotations	Cellular Component	Lysosome Membrane Synaptic Vesicle Membrane Cytoplasmic Vesicle Neuron Projection Synapse Extrinsic Component Of Synaptic Vesicle Membrane Glutamatergic Synapse	Cytoplasm Golgi Apparatus Cytosol Plasma Membrane Membrane Synaptic Vesicle Membrane Neuromuscular Junction Presynaptic Membrane Terminal Bouton Synapse Presynaptic Active Zone
	Molecular Function	Protein Binding Calcium-dependent Phospholipid Binding Metal Ion Binding	Calcium Ion Binding Protein Binding Calmodulin Binding Phospholipid Binding Zinc Ion Binding Syntaxin-1 Binding Diacylglycerol Binding GTP-dependent Protein Binding Small GTPase Binding Metal Ion Binding
	Biological Process	Exocytosis Chemical Synaptic Transmission Nervous System Development Synaptic Vesicle Exocytosis Regulation Of Calcium Ion-dependent Exocytosis Positive Regulation Of Calcium Ion-dependent Exocytosis Spontaneous Neurotransmitter Secretion Calcium-dependent Activation Of Synaptic Vesicle Fusion	Exocytosis Chemical Synaptic Transmission Positive Regulation Of Synaptic Vesicle Priming Synaptic Vesicle Docking Synaptic Vesicle Priming Synaptic Transmission, Glutamatergic Positive Regulation Of Apoptotic Process Positive Regulation Of Protein Secretion Acrosomal Vesicle Exocytosis Dense Core Granule Priming Cellular Response To Glucose Stimulus Positive Regulation Of Inhibitory Postsynaptic Potential Neuronal Dense Core Vesicle Exocytosis
Pathways			Serotonin Neurotransmitter Release Cycle Norepinephrine Neurotransmitter Release Cycle Glutamate Neurotransmitter Release Cycle Dopamine Neurotransmitter Release Cycle Acetylcholine Neurotransmitter Release Cycle
Drugs
Diseases
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) Body fat distribution (arm fat ratio) ( 30664634) Brain morphology (MOSTest) ( 32665545) Chronic obstructive pulmonary disease or high blood pressure (pleiotropy) ( 30940143) Height ( 28552196) Schizophrenia ( 25056061 28991256 29483656)	Parkinson's disease ( 21812969)
Interacting Genes		6 interacting genes: DYNLT1 FOXP1 RAP1GDS1 STXBP1 UBASH3B UNC13B	12 interacting genes: CFAP298 CLK1 DOC2A DOC2B PDCL2 RIMS1 RPH3AL SPTBN2 STX1A STX1B STX2 TOE1
Entrez ID		8448	10497
HPRD ID		05195	05785
Ensembl ID		ENSG00000149927	ENSG00000198722
Uniprot IDs		Q14183	A0A1B0GUS7 A0A1B0GVW8 O14795
PDB IDs		4MJJ
Enriched GO Terms of Interacting Partners?		Dense Core Granule Exocytosis Neuronal Dense Core Vesicle Exocytosis Regulation Of Synaptic Vesicle Priming Syntaxin-1 Binding Synaptic Vesicle Priming Negative Regulation Of Cell Differentiation Secretory Granule Localization Nuclear Androgen Receptor Binding Calcium-ion Regulated Exocytosis Negative Regulation Of Developmental Process Vesicle Docking Involved In Exocytosis Regulation Of Cell Communication Regulation Of Signaling CAAX-box Protein Maturation Platelet Aggregation Positive Regulation Of Vesicle Docking Transport Of Viral Material Towards Nucleus Microtubule-dependent Intracellular Transport Of Viral Material Towards Nucleus Positive Regulation Of Synaptic Vesicle Priming Establishment Of Organelle Localization Negative Regulation Of Cell Development Vesicle Docking Homotypic Cell-cell Adhesion Regulation Of ERK5 Cascade Angiotensin-activated Signaling Pathway Involved In Heart Process Organelle Localization By Membrane Tethering Intracellular Transport Of Viral Protein In Host Cell Dense Core Granule Priming Positive Regulation Of Interleukin-21 Production Membrane Docking Regulation Of Signal Transduction Axon Target Recognition Regulation Of Acrosomal Vesicle Exocytosis Regulation Of Cell Development Negative Regulation Of Neuron Maturation Basal Dendrite Morphogenesis Basal Dendrite Arborization Regulated Exocytosis Establishment Of Vesicle Localization Myosin Filament Assembly Extrinsic Component Of Presynaptic Membrane Presynaptic Dense Core Vesicle Exocytosis Positive Regulation Of Glutamate Secretion, Neurotransmission Negative Regulation Of Synaptic Transmission, GABAergic Regulation Of Cell Differentiation [heparan Sulfate]-glucosamine 3-sulfotransferase Activity Regulation Of Transport Platelet Degranulation Vesicle Localization Regulation Of Glutamate Secretion, Neurotransmission	Exocytosis Synaptic Vesicle Exocytosis Positive Regulation Of Calcium Ion-dependent Exocytosis Secretion By Cell Vesicle-mediated Transport In Synapse Calcium-ion Regulated Exocytosis Neurotransmitter Transport Regulated Exocytosis Spontaneous Neurotransmitter Secretion Regulation Of Calcium Ion-dependent Exocytosis Secretion Regulation Of Regulated Secretory Pathway SNARE Complex Positive Regulation Of Regulated Secretory Pathway Synaptic Vesicle Docking Signal Release Vesicle Docking Calcium-dependent Activation Of Synaptic Vesicle Fusion Regulation Of Exocytosis Vesicle-mediated Transport Organelle Localization By Membrane Tethering Positive Regulation Of Exocytosis Positive Regulation Of Vesicle Fusion Membrane Docking Regulation Of Synaptic Vesicle Fusion To Presynaptic Active Zone Membrane Regulation Of Vesicle-mediated Transport Presynaptic Active Zone Membrane Regulation Of Secretion By Cell Positive Regulation Of Secretion By Cell Positive Regulation Of Excitatory Postsynaptic Potential Positive Regulation Of Secretion Regulation Of Secretion Regulation Of Vesicle Fusion SNAP Receptor Activity Vesicle Docking Involved In Exocytosis Neurotransmitter Secretion Membrane Fusion Modulation Of Excitatory Postsynaptic Potential SNARE Binding Presynapse Calcium Ion-regulated Exocytosis Of Neurotransmitter Intracellular Protein Transport Synaptic Vesicle Fusion To Presynaptic Active Zone Membrane Vesicle Fusion To Plasma Membrane Establishment Of Localization In Cell Regulation Of Synaptic Vesicle Priming Regulation Of Neurotransmitter Secretion Vesicle Fusion Organelle Membrane Fusion Synaptic Vesicle Membrane Organization
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