CUL7 and PLXNB3

Number of citations of the paper that reports this interaction (PMID 12421765)
28

Data Source:
HPRD (two hybrid)

		CUL7	PLXNB3
Gene Name		cullin 7	plexin B3
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Anaphase-promoting Complex Cytoplasm Golgi Apparatus Centrosome Cytosol Cul7-RING Ubiquitin Ligase Complex Perinuclear Region Of Cytoplasm 3M Complex	Intracellular Plasma Membrane Integral Component Of Membrane
	Molecular Function	Protein Binding Ubiquitin Protein Ligase Binding	Protein Binding Semaphorin Receptor Activity Protein Domain Specific Binding Rho GDP-dissociation Inhibitor Binding
	Biological Process	Microtubule Cytoskeleton Organization Mitotic Cytokinesis Vasculogenesis Epithelial To Mesenchymal Transition Placenta Development Proteolysis Ubiquitin-dependent Protein Catabolic Process Activation Of Signaling Protein Activity Involved In Unfolded Protein Response Golgi Organization Regulation Of Mitotic Nuclear Division Viral Process Protein Ubiquitination Endoplasmic Reticulum Unfolded Protein Response Cellular Protein Metabolic Process Positive Regulation Of Dendrite Morphogenesis	Positive Regulation Of Endothelial Cell Proliferation Negative Regulation Of Cell Adhesion Axon Guidance Negative Regulation Of Lamellipodium Assembly Negative Regulation Of Cell Migration Negative Regulation Of GTPase Activity Positive Chemotaxis Cell Chemotaxis Semaphorin-plexin Signaling Pathway
Pathways		IRE1alpha activates chaperones Antigen processing: Ubiquitination & Proteasome degradation Class I MHC mediated antigen processing & presentation XBP1(S) activates chaperone genes Unfolded Protein Response (UPR) Adaptive Immune System	Axon guidance Semaphorin interactions Other semaphorin interactions
Drugs
Diseases
GWAS
Protein-Protein Interactions		7 interactors: COMMD1 FBXW8 MEGF10 PLXNB3 RBX1 SKP1 UBE2M	8 interactors: ARHGEF11 BTBD3 CUL7 CUL9 MAGI2 MAGI3 RIT2 SPOCK2
Entrez ID		9820	5365
HPRD ID		09901	02198
Ensembl ID		ENSG00000044090	ENSG00000198753
Uniprot IDs		Q14999	A8K920 B7Z3H9 Q9ULL4
PDB IDs		2JNG
Enriched GO Terms of Interacting Partners?		Protein Neddylation Protein Ubiquitination Protein Modification By Small Protein Conjugation SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein Monoubiquitination Skeletal Muscle Satellite Cell Proliferation Skeletal Muscle Cell Proliferation Skeletal Muscle Satellite Cell Activation Positive Regulation Of Protein Ubiquitination Notch Signaling Pathway Negative Regulation Of Lamellipodium Assembly Regulation Of Protein Ubiquitination Negative Regulation Of Sodium Ion Transmembrane Transport Skeletal Muscle Satellite Cell Differentiation Recognition Of Apoptotic Cell Plasma Membrane To Endosome Transport Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Negative Regulation Of Protein Localization To Cell Surface Histone H2A Monoubiquitination Negative Regulation Of Sodium Ion Transport Histone H2A Ubiquitination Phagocytosis, Recognition Regulation Of Protein Catabolic Process Spongiotrophoblast Layer Development	Neurotrophin Signaling Pathway Nervous System Development Cytokinesis Planar Cell Polarity Pathway Involved In Axis Elongation Regulation Of Mitotic Nuclear Division Cellular Response To Growth Factor Stimulus Response To Growth Factor Positive Regulation Of Catalytic Activity Generation Of Neurons Neurogenesis Cell Morphogenesis Involved In Differentiation Cell Development Cellular Response To Organic Substance Signal Transduction Neurotrophin TRK Receptor Signaling Pathway Regulation Of Cellular Component Organization Positive Regulation Of Neuron Projection Development Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Cell Cycle Regulation Of Cell Division Negative Regulation Of Activin Receptor Signaling Pathway Signaling Glomerular Visceral Epithelial Cell Development Cell Communication Positive Regulation Of Cell Projection Organization Positive Regulation Of Hydrolase Activity Cell Cycle Process Cell Morphogenesis Positive Regulation Of Phosphoprotein Phosphatase Activity Nerve Growth Factor Signaling Pathway Peptide Cross-linking Via Chondroitin 4-sulfate Glycosaminoglycan Cytoskeleton Organization Regulation Of Catalytic Activity Positive Regulation Of Neuron Differentiation Anatomical Structure Morphogenesis Mitotic Cell Cycle Arrest Glomerular Visceral Epithelial Cell Differentiation System Development Response To Organic Substance Positive Regulation Of Receptor Internalization Positive Regulation Of Cellular Metabolic Process Regulation Of Neuron Projection Development Wnt Signaling Pathway, Planar Cell Polarity Pathway Cellular Response To Stimulus Regulation Of Activin Receptor Signaling Pathway Regulation Of Mitotic Cell Cycle Positive Regulation Of Neurogenesis Cell Cycle Cell Division Microtubule Cytoskeleton Organization
Tagcloud ?		112g 11p15 1291delt 45m 6psi ccdc8 encompasses genetics ghi ghr height homozygous hypomethylation igf1 igfals imprinting insensitive insensitivity ivs5ds justifying mupd7 obsl1 pseudoexon russell sds srs stat5b stature suspected	alias amplifications bgn casp9 ccnc cgh e2f5 eck efnb3 epha2 ercc1 fgf3 fgr frap1 hspg2 il12a l1cam lamc1 mexican nonaffected outline pctk2 pctk3 plexr tnfrsf10a tnfrsf10b tp73 turned underexpressed
Tagcloud (Difference) ?		112g 11p15 1291delt 45m 6psi ccdc8 encompasses genetics ghi ghr height homozygous hypomethylation igf1 igfals imprinting insensitive insensitivity ivs5ds justifying mupd7 obsl1 pseudoexon russell sds srs stat5b stature suspected	alias amplifications bgn casp9 ccnc cgh e2f5 eck efnb3 epha2 ercc1 fgf3 fgr frap1 hspg2 il12a l1cam lamc1 mexican nonaffected outline pctk2 pctk3 plexr tnfrsf10a tnfrsf10b tp73 turned underexpressed
Tagcloud (Intersection) ?