CUL7

Description		cullin 7
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GO Annotations	Cellular Component	Anaphase-promoting Complex Cytoplasm Golgi Apparatus Centrosome Cytosol Cytoskeleton Cullin-RING Ubiquitin Ligase Complex Cul7-RING Ubiquitin Ligase Complex Perinuclear Region Of Cytoplasm 3M Complex
	Molecular Function	Protein Binding Ubiquitin Protein Ligase Binding Ubiquitin Ligase Complex Scaffold Activity
	Biological Process	Microtubule Cytoskeleton Organization Mitotic Cytokinesis Vasculogenesis Epithelial To Mesenchymal Transition Placenta Development Proteolysis Ubiquitin-dependent Protein Catabolic Process Golgi Organization Regulation Of Mitotic Nuclear Division Insulin Receptor Signaling Pathway Protein Ubiquitination Negative Regulation Of Insulin Receptor Signaling Pathway Positive Regulation Of Dendrite Morphogenesis
Pathways		XBP1(S) activates chaperone genes Neddylation Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases		3M syndrome
GWAS		Appendicular lean mass ( 33097823)
Interacting Genes		10 interacting genes: COMMD1 FBXW8 MEGF10 MTDH MTNR1A PLXNB3 RBX1 SKP1 TP53 UBE2M
Entrez ID		9820
HPRD ID		09901
Ensembl ID		ENSG00000044090
Uniprot IDs		A0A669KBH4 Q14999
PDB IDs		2JNG 7Z8B
Enriched GO Terms of Interacting Partners?		Cul7-RING Ubiquitin Ligase Complex Nucleotide-excision Repair NEDD8 Transferase Activity SCF Ubiquitin Ligase Complex Negative Regulation Of Mitophagy Regulation Of Proteolysis Cul2-RING Ubiquitin Ligase Complex Positive Regulation Of Epithelial Cell Apoptotic Process Negative Regulation Of Proteolysis Protein Neddylation Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Cullin Family Protein Binding Molecular Function Activator Activity Regulation Of Ubiquitin-dependent Protein Catabolic Process RNA Polymerase II-specific DNA-binding Transcription Factor Binding Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Macroautophagy Copper Ion Binding Regulation Of Mitophagy DNA Damage Response, Signal Transduction By P53 Class Mediator Negative Regulation Of Cellular Response To Insulin Stimulus Negative Regulation Of Insulin Receptor Signaling Pathway Regulation Of Autophagy Of Mitochondrion Regulation Of Epithelial Cell Apoptotic Process Protein Monoubiquitination Protein Modification By Small Protein Conjugation Mitophagy SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Helicase Activity Negative Regulation Of G1 To G0 Transition Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Cholesterol Import Interferon-mediated Signaling Pathway Regulation Of Insulin Receptor Signaling Pathway Autophagy Of Mitochondrion Regulation Of Neurogenesis Post-translational Protein Modification Apoptotic Process Oligodendrocyte Apoptotic Process Negative Regulation Of Pentose-phosphate Shunt Cellular Response To UV Negative Regulation Of Glucose Catabolic Process To Lactate Via Pyruvate Negative Regulation Of Catabolic Process Regulation Of Autophagy NEDD8 Conjugating Enzyme Activity Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Regulation Of Cellular Response To Insulin Stimulus Regulation Of Protein Catabolic Process Insulin Receptor Signaling Pathway
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