CDKL3 and RABEP1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		CDKL3	RABEP1
Description		cyclin dependent kinase like 3	rabaptin, RAB GTPase binding effector protein 1
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GO Annotations	Cellular Component	Nucleus Cytoplasm	Cytoplasm Endosome Early Endosome Cytosol Endocytic Vesicle Cytoplasmic Vesicle Early Endosome Membrane Protein-containing Complex Recycling Endosome Glutamatergic Synapse
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Cyclin-dependent Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Serine Kinase Activity	GTPase Activator Activity Protein Binding Growth Factor Activity Protein Domain Specific Binding Protein Homodimerization Activity
	Biological Process	Negative Regulation Of Axon Extension Protein Modification Process Positive Regulation Of Dendrite Morphogenesis Regulation Of Cell Cycle Dendrite Extension	Golgi To Plasma Membrane Transport Endocytosis Apoptotic Process Signal Transduction Protein Transport Vesicle-mediated Transport Membrane Fusion Regulation Of Postsynaptic Neurotransmitter Receptor Internalization Protein Localization To Ciliary Membrane
Pathways			TBC/RABGAPs
Drugs
Diseases
GWAS		Eosinophil count ( 27863252) Moderate-to-late spontaneous preterm birth ( 31194736)	Body mass index ( 25673413 28892062) Lymphocyte count ( 32888494) Mean platelet volume ( 32888494) Red blood cell density in sickle cell anemia ( 28552477) White blood cell count ( 27863252)
Interacting Genes		31 interacting genes: APP ATG4A CYSRT1 DISC1 DNAAF6 FXR1 FXR2 GGA1 GOLGA2 IKZF1 KANK2 KASH5 KRTAP10-9 LRP2BP LRRK2 LZTS2 MCC MDFI MTUS2 PICK1 PIH1D2 RABEP1 SNRNP70 SRPK1 TRIM27 TRIM37 TTF2 ZBTB14 ZBTB43 ZBTB8A ZRANB1	60 interacting genes: ABI2 AIMP2 AP1G1 AP1G2 ATXN7 BARD1 CASP3 CCDC120 CCND1 CDC73 CDK18 CDKL3 CEP57 CFAP53 ELOA ESCO2 FAM50B FAM90A1 GAP43 GGA1 GGA2 GGA3 HUNK ITSN1 LENG1 MAT2B MCRS1 NRIP1 ODAD3 PELI2 PKP2 PRPF3 RAB1A RAB33B RAB4A RAB4B RAB5A RABGEF1 RGS17 RNF39 SMURF1 SNAPIN SNCA SNW1 SRPK2 STAR TNS4 TRAPPC2L TRIM26 TSC2 TSHZ2 UBC UBTFL1 USP2 UTP14C WASHC3 YWHAG ZNF438 ZNF512B ZNF774
Entrez ID		51265	9135
HPRD ID		09766	04684
Ensembl ID		ENSG00000006837	ENSG00000029725
Uniprot IDs		B4DX41 Q8IVW4	B4DMM4 Q15276
PDB IDs		3ZDU	1P4U 1TU3 1X79 4N3Y 4N3Z 4Q9U
Enriched GO Terms of Interacting Partners?		Regulation Of Wnt Signaling Pathway Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Regulation Of Long-term Neuronal Synaptic Plasticity Negative Regulation Of Autophagy Positive Regulation Of Catabolic Process Protein Localization To Ciliary Membrane Cellular Response To Manganese Ion Positive Regulation Of Long-term Neuronal Synaptic Plasticity Wnt Signaling Pathway Regulation Of Neuronal Synaptic Plasticity Cellular Component Assembly Negative Regulation Of Long-term Synaptic Potentiation Identical Protein Binding Negative Regulation Of Wnt Signaling Pathway Modulation Of Chemical Synaptic Transmission Protein Homodimerization Activity Cellular Localization Response To Manganese Ion Neuron Projection Regulation Of Receptor Internalization Cytoplasm Regulation Of Synaptic Transmission, Glutamatergic Golgi-associated Vesicle Cellular Response To Catecholamine Stimulus Translation Regulator Activity Regulation Of Synaptic Plasticity Positive Regulation Of Protein Metabolic Process Response To Catecholamine Negative Regulation Of Catabolic Process Negative Regulation Of Metabolic Process Negative Regulation Of RNA Metabolic Process Postsynapse Presynapse Regulation Of Primary Metabolic Process Dentate Gyrus Development Regulation Of Canonical Wnt Signaling Pathway Intracellular Transport Positive Regulation Of Receptor Internalization Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Negative Regulation Of Transcription By RNA Polymerase II Amylin Binding Positive Regulation Of Toll Signaling Pathway Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Receptor-mediated Endocytosis Negative Regulation Of Macromolecule Metabolic Process Organelle Assembly Aggresome	Intracellular Protein Localization Vesicle-mediated Transport Golgi Vesicle Transport Protein Binding Early Endosome Membrane Protein Transport Establishment Of Protein Localization Endosome Intracellular Transport Regulation Of Vesicle-mediated Transport G Protein Activity Recycling Endosome Cellular Localization Establishment Of Localization In Cell Vesicle-mediated Transport In Synapse Intracellular Protein Transport Rab Protein Signal Transduction Post-Golgi Vesicle-mediated Transport Endosomal Transport Intracellular Vesicle Regulation Of Exocytosis Small GTPase Binding Positive Regulation Of Protein Metabolic Process Intracellular Signal Transduction GTPase Activity Early Endosome Post-translational Protein Modification Protein Localization To Cell Surface Presynapse Insulin-responsive Compartment Negative Regulation Of Exocytosis Golgi To Plasma Membrane Protein Transport Vacuolar Transport Synaptic Vesicle Endocytosis Cytoplasmic Vesicle Membrane Protein Localization To Organelle Nucleus Secretion Protein Modification Process Secretion By Cell Protein Polyubiquitination Presynaptic Endocytosis Regulation Of MRNA 3'-end Processing Endosome Membrane Protein Localization To Plasma Membrane Positive Regulation Of Translational Initiation Regulation Of Endosome Size Regulation Of Cellular Component Organization Exocytosis AP-1 Adaptor Complex
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