MON1A and RABGEF1

Number of citations of the paper that reports this interaction (PMID 20434987)
96

Data Source:
BioGRID (pull down)

		MON1A	RABGEF1
Gene Name		MON1 secretory trafficking family member A	RAB guanine nucleotide exchange factor (GEF) 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component		Early Endosome Vesicle Recycling Endosome
	Molecular Function		DNA Binding Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Rab Guanyl-nucleotide Exchange Factor Activity Rab GTPase Binding
	Biological Process		Negative Regulation Of Protein Phosphorylation Negative Regulation Of Leukocyte Migration Protein Targeting To Membrane Endocytosis Protein Ubiquitination Positive Regulation Of Rab GTPase Activity Negative Regulation Of Mast Cell Degranulation Negative Regulation Of Ras Protein Signal Transduction Negative Regulation Of Receptor-mediated Endocytosis Negative Regulation Of Inflammatory Response Regulation Of Fc Receptor Mediated Stimulatory Signaling Pathway Negative Regulation Of Interleukin-6 Secretion Negative Regulation Of Kit Signaling Pathway
Pathways
Drugs
Diseases
GWAS			Aortic root size ( 21223598)
Protein-Protein Interactions		6 interactors: GFI1B MAPK6 RABGEF1 RGS2 TAB1 VPS33A	30 interactors: AP1G1 BLOC1S6 CIPC DAZAP2 DGCR6 GGA1 GGA2 HRAS KXD1 L1CAM MON1A MON1B RAB21 RAB33B RAB4A RABEP1 RNF11 RNF168 RPS27A TEAD4 THOC1 TRIM15 TRIM54 TXN2 UBB UBC UBE2D1 UBE2D3 YWHAB ZC2HC1C
Entrez ID		84315	27342
HPRD ID		17586	11477
Ensembl ID		ENSG00000164077	ENSG00000243335
Uniprot IDs		Q86VX9	B4DZM7 Q9UJ41
PDB IDs			1TXU 2C7M 2C7N 2OT3
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Kit Signaling Pathway Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process Negative Regulation Of Interleukin-6 Secretion Negative Regulation Of Mast Cell Degranulation MAPK Cascade Negative Regulation Of Mast Cell Activation Involved In Immune Response Regulation Of Adrenergic Receptor Signaling Pathway Regulation Of Protein Phosphorylation Positive Regulation Of Cardiac Muscle Contraction Negative Regulation Of CAMP-mediated Signaling Negative Regulation Of Phospholipase Activity Signal Transduction By Phosphorylation Activation Of MAPKKK Activity Regulation Of Fc Receptor Mediated Stimulatory Signaling Pathway Regulation Of MAP Kinase Activity Relaxation Of Vascular Smooth Muscle Relaxation Of Smooth Muscle Negative Regulation Of Cardiac Muscle Hypertrophy Negative Regulation Of Protein Phosphorylation Negative Regulation Of Mast Cell Activation Positive Regulation Of Striated Muscle Contraction Negative Regulation Of Muscle Hypertrophy Regulation Of Phosphorylation Positive Regulation Of Microtubule Polymerization Relaxation Of Cardiac Muscle Negative Regulation Of Smooth Muscle Contraction Negative Regulation Of Phosphorylation Regulation Of Phosphorus Metabolic Process Negative Regulation Of Intracellular Signal Transduction Positive Regulation Of Catalytic Activity Negative Regulation Of Receptor-mediated Endocytosis Negative Regulation Of Lipase Activity Negative Regulation Of Leukocyte Migration Negative Regulation Of Muscle Contraction Platelet Formation Platelet Morphogenesis Regulation Of CAMP-mediated Signaling Relaxation Of Muscle Regulation Of Histone H3-K4 Methylation Regulation Of Developmental Pigmentation Regulation Of Mast Cell Degranulation Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Regulation Of Intracellular Signal Transduction Positive Regulation Of Heart Contraction Regulation Of Microtubule Polymerization Regulation Of Cardiac Muscle Hypertrophy Lysosome Localization Vasodilation Regulation Of Mast Cell Activation	Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Regulation Of DNA-templated Transcription In Response To Stress Regulation Of Immune System Process TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Regulation Of Immune Response Intracellular Transport Of Virus Toll-like Receptor 4 Signaling Pathway Response To Hypoxia Transcription Initiation From RNA Polymerase II Promoter Protein Polyubiquitination Intracellular Transport Positive Regulation Of Innate Immune Response Establishment Of Localization In Cell Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Regulation Of Type I Interferon Production Toll-like Receptor Signaling Pathway Cellular Response To Oxygen Levels Protein Transport Innate Immune Response DNA-templated Transcription, Initiation Cellular Response To Growth Factor Stimulus Negative Regulation Of Type I Interferon Production Viral Protein Processing Response To Growth Factor Establishment Of Protein Localization Regulation Of Innate Immune Response Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Positive Regulation Of Immune System Process Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Activation Of Innate Immune Response Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Immune Response-regulating Signaling Pathway Cellular Localization Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Negative Regulation Of Ubiquitin-protein Transferase Activity Immune Response Mitotic Cell Cycle Checkpoint Epidermal Growth Factor Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Ubiquitin-dependent Protein Catabolic Process Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Positive Regulation Of Ubiquitin-protein Transferase Activity
Tagcloud ?			abca7 adssl1 apoe bin1 cd2ap cd33 cognitively cr1 epha1 fbxl2 hallmark haplotype intron load map2k4 modifier ms4a4a ms4a6e multifactorial picalm plink pomt2 ppp2r5c sh3kbp1 snp snx8 synj1 xpo1 xrn1
Tagcloud (Difference) ?			abca7 adssl1 apoe bin1 cd2ap cd33 cognitively cr1 epha1 fbxl2 hallmark haplotype intron load map2k4 modifier ms4a4a ms4a6e multifactorial picalm plink pomt2 ppp2r5c sh3kbp1 snp snx8 synj1 xpo1 xrn1
Tagcloud (Intersection) ?